Browse publications by year: 2005

  1. Hazreen AM, Myint Myint S, Farizah H, Abd Rashid M, Chai CC, Dymna VK, et al.
    Med J Malaysia, 2005 Jun;60(2):180-7.
    PMID: 16114158
    To assess the level of knowledge, attitude and practice (KAP) on SARS and its preventive measures among the rural population of Kuala Kangsar district. This KAP study was also done to identify the expectation and preference of rural population upon obtaining health information. This is a cross-sectional study of 201 households from four villages in Kuala Kangsar. Face-to-face interview was done regarding knowledge, attitude and practice on SARS and its preventive measures. Statistical analyses were performed with SPSS (Version 10.0). A scoring system was used to assess the level of knowledge, attitude and practice towards SARS. Ninety one percent of the study population was aware of SARS. Majority of them have good attitude towards SARS based on the formulated scoring system. Television was found to be the first hand information about SARS and most preferred source of information by the rural population. Knowledge and attitude of respondents concerning SARS were good. Television was found to be the preference among the rural population in obtaining health information.
    MeSH terms: Adult; Cross-Sectional Studies; Disease Outbreaks/statistics & numerical data*; Female; Humans; Malaysia/epidemiology; Male; Middle Aged; Retrospective Studies; Rural Population*; Information Dissemination*; Severe Acute Respiratory Syndrome/epidemiology*
  2. Loh KY, Khairani O, Norlaili T
    Med J Malaysia, 2005 Jun;60(2):188-93.
    PMID: 16114159
    The aim of this study was to determine the prevalence of functional impairment and its associated factors among patients aged 60 years and above attending Klinik Kesihatan Batu 9 Ulu Langat, Selangor. This is a cross sectional community health clinic based study. A total of 260 elderly patients attending the community health clinic were interviewed. They were clinically assessed for functional impairment by using the 9 item Instrumental Activities of Daily Living (IADL) scale. There were 118 (45.4%) elderly male and 142 (54.6%) elderly female with age ranging from 60 years to 92 years with the mean age of 67.5 and 65.5 years for male and female respectively. Chinese form the largest population (42.3%) followed by Malay (36.5%), Indian (19.2%) and others (2.0%). The overall prevalence of functional impairment among elderly aged 60 years and above in this study was 33.5%. Among the functionally impaired, two patients (0.8%) were totally dependent. There were significant associations between functional impairment and older age (p = 0.025), lower income group (p = 0.010), lower education level (p = 0.030) and history of chronic medical illness (p = 0.020). Functional impairment had no significant association with ethnic group, gender, occupation and living arrangement. For daily activities that were assessed, the commonest impairment was inability to perform shopping (40%) followed by impairment in climbing up staircase (36.6%) and impairment in taking medication (35%). Advanced age, lower income, lower education and history of medical illness are associated with functional impairment. Functional impairment is an important consideration in caring for the elderly patients in the community. These findings have implications in caring of the elderly in which attention need to be paid to activities such as shopping, climbing stairs and taking medication. The use of the IADL scale is feasible for screening of functional impairment among the elderly population in the community.
    MeSH terms: Activities of Daily Living*; Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; China/ethnology; Cross-Sectional Studies; Disability Evaluation*; Female; Humans; India/ethnology; Malaysia; Malaysia/ethnology; Malaysia/epidemiology; Male; Middle Aged; Patient Compliance/statistics & numerical data*; Primary Health Care/statistics & numerical data*; Retrospective Studies; Geriatric Assessment/statistics & numerical data*; Prevalence; Frail Elderly*
  3. Wan Ishlah L, Gendeh BS
    Med J Malaysia, 2005 Jun;60(2):194-200.
