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  1. Rosilawati, R., Lee, H.L., Nazni, W.A., Nurulhusna, A.H., Roziah, A., Khairul Asuad, M., et al.
    MyJurnal
    Vector control is still the principal method to control dengue and chemical insecticides, especially the
    pyrethroids such as permethrin are the forerunners of mosquito control agent. Intensive and extensive use
    of pyrethroids often result in resistance, thereby hampering control efforts. The present study was
    conducted to evaluate the susceptible status of Aedes aegypti, the primary vector of dengue against
    permethrin. A nationwide mosquito sampling via ovitrapping was conducted in 12 dengue hotspots across 5
    states in Peninsular Malaysia. Field collected Aedes eggs were hatched and reared until L3 larval and further
    identified it species. Adult F0 Aedes aegypti were reared until F1 progeny and the female were used in
    adult assay, performed according to World Health Organization (WHO) protocol as to determine the
    resistance level. The laboratory strain maintained for more than 1000 generations that were susceptible to
    permethrin served as the control strain. Evaluation of resistance ratio was assessed by comparing the
    knockdown rate with laboratory susceptible strain. In this present study, 70% ofAe. aegypti population from
    dengue hotspots was highly resistance to permethrin. The study clearly demonstrated that widespread of
    permethrin resistant Ae. aegypti in Malaysian mosquito’s population, indicating the need of implementing
    an efficient pyrethroid resistance management.
  2. Noor Afizah A, Roziah A, Nazni WA, Lee HL
    Indian J Med Res, 2015 Aug;142(2):205-10.
    PMID: 26354218 DOI: 10.4103/0971-5916.164259
    Wolbachia-based vector control strategies have been proposed as a mean to augment the existing measures for controlling dengue vector. Prior to utilizing Wolbachia in novel vector control strategies, it is crucial to understand the Wolbachia-mosquito interactions. Many studies have only focused on the prevalence of Wolbachia in female Aedes albopictus with lack of attention on Wolbachia infection on the male Ae. albopictus which also affects the effective expression of Wolbachia induced- cytoplasmic incompatibility (CI). In this study, field surveys were conducted to screen for the infection status of Wolbachia in female and male Ae. albopictus from various habitats including housing areas, islands and seashore.
  3. Lee HL, Rohani A, Khadri MS, Nazni WA, Rozilawati HA, Nurulhusna AH, et al.
    MyJurnal
    Dengue is a serious mosquito borne disease common in tropical and sub-tropical countries including Malaysia. There is at present a lack of specific treatment and an effective tetravalent vaccine against dengue. The control of dengue depends solely on the suppression of the two most important vectors namely, Aedes aegypti and Ae albopictus. Despite intensive and extensive control efforts by health agencies, the disease continues to spread. This paper updates various innovations on control of dengue vectors. Gene-based sterile insect technique using the RIDL technology for both Aedes aegypti & Ae albopictus control has now been actively researched and field trials are pursued to evaluate the effectiveness of the technology. The release of Wolbachia-infected Ae aegypti is another dengue control innovation. The infected mosquito cannot support development of dengue virus and has shorter life span. Other innovations include: auto-dissemination of insect control agents using ovitrap, autocidal adult and larva trap, outdoor residual spraying, insecticidal paint and biocontrol agent. In other innovation, outbreak prediction capability is enhanced by developing model based on environmental data and analysis utilising neural network.
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