MyMedR

Migrant-native socioeconomic differences in a major metropolitan area of Peninsular Malaysia: its implications on migration policy in a multiethnic society

Soon L

J Dev Areas, 1978;13(1):35-48.

PMID: 12310729

Fulltext Procidentia--surgical management

Soon LE

Med J Malaysia, 1988 Dec;43(4):340-3.

PMID: 3241599

Parental bonding, depressive experiences, and symptomology: An investigation among college students in Malaysia

Yen J, Tam CL, Lee SL

Psych J, 2021 Aug;10(4):574-586.

PMID: 33928765 DOI: 10.1002/pchj.450

This study examined the perceptions of parental bonding, depressive experiences of self-criticism and dependency, and the current level of depressive symptomology among 212 college students from Sabah, Malaysia. The participants completed the brief version of the Parental Bonding Instrument, the Reconstructed Depressive Experiences Questionnaire, and the Patient Health Questionnaire. The results showed significant direct effects of maternal care, maternal overprotection, paternal care, self-criticism, and dependency on depressive symptomology. In contrast, the indirect effects of self-criticism and dependency on the relationship between parental bonding and depressive symptomology were not significant. These findings were in line with previous studies that have highlighted the significance of parent-child bonding, self-criticism, and dependency in the development of depressive symptomology. However, they contradicted previous results on the significant indirect effects of self-criticism and dependency. This study highlights the importance of parental care and overprotection, as they can predict the manifestation of depressive symptomology at a later stage in life.

ABO grouping studies of human seminal stains on fabrics

Sinnapa S, Soon LS

Med J Malaya, 1970 Jun;24(4):278-86.

PMID: 4096943

Enteropathogenic Escherichia coli diarrhoea in Malaysian children

Jegathesan M, Singh RB, Kanaganayagy M, Soon LE

Southeast Asian J. Trop. Med. Public Health, 1975 Mar;6(1):61-7.

PMID: 1096307

The bacterial causes of diarrhoea in Malaysia

Jegathesan M, Singh RB, Kanaganayagi M, Soon LE

Med J Malaysia, 1976 Sep;31(1):46-56.

PMID: 799233

Fulltext Phylogeographical pattern and evolutionary history of an important Peninsular Malaysian timber species, Neobalanocarpus heimii (Dipterocarpaceae)

Tnah LH, Lee SL, Ng KK, Lee CT, Bhassu S, Othman RY

J Hered, 2013 Jan-Feb;104(1):115-26.

PMID: 23132907 DOI: 10.1093/jhered/ess076

Tectonic movements, climatic oscillations, and marine transgressions during the Cenozoic have had a dramatic effect on the biota of the tropical rain forest. This study aims to reveal the phylogeography and evolutionary history of a Peninsular Malaysian endemic tropical timber species, Neobalanocarpus heimii (Dipterocarpaceae). A total of 32 natural populations of N. heimii, with 8 samples from each population were investigated. Fifteen haplotypes were identified from five noncoding chloroplast DNA (cpDNA) regions. Overall, two major genealogical cpDNA lineages of N. heimii were elucidated: a widespread southern and a northern region. The species is predicted to have survived in multiple refugia during climatic oscillations: the northwestern region (R1), the northeastern region (R2), and the southern region (R3). These putative glacial refugia exhibited higher levels of genetic diversity, population differentiation, and the presence of unique haplotypes. Recolonization of refugia R1 and R2 could have first expanded into the northern region and migrated both northeastwards and northwestwards. Meanwhile, recolonization of N. heimii throughout the southern region could have commenced from refugia R3 and migrated toward the northeast and northwest, respectively. The populations of Tersang, Pasir Raja, and Rotan Tunggal exhibited remarkably high haplotype diversity, which could have been the contact zones that have received an admixture of gene pools from the northerly and also southerly regions. As a whole, the populations of N. heimii derived from glacial refugia and contact zones should be considered in the conservation strategies in order to safeguard the long-term survival of the species.

Fulltext Risk factors of gestational diabetes mellitus in the refugee population in Gaza Strip: a case-control study

AlKasseh AS, Zaki NM, Aljeesh YI, Soon LK

East Mediterr Health J, 2014 Jan 09;19 Suppl 3:S12-8.

PMID: 24995734

To determine the risk factors of gestational diabetes mellitus in refugee populations in the Gaza Strip, a retrospective case-control study was performed between March and June 2011 in the United Nations Relief and Works Agency (UNRWA) primary health care clinics. Data were collected on maternal sociodemographics and the prevalence of diagnosed GDM according to World Health Organization criteria from clinics where postnatal Palestinian refugee women had been diagnosed with GDM during previous pregnancies, and non-GDM women were used as controls. Sociodemographic characteristics, pre-pregnancy body-mass index (BMI), obstetrics history and family history of diabetes were used as study variables. In total, 189 incident cases of GDM were identified. The most significant risk factors for GDM were: history of miscarriage more than once; overweight before pregnancy; history of stillbirth; history of caesarean birth; and positive family history of diabetes mellitus.