    PMID: 16114160 MyJurnal
    Allergic rhinitis is the single most common chronic allergic disease affecting an estimated four million people in Malaysia. House dust mites, grass pollens and fungal spores play has been identified to play a major role in the pathogenesis of allergic rhinitis. However, sensitization to pollen and spores in Malaysia is not well documented. On the basis of the results of an aerobiological survey of the common mold spores and pollens in the Klang Valley, twelve local extracts of molds and two local extracts of grass pollens were prepared by the Institute for Medical Research for this study. The study evaluated the prevalence of skin prick test (SPT) reactivity to the extracts of those airborne molds and pollens in allergic rhinitis patients in the Klang Valley. A total of 85 allergic rhinitis patients were recruited. All molds and grass pollens extracts tested, elicited positive response to SPT. Among the molds extracts, Fusarium was observed to have the highest prevalence of SPT reactivity (23.5%), followed by Aspergillus flavum (21.2%), Dreselera orysae (18.8%), Alternaria sp (17.6%), Curvularis eragrostidis (17.6%), Penicillium oxa (16.5%), Pestolotriopsis gtuepini (16.5%), Rhizopphus arrhi (16.5%), Aspergilluls nigus (15.3%). Penicillium choy (12.9%), Aspergillus fumigatus (11.8%), and Cladosporium sp (4.7%). In the grass pollen, the SPT reactivity to Ischaemum and Enilia is 14.1% and 5.9% respectively. However, the prevalence of SPT reactivity was not influenced by the age, sex, ethnicity, symptomatology and concurrent allergic condition. We have documented the prevalence of skin prick test reactivity to common molds and grass pollens in the Klang valley, which is comparable to the neighboring countries. Its prevalence in our allergic rhinitis patients suggests that it has a role in pathogenesis of allergic diseases. A larger representative sample involving multi-centric centers in Malaysia should be encouraged in the near future.

    Study site: ENT
    Department, Pusat Perubatan University Kebangsaan Malaysia
    (PPUKM)
    MeSH terms: Adult; Environmental Exposure/adverse effects; Female; Fungi/immunology*; Hospitals, University; Humans; Malaysia; Malaysia/epidemiology; Male; Middle Aged; Outpatient Clinics, Hospital; Pollen/immunology*; Prospective Studies; Rhinitis, Allergic, Perennial/diagnosis*; Rhinitis, Allergic, Perennial/epidemiology; Skin Tests/methods*; Reproducibility of Results; Prevalence; Clinical Trial
  4. Ramesh G, Khamizar W
    Med J Malaysia, 2005 Jun;60(2):201-3.
    PMID: 16114161
    The use of high voltage radiotheraphy in pelvi malignancies has led to a common complication which is radiation . proctitis. Treatment with rectal formalin is simple and effective and can be done as a day care procedure. The use of formalin dab was assessed as a day care procedure in our surgical unit in which ten patients were prospectively evaluated. Outcome of these patients was encouraging.
    MeSH terms: Disinfectants/administration & dosage; Disinfectants/therapeutic use*; Female; Follow-Up Studies; Formaldehyde/administration & dosage; Formaldehyde/therapeutic use*; Humans; Instillation, Drug; Middle Aged; Proctitis/drug therapy*; Proctitis/etiology; Radiation Injuries/complications; Radiation Injuries/drug therapy*; Rectum; Retrospective Studies; Uterine Neoplasms/radiotherapy; Treatment Outcome
  5. Sudha V, Bairy KL, Shashikiran U, Sachidananda A, Jayaprakash B, Shalini S
    Med J Malaysia, 2005 Jun;60(2):204-11.
    PMID: 16114162
    OBJECTIVE AND STUDY DESIGN: A nonrandomized open labeled clinical trial to evaluate the efficacy and tolerability of Dianex (a poly herbal formulation developed by Apex Laboratories [PVT] Chennai, Tamil Nadu, India) in type 2 diabetes mellitus was carried out during a 6-month period.
    SETTING/LOCATION: This study was conducted in TMA Pai Hospital, Udupi, South India.
    SUBJECTS: A total of 40 patients were recruited for this study. Three patients dropped out of the study leaving a total of 37 patients (11 for monotherapy and 26 for add on therapy).
    OUTCOME MEASURES: Eighteen (18) clinical variables were investigated, including liver enzymes, kidney function tests, hematologic parameters, blood glucose, and insulin and lipid profiles.
