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  1. Fulltext Innovations in flapless corticotomy to accelerate orthodontic tooth movement: a review focusing on the different techniques, limitations and future possibilities
    Sharmin Sultana, Norma Ab Rahman, Siti Lailatul Akmar Zainuddin, Basaruddin Ahmad
    Malaysian Journal of Medicine and Health Sciences, 2020;16(2):308-315.
    MyJurnal
    The aim of this narrative review is to discuss on different approaches of the flapless corticotomy techniques to ac- celerate orthodontic tooth movement. There was limited understanding about the effect of the surgical procedures because of the great variations in the procedures between the flapless corticotomy techniques. Hence, no specific technique can be claimed to be superior to another. Eleven clinical trials have been reviewed from PubMed, Science Direct, and Google Scholar using the keywords such as accelerated, orthodontic tooth movement (OTM), minimally invasive corticotomy, RAP, corticision, piezocision, lasercision/laser assisted flapless corticotomy (LAFC), micro-os- teoperforations (MOPs), discision and their combinations in the last 10 years. Early reports showed that Piezocision, MOPs and LAFC procedures are comparatively less aggressive flapless corticotomy procedure to accelerate OTM and more comfortable to the patient.
  2. The Effect of Tualang Honey on Human Periodontal Ligament Fibroblast Proliferation and Alkaline Phosphatase Level
    Haslina Taib, Lau Xin Yu, Zurairah Berahim, Azlina Ahmad, Siti Lailatul Akmar Zainuddin
    Sains Malaysiana, 2015;44:1021-1025.
    Previous studies on honey have shown its potential as an alternative approach in optimizing medical resources for periodontal treatment. However, to date, there has been no study published on the effects of honey on human periodontal ligament fibroblasts (HPDLFs). The aimed of this study was to investigate the effect of Tualang honey on HPDLF proliferation and alkaline phosphatase (ALP) level with an intention to establish honey as one of the natural products which may promote healing and regeneration of periodontium. The HPDLFs were cultured and treated with honey at four different concentrations (0.02, 0.3, 1 and 5%) in a 96-well plate and incubated at 37°C with 5% CO2. Proliferation test (MTT test) was assessed up to day 3 whereas ALP level (ALP assay) was assessed up to day 7. The αMEM supplemented with 10% FBS and 1% penicillin streptomycin was used as control. The results for MTT showed that the cell proliferation for 0.02% honey concentration was significantly higher (p<0.05) on day 3 whereas the proliferation were decreased for 1% honey and 5% honey concentration (p<0.05) than control on all the 3 days. There was increased in ALP level in a similar pattern for all concentration groups from day 0 to day 7 without any significant difference compared with control. Therefore, the present data suggests that Tualang honey stimulated HPDLF proliferation at low concentrations and has an inhibitory effect at high concentrations. However, its role in osteoblastic differentiation requires further investigation.
  3. Evaluation of TNF-α and IL-6 in saliva among diabetic retinopathy patients in East Coast Malaysia
    Khairul-Anwar I, Wan-Nazatul-Shima S, Siti-Lailatul-Akmar Z, Siti-Azrin AH, Zunaina E
    Trop Med Int Health, 2022 Jan 19.
    PMID: 35048479 DOI: 10.1111/tmi.13724
    OBJECTIVE: To compare tumour necrosis factor-alpha (TNF) and interleukin (IL)-6 levels in saliva between different stages of diabetic retinopathy (DR).

    METHODS: This comparative cross-sectional study was conducted between January 2018 and November 2020. This study included diabetes mellitus (DM) patients with no DR, non-proliferative DR (NPDR), and proliferative DR (PDR). None of the patients with DM were included in the control group. Unstimulated saliva samples were then collected. TNF-α and IL-6 levels were measured.

    RESULTS: Altogether, 120 patients were included in the study (DM without DR, 33 patients; DM with NPDR, 30 patients; DM with PDR, 32 patients; non-DM, 25 patients). The mean IL-6 level in saliva was significantly higher in the DM group (0.033 ± 0.005 pg/ml) than in the non-DM group (0.027 ± 0.001 pg/ml) (p 

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