Browse publications by year: 1988

  1. Yadav GC, Reavey PC
    J. Inherit. Metab. Dis., 1988;11(3):277-84.
    PMID: 3148069
    We present a summary of the results of quantitative amino acid analysis in 800 subjects over a three-year period in Al-Sabah Hospital, Kuwait. Thirty-five patients with aminoacidopathy were identified, all but two of whom were the offspring of first-degree consanguineous marriages: nine cases of phenylketonuria, one benign hyperphenylalaninaemia, seven non-ketotic hyperglycinaemia, five tyrosinaemia, five homocystinuria, four citrullinaemia, two cystinuria, one hyperprolinaemia, and one maple syrup urine disease. The clinical and biochemical findings in these cases are described.
    MeSH terms: Adolescent; Amino Acid Metabolism, Inborn Errors/metabolism*; Amino Acids/analysis; Child; Child, Preschool; Citrulline/blood; Cystinuria/metabolism; Female; Glycine/blood; Homocystinuria/metabolism; Humans; Infant; Infant, Newborn; Kuwait; Male; Maple Syrup Urine Disease/metabolism; Phenylalanine/blood; Phenylketonurias/metabolism; Proline/blood; Tyrosine/blood
  2. Issa AR, Yadav G, Teebi AS
    J. Inherit. Metab. Dis., 1988;11(3):306-7.
    PMID: 3148074
    MeSH terms: Amino Acids/blood; Cerebral Palsy/metabolism; Child; Child, Preschool; Citrulline/blood*; Citrulline/genetics; Female; Humans; Infant, Newborn; Male; Phenotype; Genetic Variation*
  3. Rajakumar MK
    Republished in: Family Medicine, Healthcare and Society: Essays by Dr M K Rajakumar. p47-52
    MeSH terms: Family Practice; Primary Health Care
  4. Gomez-Eichelmann MC, Holz G, Beach D, Simpson AM, Simpson L
    Mol. Biochem. Parasitol., 1988 Jan 15;27(2-3):143-58.
    PMID: 3344003
    Eight strains of a lizard Leishmania species, L. tarentolae, were compared with four other saurian species [L. hoogstrali, L. adleri, L. agamae and Leishmania sp. LizS], with L. major from man and with Trypanosoma platydactyli, a putative lizard trypanosome, in terms of kinetoplast DNA minicircle and maxicircle sequences and in terms of nuclear chromosome patterns on orthogonal gel electrophoresis. The L. tarentolae strains fell into two major groups, one (group A) consisting of the L. tarentolae strains, UC, Krassner and Trager, derived from an Algerian gecko isolate and the other (group B) consisting of five L. tarentolae LEM strains isolated from geckos in southern France. T. platydactyli TPCL2, which was postulated by Wallbanks et al. to represent the lizard form of a French L. tarentolae strain, was closely related to the UC strain and not to the LEM strains, in all respects analyzed. Leishmania sp. LizS from a Mongolian gecko and L. hoogstrali from a Sudanese gecko showed some sequence similarities to the L. tarentolae strains, but the leishmanias said to be L. adleri from a Kenyan lacertid and L. agamae from an Israeli agamid showed no minicircle sequence similarities with lizard Leishmania and in fact were probably the same species. The maxicircle divergent region was larger in the group B strains than in the group A strains, but there were sequences in common with both groups, and not with L. hoogstrali and L. major. Four strains of L. tarentolae, the four other supposed saurian Leishmania species, three mammalian leishmanias, T. platydactyli and four other trypanosomes, T. cyclops (Malaysian macaque), T. conorrhini (Hawaiian reduviid bug), T. cruzi (man) and T. lewisi (feral rat) were analyzed for their contents of sterols and phosphoglyceride fatty acyl groups. T. platydactyli TPCL2 contained a sterol (5-dehydroepisterol), a phosphatidylcholine fatty acyl group (alpha-linolenic acid) and a phosphatidylethanolamine fatty acyl group (dihydrosterculic acid) characteristic of members of the genus Leishmania and not the genus Trypanosoma. The proportions of those lipids in the free sterol and phosphoglyceride fractions of T. platydactyli TPCL2 most closely resembled those seen in the Leishmania strains from Algerian, French, Mongolian and Sudanese geckos.