    RESULTS: at the end of 12 weeks it was found that there was a significant decrease in the level of glycated hemoglobin, fasting plasma insulin level, insulin resistance, and systolic and diastolic blood pressure. At the end of 24 weeks results were similar to those at 12 weeks. Dianex did not alter the liver function tests, hematological parameters, or kidney function tests.
    CONCLUSION: In this preliminary study, Dainex is found to be an effective adjuvant drug with either oral antidiabetic agents or insulin that can be used in the control of blood sugars in diabetic patients. Dianex is a safe drug that does not cause any clinical, hematological or biochemical alteration in major organ systems.
    MeSH terms: Blood Glucose/metabolism; Diabetes Mellitus, Type 2/blood; Diabetes Mellitus, Type 2/drug therapy*; Female; Follow-Up Studies; Hemoglobins, Abnormal/metabolism; Hospitals; Humans; India; Male; Middle Aged; Plant Extracts/therapeutic use*; Safety; Clinical Trial; Treatment Outcome
  6. Mafauzy M
    Med J Malaysia, 2005 Jun;60(2):212-7.
    PMID: 16114163 MyJurnal
    This Diabcare-Asia project was initiated to study the status of diabetes care and prevalence of diabetic complications in Asia and this study was done to evaluate the above in primary private healthcare in Malaysia. A total of 49 private clinics participated in this study from which a total of 438 patients were included and analysed. The majority of patients (96.5%) had type 2 diabetes mellitus and 81.4% had BMI > or =23 kg/m2. Only 12.0% of the patients had their HbA1c measured in the preceding 12 months. As for glycaemic control only 20% of the patients had HbA1c <7% and 11% had FPG < 6.7 mmol/L. As for lipid levels, only 12.3% of the patients had total cholesterol < 4.8 mmol/L; 30.9% had HDL-cholesterol > 1.2 mmol/L and 49.8% had triglycerides < 1.7 mmol/L. Despite the high proportion of patients having dyslipidaemia. only 12.4% of the patients were on lipid lowering therapy. As for blood pressure, 55.9% of the patients had systolic pressure > or =140 mmHg and 40.9% had diastolic pressure > or =90 mmHg. However, only 32.4% of the patients were on antihypertensive medication. Only 37.4% of the patients admitted to adhering to diabetic diet regularly and 32.0% exercised regularly. As for glucose monitoring only 6.9% of the patients did home blood glucose monitoring and 6.2% did home urine glucose. There was also a high complication rate with the commonest being neuropathy (30.1%) followed by background retinopthy (23.5%), albuminuria (22.9%) and microalbuminuria (20.4%). In conclusion, the majority of diabetic patients treated at the primary care level were not satisfactorily controlled and this was associated with a high prevalence of complications. There is an urgent need to educate both patients and health care personnel on the importance of achieving the clinical targets and greater effort must be made to achieve these targets.
    MeSH terms: Ambulatory Care Facilities; Cross-Sectional Studies; Diabetes Mellitus/diagnosis*; Female; Follow-Up Studies; Humans; Malaysia; Male; Medical Audit; Middle Aged; Primary Health Care/methods*; Private Practice; Private Practice*; Urban Population; Diabetes Complications/diagnosis; Diabetes Complications/prevention & control
  7. Merican AM, Kwan MK, Cheok CY, Wong ELW, Sara TA
    Med J Malaysia, 2005 Jun;60(2):218-21.
    PMID: 16114164
    Near total amputation of the upper limb if unsalvageable would cause severe disability. However, delayed revascularisation can be life threatening. We report two cases of revascularisation of the upper limb following near total amputation that was successful and functional after a warm ischaemic time of ten hours. The first was a traction avulsion injury of the arm leaving major nerves contused but in continuity. The second was a sharp injury through the mid-forearm attached by only a bridge of skin. Attempting revascularisation of a proximal injury beyond 6 hours, in selected cases is worthwhile.
    MeSH terms: Adult; Amputation, Traumatic/surgery*; Arm/blood supply*; Arm Injuries/surgery*; Humans; Ischemia/surgery*; Male; Reoperation; Replantation/methods*; Time Factors; Limb Salvage*
  8. Hooi LN
    Med J Malaysia, 2005 Jun;60(2):222-5.
