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  1. Fulltext Single-center experience of von Willebrand disease (vWD) among patients with menorrhagia: a diagnosis which could be missed
    Hassan R, Yusof WA, Hussain NH, Abdullah WZ
    Indian J Hematol Blood Transfus, 2012 Sep;28(3):157-61.
    PMID: 23997452 DOI: 10.1007/s12288-011-0135-6
    Menorrhagia is one of the gynecological complaints, seen in women of reproductive age. In majority of cases no organic pathology is found. To date there is no consensus on application of von Willebrand disease (vWD) testing as part of the routine investigations in menorrhagia. Diagnosis of vWD is challenging. It is complicated by intra-individual variations in von Willebrand antigen, activity, and factor VIII levels due to fluctuation of these factor levels during the menstrual cycle or hormonal therapy. The aim of this study is to detect vWD presenting with menorrhagia among Malays attending gynecology clinic by using a standard panel of haemostatic profiles. Thirty Malay patients attending gynecology clinic with unexplained menorrhagia were included in this study. Haemostatic profile such as platelet count, prothrombin time, activated partial thromboplastin time (APTT), factor VIII assay, von Willebrand factor antigen, and von Willebrand factor activity, and collagen binding assay were measured in all patients. Pre- and post hormonal haemostatic profiles were also performed in the patients diagnosed as vWD. All patients had normal APTT. Based on von Willebrand factor work-up, vWD was diagnosed in four patients (13.3%). Three of them were Type 1 and the other one was Type 2M. Investigation for vWD is essential in patients with menorrhagia and thus the laboratories performing vWD testing should provide a complete panel of diagnostic work-up in order to reduce the interpretation error. Screening for vWD should be performed before hormonal treatment as haemostatic profile post treatment could mask the diagnosis.
    Study site: Gynaecology clinic, Hospital of Universiti Sains Malaysia (HUSM), Kelantan, Malaysia
  2. Hemophagocytic Lymphohistiocytosis: A Case Series From a Tertiary State Hospital in Malaysia and a Review of Current Literature
    Khaw JY, Gan WF, Chong HC, Lau NS, Wan Yusof WA
    Cureus, 2024 Jun;16(6):e61636.
    PMID: 38966453 DOI: 10.7759/cureus.61636
    INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a lethal emergency. Delays in diagnosis and treatment are detrimental to the health of patients. Classical clinical manifestations of HLH include fever, cytopenia, liver dysfunction, central nervous system involvement, and coagulopathy.

    METHODS: We report seven cases of secondary HLH in adults diagnosed from a total of 1200 bone marrow aspiration and trephine biopsy (BMAT) examinations in our center, with various presentations and underlying triggers including infection, malignancy, and autoimmune disease.

    RESULTS: HLH can present with non-specific signs and symptoms.

    CONCLUSION: Early recognition of HLH is crucial to enable the commencement of therapy as early as possible to prevent mortality resulting from multi-organ failure.

  3. Fulltext Clinical predictors of acute kidney injury in children with acute post-streptococcal glomerulonephritis: a tertiary centre experience
    Wan Yusof WA, Yaacob NM, Nasir A, Yusoff S, Ilias MI
    Singapore Med J, 2025 Jan 01;66(1):54-57.
    PMID: 36695277 DOI: 10.4103/singaporemedj.SMJ-2021-092
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