MyMedR

Clinical correlates with immunopathogenesis in dengue haemorrhagic fever/dengue shock syndrome

Tan PS

Malays J Pathol, 1993 Jun;15(1):41-7.

PMID: 8277789

Matched MeSH terms: Shock, Septic/etiology*

Management of dengue haemorrhagic fever/dengue shock syndrome

Lum LC

Malays J Pathol, 1993 Jun;15(1):29-33.

PMID: 8277786

Matched MeSH terms: Shock, Septic/etiology*

Fulltext Paediatric melioidosis with septic shock in a previously-well child

Kandasamy Y, Somasundaram P

Singapore Med J, 2007 Apr;48(4):e109-10.

PMID: 17384864

We present a previously-healthy 12-year old girl from a rural community and who was admitted to a district general hospital in Malaysia with coagulopathy and septic shock. Despite receiving intensive care, she succumbed to her illness. Blood cultures grew Burkholderia pseudomallei. Melioidosis is an unusual cause of paediatric Gram-negative sepsis among children in Malaysia.

Matched MeSH terms: Shock, Septic/etiology*

Critical care aspects of dengue haemorrhagic fever/dengue shock syndrome

Yong BH

Malays J Pathol, 1993 Jun;15(1):35-9.

PMID: 8277788

Matched MeSH terms: Shock, Septic/etiology*

Fulltext Unintended Consequences: Fluid Resuscitation Worsens Shock in an Ovine Model of Endotoxemia

Byrne L, Obonyo NG, Diab SD, Dunster KR, Passmore MR, Boon AC, et al.

Am J Respir Crit Care Med, 2018 10 15;198(8):1043-1054.

PMID: 29882682 DOI: 10.1164/rccm.201801-0064OC

RATIONALE: Fluid resuscitation is widely considered a life-saving intervention in septic shock; however, recent evidence has brought both its safety and efficacy in sepsis into question.

OBJECTIVES: In this study, we sought to compare fluid resuscitation with vasopressors with the use of vasopressors alone in a hyperdynamic model of ovine endotoxemia.

METHODS: Endotoxemic shock was induced in 16 sheep, after which they received fluid resuscitation with 40 ml/kg of 0.9% saline or commenced hemodynamic support with protocolized noradrenaline and vasopressin. Microdialysis catheters were inserted into the arterial circulation, heart, brain, kidney, and liver to monitor local metabolism. Blood samples were recovered to measure serum inflammatory cytokines, creatinine, troponin, atrial natriuretic peptide, brain natriuretic peptide, and hyaluronan. All animals were monitored and supported for 12 hours after fluid resuscitation.

MEASUREMENTS AND MAIN RESULTS: After resuscitation, animals that received fluid resuscitation required significantly more noradrenaline to maintain the same mean arterial pressure in the subsequent 12 hours (68.9 mg vs. 39.6 mg; P = 0.04). Serum cytokines were similar between groups. Atrial natriuretic peptide increased significantly after fluid resuscitation compared with that observed in animals managed without fluid resuscitation (335 ng/ml [256-382] vs. 233 ng/ml [144-292]; P = 0.04). Cross-sectional time-series analysis showed that the rate of increase of the glycocalyx glycosaminoglycan hyaluronan was greater in the fluid-resuscitated group over the course of the study (P = 0.02).

CONCLUSIONS: Fluid resuscitation resulted in a paradoxical increase in vasopressor requirement. Additionally, it did not result in improvements in any of the measured microcirculatory- or organ-specific markers measured. The increase in vasopressor requirement may have been due to endothelial/glycocalyx damage secondary to atrial natriuretic peptide-mediated glycocalyx shedding.

Matched MeSH terms: Shock, Septic/etiology

Fulltext Multiple organ failure and septic shock in disseminated tuberculosis

Lim KH, Chong KL

Singapore Med J, 1999 Mar;40(3):176-8.

PMID: 10402899

The diagnosis of disseminated tuberculosis should be entertained in all patients with unexplained fever associated with hepatomegaly and/or splenomegaly with or without anomalies in liver function tests and haemogram. It should be considered as a possible cause of septic shock especially in patients with typical risk factors such as advanced age, diabetes, alcoholism or immunosuppression. Prompt therapy could be life saving in an otherwise potentially fatal condition. It is therefore appropriate to initiate anti-tuberculosis treatment as soon as such a diagnosis is suspected and not await final confirmation.

Matched MeSH terms: Shock, Septic/etiology*

Fulltext Purpura Fulminans: A rare presentation of Streptococcus Pneumoniae infection

Teo HG, Wong JY, Ting TLL

BMJ Case Rep, 2017 Oct 20;2017.

PMID: 29054893 DOI: 10.1136/bcr-2017-221150

A previously healthy man presented with fever for 2 days and rapidly progressive purpuric rash for 1 day. He progressed into hypotension, disseminated intravascular coagulation and refractory shock despite resuscitation and early antibiotic commencement. Blood culture grew Streptococcus pneumoniae This case report highlights the fact that purpura fulminans can be a rare presentation of S. pneumoniae infection as well.

Matched MeSH terms: Shock, Septic/etiology

Fulltext Travel-related Streptococcal toxic shock syndrome caused by emm type 78 Streptococcus pyogenes

Tappe D, Schulze MH, van der Linden M, Ziegler U, Müller A, Stich A

J Clin Microbiol, 2011 Aug;49(8):3094-5.

PMID: 21632896 DOI: 10.1128/JCM.02623-10

Streptococcal toxic shock syndrome is a serious health problem in developed and developing countries. We here report a case of severe protracted disease after a minor skin infection in a young traveler returning from West Malaysia which was caused by an unusual emm-type strain harboring speG and smeZ superantigen genes.

Matched MeSH terms: Shock, Septic/etiology

Displaying all 8 publications