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Partial ablation of uropygial gland effect on carcass characteristics of Akar Putra chicken

Jawad HS, Idris LH, Bakar ZB, Kassim AB

Poult Sci, 2016 Aug 01;95(8):1966-71.
PMID: 27081194 DOI: 10.3382/ps/pew125

This study evaluated the effect of partial uropygialectomy (PU) on carcass traits of male and female Akar Putra chickens. Sixty chicks of each sex were evenly distributed into 5 treatment groups with 3 replicates per group containing 4 males and 4 females each, and reared for 12 wk. Homogeneity of the groups was satisfied with regard to the parity. Experimental treatments consisted of a control treatment (T1), and partial ablation of the uropygial gland was applied on the second, third, fourth, and fifth treatments at 3, 4, 5, and 6 wk of age, respectively. The chickens were fed ad libitum the same diets (1 to 13 d: starter; 14 d to slaughter: finisher). On the last d of the experiment, 12 birds were randomly selected from each treatment group (2 males and 2 females per replicate) and slaughtered to determine carcass characteristics, which included carcass weight, dressing percentage with or without eating giblets, and the relative weights of heart, liver, gizzard, thighs, wings, breast, back, and neck. From the results of the study, it was shown that the partial ablation of the uropygial gland at all ages had certain dependent effects concerning some carcass parameters, as shown by higher breast and back relative weights in males and breast relative weight in females. As a consequence, a positive effect also was noticed regarding the carcass morphology in terms of the increase in dressing percentage with or without eating giblets thus leading to an increase in the body weight and carcass weight. Furthermore, the best result was obtained in the second treatment when PU was applied at 3 wk of age compared with other experimental groups. Moreover, the current study provides a novel and economic alternative to enhance the body performance of poultry in general and Akar Putra chicken particularly.

Matched MeSH terms: Sebaceous Glands/surgery*
Blood group in relation to oral Fordyce's granules and serum cholesterol level

Diajil AR, Goodson ML

J Oral Pathol Med, 2023 Jul;52(6):521-527.
PMID: 37038041 DOI: 10.1111/jop.13432

BACKGROUND: The ABO and Rh systems are the most commonly used blood-group systems used to classify blood group globally. A number of studies have shown that ABO blood groups may be associated with an increased serum cholesterol levels which in turn may be related to the presence of oral Fordyce spots or granules. Oral Fordyce's granules are ectopic sebaceous glands within the oral cavity and are visible through epithelium. The aim of this study was to assess the relationship between ABO and Rhesus blood groups and the presence of oral Fordyce's granules and serum cholesterols level by gender.
METHODS: Following ethical approval and informed consent, 124 subjects were recruited into this cross-sectional study. Clinical oral examination assessed the number of Fordyce's granules and blood samples were collected to determine the serum cholesterol and ABO/Rh blood-group systems of individual subjects.
RESULTS: Blood group AB+ showed the highest mean of oral Fordyce's granules number and serum cholesterol level but this was not statistically significant compared to other blood groups. Female subjects in this study who were AB+ were had significantly higher serum cholesterol levels than males.
CONCLUSION: This study indicates an association between ABO blood group, serum cholesterol level and mean number of oral Fordyce's granules. A larger sample size in a future study is required to ascertain whether number of Fordyce's granules is an important measure of serum cholesterol, but the study does show that for AB+ individuals, females may have higher serum cholesterol than males.

Matched MeSH terms: Sebaceous Glands/pathology
Fulltext Leonine facies

Low QJ, Cheo SW, Yap WYE

Indian J Dermatol Venereol Leprol, 2020 2 19;87(4):589-591.
PMID: 32068196 DOI: 10.4103/ijdvl.IJDVL_983_18
Matched MeSH terms: Sebaceous Glands/pathology*
Acne vulgarism treatment using ultra-short laser pulse generated by micro- and nano-ring resonator system

Jalil MA, Phelawan J, Aziz MS, Saktioto T, Ong CT, Yupapin PP

Artif Cells Nanomed Biotechnol, 2013 Apr;41(2):92-7.
PMID: 22991968 DOI: 10.3109/10731199.2012.700519

Acne vulgaris is adebilitating dermatologic disease, and is conventionally treated by laser therapy using a microring resonator system. An evolving understanding of laser-tissue interactions involving Propioni bacterium acneproducing porphyrins, and the development of lasers to target the sebaceous glands, has led to the development of an escalating number of laser light for acne treatment. The results show that the full width at half maximum of the proposed laser pulse of 0.15 nm can be generated using a microring resonator system. The power of the laser is 200 W and the wavelength laser is 1,032 nm, which is proposed as a treatment of acne vulgaris diseases.

Matched MeSH terms: Sebaceous Glands/radiation effects*
Reply to comments to "Letter to the Editor: comment on Azmahani et al. steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions"

Azmahani A, Nakamura Y, Felizola SJ, Ozawa Y, Ise K, Inoue T, et al.

