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Radiation dose associated with cerebral CT angiography and CT perfusion: an experimental phantom study

Sabarudin A, Yusof MZ, Mohamad M, Sun Z

Radiat Prot Dosimetry, 2014 Dec;162(3):316-21.
PMID: 24255172 DOI: 10.1093/rpd/nct280

A study on the radiation dose associated with cerebral CT angiography (CTA) and CT perfusion (CTP) was conducted on an anthropomorphic phantom with the aim of estimating the effective dose (E) and entrance skin dose (ESD) in the eyes and thyroid gland during different CTA and CTP protocols. The E was calculated to be 0.61 and 0.28 mSv in CTA with 100 and 80 kV(p), respectively. In contrast, CTP resulted in an estimated E of 2.74 and 2.07 mSv corresponding to 40 and 30 s protocols, respectively. The eyes received a higher ESD than the thyroid gland in all of these protocols. The results of this study indicate that combining both CTA and CTP procedures are not recommended in the stroke evaluation due to high radiation dose. Application of modified techniques in CTA (80 kV(p)) and CTP (30 s) is highly recommended in clinical practice for further radiation dose reduction.

Matched MeSH terms: Brain/radiation effects
MRI-based brain structural changes following radiotherapy of Nasopharyngeal Carcinoma: A systematic review

Voon NS, Lau FN, Zakaria R, Md Rani SA, Ismail F, Manan HA, et al.

Cancer Radiother, 2021 Feb;25(1):62-71.
PMID: 33414057 DOI: 10.1016/j.canrad.2020.07.008

PURPOSE: Nasopharyngeal carcinoma (NPC) radiotherapy (RT) irradiates parts of the brain which may cause cerebral tissue changes. This study aimed to systematically review the brain microstructure changes using MRI-based measures, diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI) and voxel-based morphometry (VBM) and the impact of dose and latency following RT.
METHODS: PubMed and Scopus databases were searched based on PRISMA guideline to determine studies focusing on changes following NPC RT.
RESULTS: Eleven studies fulfilled the inclusion criteria. Microstructural changes occur most consistently in the temporal region. The changes were correlated with latency in seven studies; fractional anisotropy (FA) and gray matter (GM) volume remained low even after a longer period following RT and areas beyond irradiation site with reduced FA and GM measures. For dosage, only one study showed correlation, thus requiring further investigations.
CONCLUSION: DTI, DKI and VBM may be used as a surveillance tool in detecting brain microstructural changes of NPC patients which correlates to latency and brain areas following RT.

Matched MeSH terms: Brain/radiation effects*
Central nervous system prophylaxis in childhood acute lymphoblastic leukaemia: CT brain appearance after 3 years continuous complete remission in 36 Malaysian children

Nuruddin RN, Daud AB, Lin HP

Australas Radiol, 1988 Feb;32(1):44-9.
PMID: 3165633
Matched MeSH terms: Brain/radiation effects
Radiofrequency electromagnetic radiation-induced behavioral changes and their possible basis

Narayanan SN, Jetti R, Kesari KK, Kumar RS, Nayak SB, Bhat PG

Environ Sci Pollut Res Int, 2019 Oct;26(30):30693-30710.
PMID: 31463749 DOI: 10.1007/s11356-019-06278-5

The primary objective of mobile phone technology is to achieve communication with any person at any place and time. In the modern era, it is impossible to ignore the usefulness of mobile phone technology in cases of emergency as many lives have been saved. However, the biological effects they may have on humans and other animals have been largely ignored and not been evaluated comprehensively. One of the reasons for this is the speedy uncontrollable growth of this technology which has surpassed our researching ability. Initiated with the first generation, the mobile telephony currently reaches to its fifth generation without being screened extensively for any biological effects that they may have on humans or on other animals. Mounting evidences suggest possible non-thermal biological effects of radiofrequency electromagnetic radiation (RF-EMR) on brain and behavior. Behavioral studies have particularly concentrated on the effects of RF-EMR on learning, memory, anxiety, and locomotion. The literature analysis on behavioral effects of RF-EMR demonstrates complex picture with conflicting observations. Nonetheless, numerous reports suggest a possible behavioral effect of RF-EMR. The scientific findings about this issue are presented in the current review. The possible neural and molecular mechanisms for the behavioral effects have been proposed in the light of available evidences from the literature.

Matched MeSH terms: Brain/radiation effects*