    MeSH terms: Animals; DNA, Circular/analysis; Leishmania/classification; Leishmania/isolation & purification*; Lizards/parasitology*; Membrane Lipids/analysis; Species Specificity
  5. Siar CH, Ng KH, Chia TY, Kulkarni MG
    Singapore Med J, 1988 Feb;29(1):83-5.
    PMID: 3406779
    The aetiology, clinical and histological features of neurilemmomas of the oral and paraoral regions are briefly outlined. Two cases of atypical neurilemmomas of the tongue are described with an intent to document the partial encapsulation and multilobular distribution of the neurogenic tissue noted in these two lesions.
    MeSH terms: Adolescent; China/ethnology; Female; Humans; Malaysia; Neurilemmoma/pathology; Tongue Neoplasms/pathology
  6. V K Khanijow VK, Raman R
    Singapore Med J, 1988 Feb;29(1):76-7.
    PMID: 3406777
    MeSH terms: Acute Disease; Adult; Bed Rest; Female; Glucocorticoids/therapeutic use; Hearing Loss, Sensorineural*; Hospitals, University; Humans; Male; Vasodilator Agents
  7. Roseman M
    Soc Sci Med, 1988;27(8):811-8.
    PMID: 2465577 DOI: 10.1016/0277-9536(88)90233-X
    Indigenous healers in many societies use patterned sounds, movements, colors, shapes, and odors as therapeutic techniques; yet medical anthropology remains curiously inattentive to the aesthetics of healing rituals. Based on research among Senoi Temiar of Peninsular Malaysia, I propose an approach to the therapeutic efficacy of these symbolic forms. The music of Temiar healing ceremonies is examined from three perspectives: the formal musical structures, the indigenous theories that inform those structures, and the strategies through which they are performed and experienced by participants. Temiar healing performances present a moment of articulation between two domains of knowledge and action: musical composition, performance, and affect, on the one hand, and indigenous cosmology, illness etiology, and the pathogenicity of emotions, on the other. Songs of Temiar spirit-mediums cross-cut these two domains, and demonstrate the pragmatics of aesthetics.
    MeSH terms: Cross-Cultural Comparison*; Esthetics*; Humans; Magic; Malaysia; Medicine, Traditional; Mental Healing*; Music; Sick Role; Symbolism
  8. Blok J, Kay BH, Hall RA, Gorman BM
    Arch. Virol., 1988;100(3-4):213-20.
    PMID: 2840873
    Thirteen strains of dengue type 1 were isolated from the lymphocyte fractions of 69 acute phase blood samples collected at Thursday Island Hospital during 1981 and 1982. One further strain of type 1 was isolated from 7 blood samples despatched by air from Cairns Base Hospital during 1982. Four of these Australian isolates representing the beginning, middle, and end of the epidemic were examined by restriction enzyme mapping and were found to be identical for the nine restriction enzymes used. The maps differed from those derived from two Malaysian dengue type 1 strains isolated during the epidemic of 1981-82 in that country. This suggests reliance on serological typing to establish global circulation patterns of epidemic dengue is insufficient and that more specific methods such as genome mapping are useful.
    MeSH terms: Adolescent; Adult; Child; Dengue/microbiology*; Dengue/epidemiology; Dengue Virus/classification; Dengue Virus/genetics; Dengue Virus/isolation & purification*; Disease Outbreaks*; DNA Restriction Enzymes; Female; Humans; Infant; Lymphocytes/microbiology; Malaysia; Male; Nucleic Acid Hybridization; Queensland; RNA, Viral/analysis; RNA, Viral/genetics; Serotyping
  9. Tan NH, Tan CS
    Comp. Biochem. Physiol., B, 1988;90(4):745-50.
    PMID: 2854766
    1. The L-amino acid oxidase, hyaluronidase, alkaline phosphomonoesterase, protease, phosphodiesterase, acetylcholinesterase, phospholipase A and 5'-nucleotidase activities of 47 samples of venoms from all the six species of cobra (Naja), including five subspecies of Naja naja, were examined. 2. The results demonstrated interspecific differences in the venom contents of phospholipase A, acetylcholinesterase, hyaluronidase and phosphodiesterase. These differences in venom enzyme contents can be used for the differentiation of species of the genus Naja. 3. Thus, our results revealed a correlation between the enzyme composition of venom and the taxonomic status of the snake at the species level for the genus Naja.