J Steroid Biochem Mol Biol, 2016 Jan;155(Pt A):178-80.
PMID: 26455405 DOI: 10.1016/j.jsbmb.2015.09.028
Matched MeSH terms: Sebaceous Glands/metabolism*
Keloids - the sebum hypothesis revisited

Fong EP, Bay BH

Med Hypotheses, 2002 Apr;58(4):264-9.
PMID: 12027517

The aetiology of the keloid scar has not been completely elucidated. Numerous hypotheses have been proposed in the past to explain the unusual characteristics of the keloid scar. While we do know that there is excessive and ongoing collagen-deposition, the exact triggering stimulus is a subject of conjecture. We present some of our photographic records of keloids and electron microscopic findings of keloid edges and reiterate the sebum hypothesis. We also attempt to explain the features of keloids in the light of the present knowledge of immunology and cell biology.

Matched MeSH terms: Sebaceous Glands/secretion; Sebaceous Glands/ultrastructure
Fulltext Histological changes of immediate skin expansion of the distal limb of rats

Ali AK, Abubakar AA, Kaka U, Radzi Z, Khairuddin NH, Yusoff MSM, et al.

Vet World, 2018 Dec;11(12):1706-1711.
PMID: 30774262 DOI: 10.14202/vetworld.2018.1706-1711

Aim: Tissue expansion is an applicable technique to reconstruct many surgical defects. The aim of this research was to evaluate the histological changes caused by immediate skin tissue expansion in rats as an animal model.
Materials and Methods: Immediate skin tissue expansion in 18 adult female rats was performed using three different sizes (small, medium, and big) of polymethylmethacrylate tissue expanders at the dorsal surface of the metatarsal area of the right limb. The contralateral limb was served as the control. The tissue expanders were surgically implanted and kept for 15 days.
Results: The immediate skin expansion resulted in histological changes such as the increased thickness of the epidermal layer, the reduction of the dermal layer, an elevated number of fibroblast as well as increased vascularity. Furthermore, skin adnexal structures such as hair follicles and sebaceous glands were farther apart.
Conclusion: The rat skin was able to rapidly adjust and compensate against a specific range of immediate mechanical expansion. The histological changes suggest that the tissues were prepared to withstand the increased external forces, in addition to create possibly additional skin in a relatively short-term period.

Matched MeSH terms: Sebaceous Glands
Steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions

Azmahani A, Nakamura Y, Felizola SJ, Ozawa Y, Ise K, Inoue T, et al.

J Steroid Biochem Mol Biol, 2014 Oct;144 Pt B:268-79.
PMID: 25090634 DOI: 10.1016/j.jsbmb.2014.07.010

The sebaceous gland is a major site of steroid synthesis in human skin, but details of the status of steroidogenic enzymes and their regulation in human sebaceous glands under normal and pathological conditions have rarely been reported. Therefore, in this study, we examined the status of steroidogenic enzymes, sex steroid receptors and transcription factors in human sebaceous glands under normal and pathological conditions to explore their possible roles in in situ steroid production in human skin. Immunohistochemical analysis was performed in a total of 59 human skin specimens, including 22 normal human sebaceous glands, 12 with sebaceous nevus, 12 with sebaceous gland hyperplasia, 3 with sebaceoma and 10 with sebaceous carcinoma. Immortalised human SZ95 sebocytes were treated with forskolin or vehicle for 3h, 6h, 12h or 24h, and the mRNA levels of steroidogenic enzymes were evaluated at each time point using quantitative RT-PCR (qPCR). The results of immunohistochemistry demonstrated the immunoreactivity of 3β-HSD1, CYP11A1, StAR, 17β-HSD5, CYP17A1, 5α-red1, PRB, AR and NGFI-B in normal human sebaceous gland, with lower levels of expression in pathological sebaceous glands. The results of the in vitro study also indicated that the expression levels of 3β-HSD1, CYP11A1, StAR, 5α-red1 and NGFI-B were elevated by forskolin. 3β-HSD1 and other steroidogenic enzymes were expressed in sebaceous glands resulting in in situ androgen and progesterone synthesis and their functions.

Matched MeSH terms: Sebaceous Glands/metabolism*
Cutaneous adnexal neoplasms in biopsy specimens processed in the Department of Pathology, University of Malaya

Jayalakshmi P, Looi LM

Ann Acad Med Singap, 1996 Jul;25(4):522-5.
PMID: 8893922

A review of consecutive biopsies of adnexal tumours from 112 patients, received by the Department of Pathology, University of Malaya, over a 13-year period was undertaken. The age range of the patients was from 1 to 84 years, with a mean of 29.8 years. Thirty-three (32%) patients were under 20 years of age. There were 68 females with a male to female ratio of 1.0:1.5. In 105 cases (93.7%), the neoplasm was solitary. The tumour measured less than 2 cm in the largest dimension in 103 cases (92%). The common sites of occurrence were the head and neck region (59%) and extremities (25%). Neoplasms of hair follicle origin accounted for 63.4% (71 cases) of all lesions. Intra-tumour deposition of amyloid was noted in one of the 14 cases of trichoepithelioma.

Matched MeSH terms: Sebaceous Glands/pathology