    PMID: 16114165
    Bronchiolitis obliterans organising peumonia BOO) is an uncommon inflammatory lung condition involving the terminal bronchioles and alveoli, which is responsive to treatment with corticosteroids. Patients usually present with dyspnoea, cough and fever. Two cases are described here; both had haemoptysis and were initially treated as community acquired pneumonia. Diagnosis was made on lung biopsy and there was rapid resolution after a course of prednisolone.
    MeSH terms: Adult; Aged; Biopsy; Bronchi/pathology; Bronchoscopy; Diagnosis, Differential; Female; Follow-Up Studies; Glucocorticoids/therapeutic use*; Humans; Male; Prednisolone/therapeutic use*; Tomography, X-Ray Computed; Cryptogenic Organizing Pneumonia/drug therapy*; Cryptogenic Organizing Pneumonia/pathology; Cryptogenic Organizing Pneumonia/radiography
  9. Thambidorai CR, Qureshi MA, Shukri J, Zulfiqar A
    Med J Malaysia, 2005 Jun;60(2):226-8.
    PMID: 16114166
    Posterior sagittal anorectoplasty (PSARP) is preferred by most pediatric surgeon and intermediate types of anorectal anomalies (ARA) in infants. In this report, we describe two girls who presented in their late teens with ARA and were treated by PSARP. Prior to this report, only two adult females with congenital rectovaginal fistulae treated by PSARP have been reported. Megarectum is a feature in late presentation of ARA and requires rectal tapering during PSARP. The functional outcome in late presentation of ARA is discussed.
    MeSH terms: Adolescent; Adult; Anal Canal/surgery*; Anus, Imperforate/diagnosis; Anus, Imperforate/surgery*; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Reconstructive Surgical Procedures/methods*
  10. Sudha V, Abhishek M, Shashikiran U, Annappa K, Mukhyaprana MP
    Med J Malaysia, 2005 Jun;60(2):229-31.
    PMID: 16114167
    Tropical pyomyositis is a primary pyogenic infection of skeletal muscle, often caused by Staphylococcus aureus. The most common presentation of tropical pyomyositis is that of multiple acute abscesses with fever. Hepatitis is a rare manifestation of this disease. We report a case of tropical pyomyositis who presented with hepatic encephalopathy leading to initial diagnostic dilemma.
    MeSH terms: Abscess/complications; Abscess/diagnosis*; Abscess/therapy; Anti-Bacterial Agents; Arm; Biopsy; Diagnosis, Differential; Drainage; Follow-Up Studies; Hepatic Encephalopathy/complications; Hepatic Encephalopathy/diagnosis; Humans; Leg; Liver/pathology; Liver/ultrasonography; Male; Middle Aged; Staphylococcal Infections/complications; Staphylococcal Infections/diagnosis; Staphylococcal Infections/therapy; Suppuration; Polymyositis/complications; Polymyositis/diagnosis*; Polymyositis/therapy; Muscle, Skeletal/pathology; Muscle, Skeletal/ultrasonography
  11. Hussein Z, Tress B, Colman PG
    Med J Malaysia, 2005 Jun;60(2):232-6.
    PMID: 16114168
    Thyrotoxicosis due to Graves disease is a relatively common endocrine disorder. The occurrence of a prolactinoma with co-secretion of growth hormone (GH) is on the other hand, rare. We report the rare co-existence of Graves' disease in a patient with macroprolactinoma and GH hypersecretion and describe the successful response to medical therapy with dopamine agonist and antithyroid therapy. We hypothesize that hyperprolactinaemia played a role in promoting autoimmune thyroid disease in our patient and that treatment of hyperprolactinaemia may have been important in suppressing autoimmune disease activity in Graves' disease. This case also reflects on the close and complex interactions between thyroid hormones, prolactin (PRL), GH and testosterone (T).