    MeSH terms: Acetylcholinesterase/analysis; Amino Acid Oxidoreductases/analysis; Animals; Cobra Venoms/analysis*; Enzymes/analysis*; Hyaluronoglucosaminidase/analysis; Nucleotidases/analysis; Peptide Hydrolases/analysis; Phosphoric Diester Hydrolases/analysis; Phospholipases A/analysis; Phosphoric Monoester Hydrolases/analysis; Snakes; Species Specificity; 5'-Nucleotidase; L-Amino Acid Oxidase
  10. Barker RA, Maxwell PH, Hong CP, Cordery MC, Chrystie IL
    Trans. R. Soc. Trop. Med. Hyg., 1988;82(6):898-901.
    PMID: 2855768
    Over a period of 2 months, 35 of 69 (51%) cases of juvenile diarrhoea studied in eastern Malaysia were associated with rotavirus excretion; rotavirus associated diarrhoea occurred most commonly in the 6-24 month age group. Polyacrylamide gel electrophoresis (PAGE) of genome ribonucleic acid showed that only 4 rotavirus electropherotypes could be detected. Of those, 2 predominated and 2 were detected only once each; one of these may have been a reassortment of the two predominant electropherotypes. Analysis of the clinical features of patients excreting rotavirus subgroup 1 or 2, determined by PAGE, demonstrated that rotavirus subgroup 1 was associated with more hypotonic dehydration and need for intravenous therapy: lethargy was significantly more common among those excreting rotavirus subgroup 2.
    MeSH terms: Child, Preschool; Dehydration/complications; Diarrhea/microbiology; Diarrhea/epidemiology*; Diarrhea, Infantile/epidemiology; Electrophoresis, Polyacrylamide Gel; Feces/microbiology; Female; Humans; Infant; Malaysia; Male; Rotavirus Infections/complications; Rotavirus/isolation & purification
  11. Chang MS, Jute N, Lah J
    Med. Vet. Entomol., 1988 Jan;2(1):19-28.
    PMID: 2908782
    Studies on larval population densities and adult emergence rates of the Brugian filariasis vectors Mansonia bonneae Edwards and Ma. dives Schiner were conducted in freshwater swamp forest bordering the Sadong River, Serian District, Sarawak, East Malaysia, during 1984-85. Three species of aquatic host-plants in the Family Araceae were identified as supporting immature stages of the Ma. bonneae/dives complex. Proportions of positive plants were 4.7%, 6.5% and 3.4% with 6.4 +/- 2.6, 7.3 +/- 2.8 and 10.1 +/- 1.1 larvae per positive plant, respectively, for the plant species Homalomena cordata Schott, H. rostrata Griffiths and Hydrostemma motleyi (Hook. f.) Mabberley. These data indicate no significant preferences between the three types of host-plant. Detailed monitoring of the host-plant H. cordata revealed no significant monthly fluctuations in larval density per plant nor the proportion of positive plants. 11.6% of larvae were Ma. dives and 88.4% were Ma. bonneae. Mean daily yields of Ma. bonneae/dives adults per square metre of H. cordata vegetated water surface were 0.45 males plus 0.57 females during the wet season (December-February) compared with 0.2 males plus 0.31 females during the dry season (June-August). Thus output of adults per plant was approximately halved, and suitable breeding areas were further reduced, during the dry season. By extrapolation from these rates, a crude mean estimate for productivity of Ma. bonneae/dives females is 1.6 million per hectare per annum in swamp forest habitats vegetated with any of the host-plants studied.
    MeSH terms: Animals; Brugia/physiology*; Elephantiasis, Filarial/transmission*; Female; Insect Vectors/growth & development*; Larva/growth & development; Malaysia; Male; Culicidae/growth & development*; Plants
  12. Sulaiman S, Sohadi AR, Yunus H, Iberahim R
    Med. Vet. Entomol., 1988 Jan;2(1):1-6.