Bacterial enteropathogens in Malaysian shellfish

Jegathesan M, Wah LT, Soon LE, Su Har D, Boo Liat L

Trop Geogr Med, 1976 Jun;28(2):91-5.

PMID: 788266

Three species of commonly eaten shellfish found in Malaysian coastal waters were examined for the presence of common bacterial enteropathogens. Vibrio parahaemolyticus, non-agglutinating vibrios, and various serotypes of enteropathogenic E. coli were isolated from a large proportion of them. Salmonella were isolated in two instances. High colony counts with evidence of faecal contamination indicated the strong possibility of pulltion being the cause for the presence of these enteropathogens. Methods of cooking and eating these shellfish enhance their likelihood of acting as vehicles of diarrhoeal disease.

Study of low salt diet in hypertensive patients with chronic kidney disease

Koh KH, Wei-Soon LH, Jun L, Lui-Sian LN, Hui-Hong CT

Med J Malaysia, 2018 12;73(6):376-381.

PMID: 30647207

INTRODUCTION: The efficacy of blood pressure (BP) reduction with salt restriction in CKD subjects and its sustainability is not well established.

METHODS: We enrolled 75 hypertensive patients with CKD into one-month salt restricting diet. 24-hour urinary sodium and potassium was measured to verify their salt intake followed by 1½ year follow-up.

RESULTS: Their creatinine clearance was 43 ± standard deviation 33ml/min/1.73m2. Urinary Na excretion (24HUNa) was 173±129mmol/day, reducing to 148±81 by 31±6 day. Mean, systolic and diastolic BP (MBP, SBP, DBP) were reduced from 102±9 to 97±11 (p<0.001), 148±10 to 139±16 (p<0.001), 78±12 to 75±12 mmHg (p=0.012) respectively. Moderate correlations were shown between reductions in 24-hour urinary Na and MBP, SBP, DBP: r=0.366, 0.260, 0.365; p=0.001, 0.025, 0.001; whereas 24-hour urinary Na-K ratio showed mild correlation. Subjects have some tendency to drift back to previous Na intake profile in follow-up and thus repetitive education is necessary. In subanalysis, 34 subjects with baseline 24HUNa >150 mmol/day, benefited significantly with MBP, SBP, DBP reduction from 102±9 to 95±9 (p=0.001), 146±10 to 135±14 mmHg (p=0.001), 80±11 to 75±11 mmHg (p=0.002) in line with 24HUNa reduction from 253±154 to 163±87mmol/day (p=0.004) and urinary protein-creation ratio reduction from geometric mean of 95 to 65 g/mol. Thirty five subjects with 24HUNa reduction of >20mmol/day have significant reduction in MBP, SBP, DBP: -8 vs -2, -15 vs -4, -5 vs -2 mmHg (p=0.027, 0.006, 0.218) and urinary protein-creatinine ratio: -82 vs 2g/mol (p=0.030) compared to the other forty subjects.

CONCLUSION: Quantification of 24-hour urinary Na helps in predicting potential antihypertensive effect with dietary salt reduction of CKD subjects. Salt restriction reduces BP especially in patients with estimated daily sodium intake of >150mmol/day. Reduction in sodium intake beyond 20mmol/day reduced both BP and proteinuria.

Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms

Soon L, Ng PQ, Chellian J, Madheswaran T, Panneerselvam J, Gupta G, et al.

J Environ Pathol Toxicol Oncol, 2019;38(3):205-216.

PMID: 31679308 DOI: 10.1615/JEnvironPatholToxicolOncol.2019029397

Artemisia vulgaris is a traditional Chinese herb believed to have a wide range of healing properties; it is traditionally used to treat numerous health ailments. The plant is commonly called mugwort or riverside wormwood. The plant is edible, and in addition to its medicinal properties, it is also used as a culinary herb in Asian cooking in the form of a vegetable or in soup. The plant has garnered the attention of researchers in the past few decades, and several research studies have investigated its biological effects, including antioxidant, anti-inflammatory, anticancer, hypolipidemic, and antimicrobial properties. In this review, various studies on these biological effects are discussed along with the tests conducted, compounds involved, and proposed mechanisms of action. This review will be of interest to the researchers working in the field of herbal medicine, pharmacology, medical sciences, and immunology.

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