    MeSH terms: Adult; Case Reports; China/ethnology; Graves Disease/blood; Graves Disease/complications*; Graves Disease/drug therapy; Humans; Hyperthyroidism*; Malaysia; Male; Pituitary Neoplasms/blood; Pituitary Neoplasms/complications*; Pituitary Neoplasms/drug therapy; Prolactin/blood; Growth Hormone/blood; Growth Hormone/secretion*; Antithyroid Agents/therapeutic use; Thyroid Hormones/blood; Prolactinoma/blood; Prolactinoma/complications*; Prolactinoma/drug therapy; Biomarkers/blood; Dopamine Agonists/therapeutic use
  12. Kalyani A, Teoh CM, Sukumar N
    Med J Malaysia, 2005 Jun;60(2):237-8.
    PMID: 16114169
    A patient with duodenal ulcer who developed iatrogenic perforation post endoscopy is presente. We present t is case that was treated successfully treated by jejunal serosal patch.
    MeSH terms: Aged; Duodenal Ulcer/diagnosis; Duodenoscopy/adverse effects*; Duodenum/injuries*; Duodenum/surgery*; Female; Follow-Up Studies; Humans; Iatrogenic Disease*; Jejunum/transplantation*; Laparotomy/methods*; Peptic Ulcer Hemorrhage/diagnosis; Rupture/surgery
  13. Yusoff K
    Med J Malaysia, 2005 Jun;60(2):239-45.
    PMID: 16114170
    ALLHAT study is the biggest randomized clinical trial in hypertension ever conducted. Its objective was to ompare the efficacy of newer (calcium channel blocker amlodipine and angiotensin-converting enzyme inhibitor inopril) to the older (diuretic chlorthalidone) antihypertensive agents in the treatment of patients with hypertension. After enrolling 42,000 patients who were followed for an average of 4.9 years, ALLHAT did not find significant differences in the primary end-points between these antihypertenive agents. ALLHAT however found significant differences in the secondary end-points such as heart failure and strokes between chlorthalidone and amlodipine or lisinopril. Based on these and on economic reasons, the investigators unequivocally recommended diuretics as the first line therapy for hypertension. Since its publication, ALLHAT has been much discussed, debated A and opined. The choice of drugs for study, the study design, the conduct of the study and the conclusions drawn by the investigators had all been criticised or controversial. Yet ALLHAT has been widely quoted, commented upon or referred to and it has been instrumental in initiating the JNC VII Guidelines. Thus a thorough understanding of ALLHAT is necessary for clinical practice and in designing and evaluating clinical trials in the future. Moving Points: in Medicine will capture the essence of ALLHAT, discusses its implications to clinical trials and explores its possible impact on the practice of medicine in this country.
    MeSH terms: Antihypertensive Agents/therapeutic use*; Hypolipidemic Agents/therapeutic use*; Clinical Trials as Topic; Heart Diseases/etiology; Heart Diseases/prevention & control*; Humans; Hypertension/complications; Hypertension/drug therapy*; Malaysia; Disease Management
  14. Chan YF, Abu Bakar S
    Med J Malaysia, 2005 Jun;60(2):246-8.
    PMID: 16114171
    The efficacy of Virkon S, a commercial disinfectant as a virucidal spray against human enterovirus 71 (HEV71), the causative agent of the fatal form of hand, foot and mouth disease was examined. At least one log10 reduction of HEV71 titer was achieved when one spray of Virkon (1% or 2%) with ten minutes of contact time was applied. The infectivity was completely lost when four sprays of 1% or 2% Virkon were applied, suggesting that at least four sprays of 1% Virkon to the surface bound HEV71 was necessary to completely inactivate the virus. These findings suggest that Virkon S at the proper concentration is suitable to be used as an effective and easy to use disinfectant against HEV71.
    MeSH terms: Administration, Topical; Disinfectants/administration & dosage; Disinfectants/therapeutic use*; Enterovirus Infections/drug therapy*; Enterovirus Infections/virology; Enterovirus/classification*; Enterovirus/drug effects*; Humans; Peroxides/administration & dosage; Peroxides/therapeutic use*; Sulfuric Acids/administration & dosage; Sulfuric Acids/therapeutic use*; Treatment Outcome
  15. Liam CK
    Med J Malaysia, 2005 Jun;60(2):249-65; quiz 266.