    PMID: 2980156
    The role of some adult flies (Diptera: Cyclorrhapha) as carriers of helminth parasites of man was studied at four sites in Malaysia: a refuse dump, where no helminth-positive flies were detected, and in three peri-domestic situations where four species of flies carried up to three types of nematodes. The dominant fly species Chrysomya megacephala (Fabricius) carried eggs of the roundworm Ascaris lumbricoides L., the pinworm Trichuris trichiura (L.) and hookworm on the adult external body surface and in the gut lumen, in association with Bukit Lanjan aborigines. Chrysomya rufifacies (Macquart) and Sarcophaga spp. also had Ascaris lumbricoides and Trichurus trichiura eggs in their gut contents. Human helminths were not recovered from Lispe leucospila (Wiedemann), Lucilia cuprina (Wiedemann) or the housefly Musca domestica L. In an urban slum area of Kuala Lumpur city, filariform larvae identified as the hookworm Necator americanus (Stiles) occurred in the intestines of the face-fly Musca sorbens Wiedemann (22 larvae per 100 flies) and of Chrysomya megacephala (4.5 larvae per 100 flies). This concentration of apparently infective N. americanus in M. sorbens, a fly which often breeds in faeces and browses on human skin, could have transmission potential.
    MeSH terms: Animals; Diptera/parasitology*; Female; Helminthiasis/transmission*; Helminths/isolation & purification*; Humans; Insect Vectors/parasitology*; Malaysia; Male
  13. Segasothy M, Suleiman AB, Puvaneswary M, Rohana A
    Nephron, 1988;50(1):50-4.
    PMID: 3050572
    180 patients with end-stage renal disease (ESRD) on maintenance dialysis and those who had undergone renal transplantation were questioned retrospectively. 14 patients had consumed excessive quantities of analgesics (greater than 1 kg) prior to the institution of long-term dialysis or transplantation. Sonographic examination done on these patients indicated that 7 had renal papillary necrosis (RPN). The sonographic features were renal papillary calcifications surrounding the central sinus in a complete or incomplete garland pattern. In 5 of these patients RPN is attibutable to the excessive consumption of paracetamol. We have earlier reported 10 cases of RPN due to excessive consumption of paracetamol. Thus 15 cases of RPN attributable to paracetamol consumption (1.0-15.3 kg over a period ranging from 3 to 23 years) have been documented. It is concluded that paracetamol may assume an increasingly important role in the causation of analgesic nephropathy (AN) and ESRD.
    MeSH terms: Acetaminophen/adverse effects*; Adult; Aged; Calcinosis/chemically induced; Calcinosis/diagnosis; Female; Renal Dialysis; Humans; Kidney Diseases/chemically induced*; Kidney Diseases/diagnosis; Kidney Failure, Chronic/chemically induced*; Kidney Failure, Chronic/therapy; Male; Middle Aged; Retrospective Studies; Ultrasonography
  14. Thajunnisa bte Hassan Mohd, Yip CH
    Pediatr Radiol, 1988;18(5):406.
    PMID: 3050845
    Neuroblastoma is the most common malignant tumour in infancy originating in about 70% of cases in the adrenal gland. Haemorrhage and necrosis is often seen in neuroblastoma but cyst formation is uncommon. Fistulous communication between an adrenal cystic neuroblastoma and the large bowel has never to our knowledge been reported before.
    MeSH terms: Adrenal Gland Neoplasms/complications*; Adrenal Gland Neoplasms/diagnosis; Colonic Diseases/complications*; Colonic Diseases/diagnosis; Cysts/complications*; Cysts/diagnosis; Humans; Infant; Intestinal Fistula/complications*; Intestinal Fistula/diagnosis; Male; Neuroblastoma/complications*; Neuroblastoma/diagnosis; Tomography, X-Ray Computed; Ultrasonography
  15. Bahaman AR, Ibrahim AL
    Vet. Res. Commun., 1988;12(2-3):179-89.
    PMID: 3055663
    This paper reviews the literature on leptospirosis in Malaysia from its first description in 1928 until the present day. Most of the early reports were on investigations of leptospirosis in wildlife and man and up-to-date, thirty-seven leptospiral serovars from thirteen serogroups have been bacteriologically identified. The thirteen serogroups are: Australis, Autumnalis Bataviae, Canicola, Celledoni, Grippotyphosa, Hebdomadis, Icterohaemorrhagiae, Javanica, Pomona, Pyrogenes, Sejroe and Tarassovi. Rats have been ascribed as the principal maintenance host of leptospires in Malaysia. However, serovars from the Pomona, Pyrogenes and Sejroe serogroups have yet to be isolated from rats. It is considered that the majority of leptospirosis cases in man were due to association of man with an environment where rats were plentiful. Recent investigations on domestic animals disclosed a high prevalence of infection in cattle and pigs and they were suspected as being the maintenance host for serovar hardjo and pomona respectively. There is ample scope for research in leptospirosis, particularly in the epidemiology and control of the disease in domestic animals. The strategy to control the infection in domestic animals and man in Malaysia is bound to be different from that of the temperate countries, basically due to the presence of a large number of leptospiral serovars in wildlife, further confounded by geographical and financial constraints.
