MyMedR

Yaws was detected in a six-member family in the southern Malaysia state of Johor. This stresses the need to be vigilant against a long-forgotten disease of childhood which was of great public health concern in the past.

Matched MeSH terms: Yaws/diagnosis; Yaws/epidemiology*; Yaws/therapy

The yaws or "puru" of Malaya. Its treatment and eradiaction

Viswalingam A

Malayan Medical Journal, 1926;1:22-4.

Matched MeSH terms: Yaws

Yaws in Borneo, not connected with syphilis

Smith F

Lancet, 1894;144:910.

DOI: 10.1016/S0140-6736(02)02047-0

Matched MeSH terms: Yaws

Yaws control in Netherlands New Guinea

HUGGINS DR

Med J Malaya, 1958 Jun;12(4):618-21.

PMID: 13577155

Matched MeSH terms: Yaws/prevention & control*

Yaws in Malaysia

Lo EK

Rev. Infect. Dis., 1985 5 1;7 Suppl 2:S251-3.

PMID: 4012167

In 1954, with the assistance of the World Health Organization and the United Nations Children's Fund, a campaign against yaws was initiated in Malaysia with the formation of a yaws elimination unit in the Ministry of Health. Between 1954 and 1975, the reported annual incidence of yaws fell from 140.85 to 1.25 per 100,000 population. When rates dropped to less than two per 100,000, the program was merged with the general health services. Currently when cases are reported, contacts are traced, school and village surveys are carried out, and appropriate treatment is given. The major problems facing the control program today are a loss of interest in control activities; a smaller number of health workers experienced in the diagnosis, management, and control of the disease; and a growing reluctance to treat asymptomatic contacts with penicillin for fear of anaphylactoid reactions. Despite these problems, it is not an unreasonable expectation that, with continued stimulation from the individuals responsible for infectious disease control, yaws will eventually be eliminated.

Matched MeSH terms: Yaws/epidemiology; Yaws/prevention & control*

Late yaws and optic atrophy

Mohamed KN

Ann Trop Med Parasitol, 1990 Dec;84(6):637-9.

PMID: 2076042

Matched MeSH terms: Yaws/complications*; Yaws/drug therapy

Nasal manifestations of yaws

Elango S, Palaniappan SP

Ear Nose Throat J, 1989 Nov;68(11):870, 873-5.

PMID: 2612395

Yaws is an infectious, non-venereal disease of the tropical countries, which is caused by Treponema pertenue. Gangosa and goundou were seen commonly in cases of yaws in Africa, particularly in the early part of this century. After successful WHO mass treatment campaigns, these conditions are rarely seen now. A case of yaws with gangosa, goundou, and a nasopharyngeal carcinoma is presented here for its rarity.

Matched MeSH terms: Yaws/complications*; Yaws/diagnosis

A case of yaws in Kelantan state and the value of VDRL and FTA--ABS in family studies

Ganesapillai T

Med J Malaysia, 1973 Sep;28(1):50-1.

PMID: 4273786

Matched MeSH terms: Yaws/diagnosis*

Fulltext Yaws revisited

Gip LS

Med J Malaysia, 1989 Dec;44(4):307-11.

PMID: 2520039

An outbreak of yaws consisting of ten active cases in Baling is described. Yaws should be suspected and considered in the differential diagnosis of sores in the limbs of children living in rural areas. The clinical features of yaws are highlighted to help in the recognition of the condition for those unfamiliar with the condition.

Matched MeSH terms: Yaws/diagnosis; Yaws/drug therapy; Yaws/epidemiology*

Two uncommon cases of yaws

Devota TJ

Malayan Medical Journal, 1926;1:28.

Matched MeSH terms: Yaws

Fulltext Assessing seroprevalence and associated risk factors for multiple infectious diseases in Sabah, Malaysia using serological multiplex bead assays

Chan YL, Patterson CL, Priest JW, Stresman G, William T, Chua TH, et al.

Front Public Health, 2022;10:924316.

PMID: 36388287 DOI: 10.3389/fpubh.2022.924316

BACKGROUND: Infectious diseases continue to burden populations in Malaysia, especially among rural communities where resources are limited and access to health care is difficult. Current epidemiological trends of several neglected tropical diseases in these populations are at present absent due to the lack of habitual and efficient surveillance. To date, various studies have explored the utility of serological multiplex beads to monitor numerous diseases simultaneously. We therefore applied this platform to assess population level exposure to six infectious diseases in Sabah, Malaysia. Furthermore, we concurrently investigated demographic and spatial risk factors that may be associated with exposure for each disease.

