MyMedR

Shigellosis in Kobe City, Japan, after school excursion to Malaysia and Singapore

Kimura T, Inoue A, Kawakami Y, Shirai C

Jpn J Infect Dis, 2006 Aug;59(4):274.

Matched MeSH terms: Shigella sonnei/isolation & purification*

Fulltext Outer membrane proteins analysis of Shigella sonnei and evaluation of their antigenicity in Shigella infected individuals

Harikrishnan H, Banga Singh KK, Ismail A

PLoS One, 2017;12(8):e0182878.

PMID: 28846684 DOI: 10.1371/journal.pone.0182878

Bacillary dysentery caused by infection with Shigella spp. remains as serious and common health problem throughout the world. It is a highly multi drug resistant organism and rarely identified from the patient at the early stage of infection. S. sonnei is the most frequently isolated species causing shigellosis in industrialized countries. The antigenicity of outer membrane protein of this pathogen expressed during human infection has not been identified to date. We have studied the antigenic outer membrane proteins expressed by S. sonnei, with the aim of identifying presence of specific IgA and IgG in human serum against the candidate protein biomarkers. Three antigenic OMPs sized 33.3, 43.8 and 100.3 kDa were uniquely recognized by IgA and IgG from patients with S. sonnei infection, and did not cross-react with sera from patients with other types of infection. The antigenic proteome data generated in this study are a first for OMPs of S. sonnei, and they provide important insights of human immune responses. Furthermore, numerous prime candidate proteins were identified which will aid the development of new diagnostic tools for the detection of S. sonnei.

Matched MeSH terms: Shigella sonnei/immunology*; Shigella sonnei/isolation & purification; Shigella sonnei/metabolism

Antimicrobial susceptibility and pulsed-field gel electrophoresis of Shigella sonnei strains in Malaysia (1997-2000)

Hoe CH, Yasin RM, Koh YT, Thong KL

J Appl Microbiol, 2005;99(1):133-40.

PMID: 15960673

Antimicrobial resistance of Shigella sonnei from Malaysia was determined and subtyping was carried by pulsed-field gel electrophoresis (PFGE) to assess the extent of genetic diversity of these strains.

Matched MeSH terms: Shigella sonnei/drug effects; Shigella sonnei/genetics*

Fulltext Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases

Koh XP, Chiou CS, Ajam N, Watanabe H, Ahmad N, Thong KL

BMC Infect Dis, 2012;12:122.

PMID: 22606962 DOI: 10.1186/1471-2334-12-122

Shigellosis is a major public health concern worldwide, especially in developing countries. It is an acute intestinal infection caused by bacteria of the genus Shigella, with a minimum infective dose as low as 10-100 bacterial cells. Increasing prevalence of Shigella sonnei as the etiologic agent of shigellosis in Malaysia has been reported. As there is limited information on the genetic background of S. sonnei in Malaysia, this study aimed to characterize Malaysian S. sonnei and to evaluate the prospect of using multilocus variable-number tandem-repeat (VNTR) analysis (MLVA) for subtyping of local S. sonnei.

Matched MeSH terms: Shigella sonnei/classification*; Shigella sonnei/genetics; Shigella sonnei/isolation & purification*

Isolation of a Plesiomonas shigelloides in Malaysia

Ampalam SD, Fang L

Med J Malaya, 1971 Jun;25(4):282-4.

PMID: 4261301

Matched MeSH terms: Shigella sonnei/isolation & purification

Fulltext A small RNA decreases the sensitivity of Shigella sonnei to norfloxacin

Gan IN, Tan HS

BMC Res Notes, 2019 Feb 21;12(1):97.

PMID: 30791948 DOI: 10.1186/s13104-019-4124-4

OBJECTIVES: Shigella is a human pathogen that causes shigellosis, an acute invasive intestinal infection. Recent studies in the model bacterium Escherichia coli (E. coli) provided evidence that small regulatory RNAs (sRNAs) can contribute to antimicrobial resistance or susceptibility. One of the sRNAs is SdsR, which increases sensitivity of E. coli against fluoroquinolone by repressing the drug efflux pump, TolC. However, no reports exist about the effect of SdsR on fluoroquinolone resistance in Shigella sonnei (S. sonnei). In this study, we established the effect of SdsR on the sensitivity of S. sonnei to norfloxacin.

DATA DESCRIPTION: We tested the effects of SdsR and SdsRv2 on fluoroquinolone resistance in S. sonnei in vivo. SdsRv2 is a synthetic version which promotes higher binding stability to tolC mRNA. Overexpression of either SdsR or SdsRv2 lowers the expression of tolC mRNA. Interestingly, SdsR and SdsRv2 promote the growth of S. sonnei in the presence of a sub-inhibitory concentration of norfloxacin. Mutant carrying SdsRv2 showed the highest growth advantage. This phenotype is opposite to the effect of SdsR reported in E. coli. This study is an example that demonstrates the difference in the phenotypic effect of a highly conserved sRNA in two closely related bacteria.

Matched MeSH terms: Shigella sonnei/drug effects*

[Incidence of diarrhea and antibiotic therapy in cynomolgus monkeys imported for medical use (author's transl)]

Takasaka M, Morota S, Kasono T, Abe M, Honjo S

Jikken Dobutsu, 1973 Jul;22(3):227-36.

PMID: 4204642

Matched MeSH terms: Shigella sonnei/isolation & purification

Multiple drug resistance and the presence of R factors in enteric pathogens

Sng EH, Lam S

Med J Malaya, 1971 Jun;25(4):301-4.

PMID: 4261307

Matched MeSH terms: Shigella sonnei/drug effects

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