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  1. Alenezi SA, Dannoon SF, Alnafisi NS, Asa'ad SM, Osman MM, Elgazzar AH
    World J Nucl Med, 2020 01 14;19(1):41-46.
    PMID: 32190021 DOI: 10.4103/wjnm.WJNM_16_19
    The aim of this study is to investigate the relationship between brown adipose tissue (BAT) activation and myocardial fluorine-18-fluorodeoxyglucose ([18F] FDG) uptake in terms of intensity and patterns. The patients were divided into two groups as follows: BAT and control groups. The BAT group consists of 34 cases that showed BAT uptake. The control group, with no BAT uptake, included 68 patients who were matched for body mass index, gender, and season. The scans were retrospectively reviewed by two nuclear medicine physicians who visually evaluated the intensity of myocardial [18F] FDG uptake. The myocardial [18F] FDG uptake was visually classified into the following three patterns: diffuse, heterogeneous, and focal. The regions of activated BAT distribution were noted. The mean myocardial [18F] FDG uptake was 2.50 ± 0.75 for the BAT group and 2.13 ± 0.88 for the control group with a statistically significant difference (P = 0.031). The myocardial [18F] FDG uptake pattern was similar in the BAT and control groups with the diffuse pattern being the most common, followed by the heterogeneous and less commonly focal. In the BAT group, the anatomical distribution of BAT was mainly in supraclavicular, paravertebral, and axillary and to a lesser extent in cervical regions. BAT group had a significantly higher intensity of [18F] FDG myocardial uptake compared to that of the control group. The presence of activated BAT did not affect the pattern of myocardial uptake. Knowledge of these findings may help in understanding the variability of myocardial [18F] FDG uptake and consequently in avoiding misinterpretation of cardiac findings in positron-emission tomography/computed tomography studies.
  2. Varghese E, Samson RS, Albaker SA, Thomas AA, Alqarni AS, Dhanya KB
    J Pharm Bioallied Sci, 2023 Jul;15(Suppl 1):S451-S454.
    PMID: 37654276 DOI: 10.4103/jpbs.jpbs_584_22
    AIM: The present research was conducted to assess the microleakage of stainless steel crowns along with pedo jacket crowns following cementation with different luting cements.

    MATERIALS AND METHODS: A total of 60 deciduous teeth subjected to extraction were employed in this in vitro research. These 60 specimens were randomly divided into two groups: Group I: Stainless steel crowns and Group II: Pedo Jacket crowns. Both crowns were subjected to cementation using self-cure resin-modified glass ionomer (RMGI) cement as well as by means of self-adhesive universal resin cement (RelyX luting cement). The specimens were subjected to storage in distilled water at 37°C for 24 h and were subjected to 500 thermal cycles between 5°C and 55°C using a dwell span of 30 s. Individual surfaces were assessed for the amount of dye infiltration at the boundaries by the side of the tooth-cement border beneath a stereomicroscope under 50× magnifying power. At the mesial and distal surfaces, the amount of microleakage was measured in micrometers (μm), and the mean value was computed for each sample.

    RESULTS: Stainless steel crowns subject to cementation with RelyX luting cement exhibited the lowest microleakage (0.88 ± 0.78) versus self-cure RMGI cement (0.94 ± 0.78). There was no statistically significant difference found between the groups. Pedo Jacket crowns subject to cementation with RelyX luting cement exhibited the lowest microleakage (0.96. ± 0.32) while self-cure RMGI cement (1.83 ± 0.16) depicted the maximum microleakage. There was an extremely statistically noteworthy dissimilarity noted among the groups.

    CONCLUSION: The current research concluded that Pedo Jacket crowns subjected to cementation with RelyX luting cement can be regarded as an esthetically pleasing restorative alternative for numerous young patients. Applying RelyX luting cement to Pedo Jacket crowns provides a strong bolstering by composite materials that ensures the success of the therapy provided.

  3. Akram Z, Al-Shareef SA, Daood U, Asiri FY, Shah AH, AlQahtani MA, et al.
    Photomed Laser Surg, 2016 Apr;34(4):137-49.
    PMID: 26982216 DOI: 10.1089/pho.2015.4076
    The aim of this study was to assess the bactericidal efficacy of antimicrobial photodynamic dynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) against periodontal pathogens.
  4. Rubnawaz S, Kayani WK, Akhtar N, Mahmood R, Khan A, Okla MK, et al.
    Molecules, 2021 Aug 11;26(16).
    PMID: 34443462 DOI: 10.3390/molecules26164874
    Ajuga bracteosa Wall. ex Benth. is an endangered medicinal herb traditionally used against different ailments. The present study aimed to create new insight into the fundamental mechanisms of genetic transformation and the biological activities of this plant. We transformed the A. bracteosa plant with rol genes of Agrobacterium rhizogenes and raised the regenerants from the hairy roots. These transgenic regenerants were screened for in vitro antioxidant activities, a range of in vivo assays, elemental analysis, polyphenol content, and different phytochemicals found through HPLC. Among 18 polyphenolic standards, kaempferol was most abundant in all transgenic lines. Furthermore, transgenic line 3 (ABRL3) showed maximum phenolics and flavonoids content among all tested plant extracts. ABRL3 also demonstrated the highest total antioxidant capacity (8.16 ± 1 μg AAE/mg), total reducing power, (6.60 ± 1.17 μg AAE/mg), DPPH activity (IC50 = 59.5 ± 0.8 μg/mL), hydroxyl ion scavenging (IC50 = 122.5 ± 0.90 μg/mL), and iron-chelating power (IC50 = 154.8 ± 2 μg/mL). Moreover, transformed plant extracts produced significant analgesic, anti-inflammatory, anticoagulant, and antidepressant activities in BALB/c mice models. In conclusion, transgenic regenerants of A. bracteosa pose better antioxidant and pharmacological properties under the effect of rol genes as compared to wild-type plants.
  5. Saleem H, Goh PS, Saud A, Khan MAW, Munira N, Ismail AF, et al.
    Nanomaterials (Basel), 2022 Nov 24;12(23).
    PMID: 36500777 DOI: 10.3390/nano12234154
    Forward osmosis (FO) technology for desalination has been extensively studied due to its immense benefits over conventionally used reverse osmosis. However, there are some challenges in this process such as a high reverse solute flux (RSF), low water flux, and poor chlorine resistance that must be properly addressed. These challenges in the FO process can be resolved through proper membrane design. This study describes the fabrication of thin-film composite (TFC) membranes with polyethersulfone solution blown-spun (SBS) nanofiber support and an incorporated selective layer of graphene quantum dots (GQDs). This is the first study to sustainably develop GQDs from banyan tree leaves for water treatment and to examine the chlorine resistance of a TFC FO membrane with SBS nanofiber support. Successful GQD formation was confirmed with different characterizations. The performance of the GQD-TFC-FO membrane was studied in terms of flux, long-term stability, and chlorine resistance. It was observed that the membrane with 0.05 wt.% of B-GQDs exhibited increased surface smoothness, hydrophilicity, water flux, salt rejection, and chlorine resistance, along with a low RSF and reduced solute flux compared with that of neat TFC membranes. The improvement can be attributed to the presence of GQDs in the polyamide layer and the utilization of SBS nanofibrous support in the TFC membrane. A simulation study was also carried out to validate the experimental data. The developed membrane has great potential in desalination and water treatment applications.
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