    MeSH terms: Animals; Animals, Domestic/microbiology*; Animals, Wild/microbiology*; Humans; Leptospira/classification; Leptospira/isolation & purification; Leptospirosis/epidemiology*; Leptospirosis/veterinary; Malaysia; Soil Microbiology; Water Microbiology
  16. Lewis GE, Miller LH, Ibrahim L, Wong PW, McGinniss M, Ooi WL
    Trans. R. Soc. Trop. Med. Hyg., 1988;82(3):509-10.
    PMID: 3068862
    Duffy phenotypes were determined for 314 Malaysian Orang Asli. The most common gene, Fya, was present in 313; there were no Duffy negative individuals. A previous study found evidence of Plasmodium vivax infection in 5 of 7 Orang Asli reported to be of the Duffy negative genotype. In this study, 5 of the 7 previously tested Orang Asli were retested in triplicate, and each of the 5 was found to be Duffy positive, having the Fya gene and a phenotype of Fy (a + b-).
    MeSH terms: Animals; Blood Group Antigens*; Duffy Blood-Group System*; Humans; Malaria/blood*; Malaysia; Phenotype; Plasmodium vivax
  17. Kan SP
    Public Health Rev, 1988;16(1-2):127-47.
    PMID: 3073434
    MeSH terms: Adolescent; Animals; Child; Child, Preschool; Female; Helminthiasis/epidemiology*; Helminthiasis/prevention & control; Helminthiasis/transmission; Humans; Intestinal Diseases, Parasitic/epidemiology*; Intestinal Diseases, Parasitic/prevention & control; Intestinal Diseases, Parasitic/transmission; Malaysia; Male; Public Health*; Socioeconomic Factors; Soil
  18. Joishy SK, Hassan K, Lopes M, Lie-Injo LE
    PMID: 3076706
    Clinical studies were carried out on mild Indian sickle cell anaemia in Malaysia, and genetic and fertility studies were carried out on 101 families with and without sickle-cell haemoglobin (Hb S). The Indian sickle cell anaemia patients reached adulthood, and pregnancies and deliveries were uneventful without blood transfusion. There was no foetal wastage and the number of children produced was not significantly different from that in families without Hb S. 28 Indian patients hospitalized with Plasmodium falciparum malaria infection were also examined for their beta S genotype. P. falciparum malaria infection occurred much more frequently in individuals without Hb S than in Hb S carriers.
    MeSH terms: Adolescent; Adult; Anemia, Sickle Cell/genetics; Animals; Bilirubin/blood; Child; Child, Preschool; Physical Exertion; Female; Fertility; Genotype; Globins/genetics*; Hemoglobin, Sickle/analysis*; Humans; India/ethnology; Infant; Kidney Concentrating Ability; Malaria/blood; Malaria/genetics*; Malaysia; Male; Middle Aged; Plasmodium falciparum
  19. Rajakumar MK, Ngeow YF, Khor BS, Lim KF
    Sex Transm Dis, 1988;15(1):25-6.
    PMID: 3162781
    Forty-three patients with uncomplicated gonorrhea were treated with 400 mg of ofloxacin. All had cultures negative for Neisseria gonorrhoeae at follow-up within two weeks of treatment. Minimal side effects were reported. Ofloxacin appears to be satisfactory as a single-dose oral drug for the treatment of gonococcal urethritis, including those cases caused by penicillinase-producing strains of N. gonorrhoeae.
    MeSH terms: Administration, Oral; Adult; Ambulatory Care Facilities; Anti-Infective Agents/therapeutic use*; Female; Gonorrhea/drug therapy*; Humans; Malaysia; Male; Middle Aged; Oxazines/administration & dosage; Oxazines/therapeutic use*; Private Practice; Ofloxacin; Clinical Trial
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