METHODS: This study was conducted in four districts of Northern Sabah in Malaysian Borneo, using an environmentally stratified, population-based cross-sectional serological survey targeted to determine risk factors for malaria. Samples were collected between September to December 2015, from 919 villages totaling 10,100 persons. IgG responses to twelve antigens of six diseases (lymphatic filariasis- Bm33, Bm14, BmR1, Wb123; strongyloides- NIE; toxoplasmosis-SAG2A; yaws- Rp17 and TmpA; trachoma- Pgp3, Ct694; and giardiasis- VSP3, VSP5) were measured using serological multiplex bead assays. Eight demographic risk factors and twelve environmental covariates were included in this study to better understand transmission in this community.

RESULTS: Seroprevalence of LF antigens included Bm33 (10.9%), Bm14+ BmR1 (3.5%), and Wb123 (1.7%). Seroprevalence of Strongyloides antigen NIE was 16.8%, for Toxoplasma antigen SAG2A was 29.9%, and Giardia antigens GVSP3 + GVSP5 was 23.2%. Seroprevalence estimates for yaws Rp17 was 4.91%, for TmpA was 4.81%, and for combined seropositivity to both antigens was 1.2%. Seroprevalence estimates for trachoma Pgp3 + Ct694 were 4.5%. Age was a significant risk factors consistent among all antigens assessed, while other risk factors varied among the different antigens. Spatial heterogeneity of seroprevalence was observed more prominently in lymphatic filariasis and toxoplasmosis.

CONCLUSIONS: Multiplex bead assays can be used to assess serological responses to numerous pathogens simultaneously to support infectious disease surveillance in rural communities, especially where prevalences estimates are lacking for neglected tropical diseases. Demographic and spatial data collected alongside serosurveys can prove useful in identifying risk factors associated with exposure and geographic distribution of transmission.

Matched MeSH terms: Yaws*

Musculoskeletal lesions in yaws

Sengupta S

Clin Orthop Relat Res, 1985 Jan-Feb;?(192):193-8.

PMID: 3967422

Yaws, a spirochetal infection that is endemic in certain tropical countries, including Malaysia, may present with various orthopedic problems. As the condition is relatively unknown, diagnosis is often missed, which leads to poor management. There are initial, early, and late phases of the disease process. By involving skin, bone, and joints, yaws can produce deep ulcerations, joint deformities, and bone destruction. Within a ten-year period in Malaysia, 14 cases of serologically proven yaws have been treated for chronic ulcers, gross joint deformities, and pathologic fractures.

Matched MeSH terms: Yaws/complications*; Yaws/diagnosis; Yaws/radiography

A curious case of gangosa

Sinnadurai C

Journal of the Malaya Branch of the British Medical Association, 1940;3:419-21.

Matched MeSH terms: Yaws

Fulltext Facial lesions resembling leprosy

Mohamed KB

Int. J. Lepr. Other Mycobact. Dis., 2001 Mar;69(1):35-7.

PMID: 11480315

Matched MeSH terms: Yaws/blood; Yaws/diagnosis

Fulltext Federated Malay States

J Trop Med Hyg, 1923;26:332-4.

Matched MeSH terms: Yaws

Fulltext Yaws in the Western pacific region: a review of the literature

Capuano C, Ozaki M

J Trop Med, 2011;2011:642832.

PMID: 22235208 DOI: 10.1155/2011/642832

Until the middle of the 20th century, yaws was highly endemic and considered a serious public health problem in the Western Pacific Region (WPR), leading to intensive control efforts in the 1950s-1960s. Since then, little attention has been paid to its reemergence. Its current burden is unknown. This paper presents the results of an extensive literature review, focusing on yaws in the South Pacific. Available records suggest that the region remains largely free of yaws except for Papua New Guinea, Solomon Islands, and Vanuatu. Many clinical cases reported recently were described as "attenuated"; advanced stages are rare. A single intramuscular injection of benzathine penicillin is still effective in curing yaws. In the Pacific, yaws may be amenable to elimination if adequate resources are provided and political commitment revived. A mapping of yaws prevalence in PNG, Solomon, and Vanuatu is needed before comprehensive country-tailored strategies towards yaws elimination can be developed.

Matched MeSH terms: Yaws

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