    PMID: 16114172
    MeSH terms: Humans; Malaysia/epidemiology; Incidence; Survival Rate; Community-Acquired Infections/epidemiology
  16. Lua PL, Salek S, Finlay I, Lloyd-Richards C
    Qual Life Res, 2005 Sep;14(7):1669-81.
    PMID: 16119179 DOI: 10.1007/s11136-005-2817-8
    In terminally-ill patients, effective measurement of health-related quality of life (HRQoL) needs to be done while imposing minimal burden. In an attempt to ensure that routine HRQoL assessment is simple but capable of eliciting adequate information, the McGill Quality of Life Questionnaire-Cardiff Short Form (MQOL-CSF: 8 items) was developed from its original version, the McGill Quality of Life Questionnaire (MQOL: 17 items). Psychometric properties of the MQOL-CSF were then tested in palliative care patients consisting of 55 out-patients, 48 hospice patients and 86 in-patients: The MQOL-CSF had little respondent burden (mean completion time = 3.3 min) and was evaluated as 'very clear' or 'clear' (98.2%), comprehensive (74.5%) and acceptable (96.4%). The internal consistency reliability was moderate to high (Cronbach's alpha = 0.462-0.858) and test-retest reliability (Spearman's r(s)) ranged from 0.512-0.861. Correlation was moderate to strong (0.478-0.725) between items in the short form and their analogous domains in the MQOL. Most MQOL-CSF items showed strong associations with their own domain (r(s) > or = 0.40). Scores from MQOL-CSF significantly differentiated between patients with differing haemoglobin levels (p < 0.05). Construct validity was overall supported by principal component analysis. It is concluded that the MQOL-CSF is a feasible tool with favourable psychometric properties for routine HRQoL assessment in the palliative care population.
    Study site: out-patient palliative care clinic; a hospice centre and hospital inpatient wards, United Kingdom
    MeSH terms: Adult; Aged; Aged, 80 and over; Feasibility Studies; Female; Great Britain; Hospitals; Humans; Male; Middle Aged; Outpatient Clinics, Hospital; Palliative Care*; Psychometrics/instrumentation*; Quality of Life*; Surveys and Questionnaires*; Wales; Reproducibility of Results; Hospice Care*; Sickness Impact Profile*
  17. Ng TP, Lim LC, Jin A, Shinfuku N
    Qual Life Res, 2005 Sep;14(7):1755-68.
    PMID: 16119186
    BACKGROUND: Health-related quality of life in adolescents and ethnic and cultural differences are not well characterized. We used the Quality of Life Questionnaire for Adolescents (QOLQA) to examine ethnic differences in reported QOL scores among Chinese, Malay and Indian ethnicities in Singapore.

    METHODS: The 70-item QOLQA measuring five QOL domains (physical, psychological, independence, social and environmental) was administered to a random sample of 1363 school-children aged 10-15 years, representative of the ethnic composition of Singapore adolescents (Chinese 72%, Malays 20% and Indians 8%).

    RESULTS: Indians reported the highest overall QOL (mean 3.71 +/- SD 0.54) compared to Chinese (3.59 +/- 0.43), p < 0.05, and Malays (3.58 +/- 0.44), p < 0.05. In particular, Indians had significantly higher psychological QOL scores (3.73 +/- 0.61) compared to Chinese (3.55 +/- 0.54), p < 0.01. On the other hand, Chinese scored highest on physical and independence domains (3.97 +/- 0.54), p < 0.01 compared to Malays (3.82 +/- 0.55). There were no statistically significant gender differences in QOL scores. QOL declined significantly from age 10 to 15 for overall score, psychological, physical (p < 0.01) and environmental (p < 0.05). Lower socio-economic status and the self-report of a significant health problem were significantly associated with lower overall QOL and most domains. These ethnic differences persisted after adjusting for differences in socio-economic and health status. Psychometric properties and known group construct validity appeared to be similar across different ethnic groups, but compared to Chinese (r = 0.39) or Malays (r = 0.39), Indians showed a higher correlation of psychological scores with physical score (r = 0.59) and with other domain scores.

    CONCLUSION: Significant ethnic differences in reported adolescent quality of life among Chinese, Malays and Indians in Singapore that are independent of socioeconomic and health status suggest important cultural differences.

    MeSH terms: Adolescent; Psychology, Adolescent*; Child; Child Welfare/ethnology*; China/ethnology; Cross-Cultural Comparison; Female; Humans; India/ethnology; Malaysia/ethnology; Male; Psychometrics*; Quality of Life/psychology*; Surveys and Questionnaires; Singapore/epidemiology; Asian Continental Ancestry Group
  18. Chan YF, AbuBakar S
    Virol J, 2005;2:74.
    PMID: 16122396
    At least three different EV-71 subgenotypes were identified from an outbreak in Malaysia in 1998. The subgenotypes C2 and B4 were associated with the severe and fatal infections, whereas the B3 virus was associated with mild to subclinical infections. The B3 virus genome sequences had >= 85% similarity at the 3' end to CV-A16. This offers opportunities to examine if there are characteristic similarities and differences in virulence between CV-A16, EV-71 B3 and EV-71 B4 and to determine if the presence of the CV-A16-liked genes in EV-71 B3 would also confer the virus with a CV-A16-liked neurovirulence in mice model infection.
    MeSH terms: Amino Acid Sequence; Animals; Animals, Newborn; Brain/virology; Disease Outbreaks; Enterovirus Infections/epidemiology; Enterovirus Infections/virology*; Genotype; Humans; Malaysia/epidemiology; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Viral/genetics; Virulence; Survival Analysis; Sequence Alignment; Sequence Homology; Sequence Analysis, DNA; Encephalitis, Viral/virology*; Enterovirus A, Human/classification; Enterovirus A, Human/isolation & purification*; Enterovirus A, Human/pathogenicity*; Mice
  19. Misbah S, Hassan H, Yusof MY, Hanifah YA, AbuBakar S
    Singapore Med J, 2005 Sep;46(9):461-4.
    PMID: 16123830
    This study aims to identify Acinetobacter of clinical isolates from the University of Malaya Medical Centre (UMMC), Kuala Lumpur, to the species level by 16S rDNA sequencing.
    MeSH terms: Base Sequence; DNA, Bacterial/genetics*; DNA, Ribosomal/genetics*; Genes, Bacterial/genetics*; Humans; RNA, Ribosomal, 16S/genetics*; Genome; Databases, Genetic; Acinetobacter baumannii/genetics*; Acinetobacter baumannii/isolation & purification
  20. Madhavan M, P JG, Abdullah Jafri J, Idris Z
    Acta Cytol., 2005 Jul-Aug;49(4):431-4.
    PMID: 16124175
    BACKGROUND: Squamous papillary craniopharyngioma is a distinct entity, and its cytologic features may be misleading. Because of the rarity of this tumor, this case is being reported with a note on the cytologic features.

    CASE: A 56-year-old Malay man who had 1-month history of generalized lethargy was admitted for altered sensorium. On examination, he was found to have neck stiffness, bilateral papilledema and generalized atrophy of muscles, with reduced power in all limbs. Magnetic resonance imaging of the brain showed a solid mass in the third ventricle causing obstructive hydrocephalus. Intraoperative cytology of the mass diagnosed intraventricular meningioma. However, the final histopathologic examination revealed squamous papillary craniopharyngioma.

    CONCLUSION: Craniopharyngioma, squamous papillary type, is a rare entity and usually occurs in adults as an intraventricular solid tumor. Awareness of this entity will aid in arriving at the correct cytologic diagnosis.
    MeSH terms: Cell Nucleus/pathology; Craniopharyngioma/diagnosis*; Craniopharyngioma/pathology; Humans; Magnetic Resonance Imaging; Male; Meningeal Neoplasms/diagnosis*; Meningioma/diagnosis*; Middle Aged; Pituitary Neoplasms/diagnosis*; Pituitary Neoplasms/pathology; Fatal Outcome; Third Ventricle/pathology*
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