Browse publications by year: 2012

  1. Das S, Rajalingham S
    Pain, 2012 Jan;153(1):250-251.
    PMID: 22119339 DOI: 10.1016/j.pain.2011.10.039
    MeSH terms: Contraceptives, Oral, Hormonal/administration & dosage*; Female; Humans; Pain/blood*; Pain/drug therapy*; Pain Measurement/drug effects*; Temporomandibular Joint Disorders/blood*; Temporomandibular Joint Disorders/drug therapy*; Drug Delivery Systems/methods*
  2. Mohd Nawawi H, Abdul Rahman T, Mohd Ismail A, Ismail TS, Ramli AS, Yusoff K, et al.
    J Hypertens, 2012;30:e196.
    DOI: 10.1097/01.hjh.0000420656.24296.e4
    Background: Coronary artery disease (CAD) is the leading cause of mortality globally, primarily attributed by atherosclerosis, of which dyslipidaemia is one of the main risk factors. There is limited data in Malaysia on the prevalence and awareness of having dyslipidaemia, and the proportion who are treated.
    Objectives: To investigate the prevalence of (1)dyslipidaemia; (2)awareness of dyslipidaemia and (3)subjects with dyslipidaemia who are treated.
    Methodology: This was a cross-sectional study involving 11,525 Malaysian subjects from various rural and urban populations, with representations from the three major ethnic groups (age mean + SD: 52.6 + 11.3years; 6487 females, 5038 males). Clinical history and physical examinations were performed and fasting blood samples were collected for the measurement of lipid profiles. Dyslipidaemia was defined by mild, moderate or severe hypercholesterolaemia(HC):TC > 5.2, 6.5 and 7.8mmol/L respectively, or hypertriglyceridaemia (HTG):TG > 1.7 mmol/L, or low HDL-c:females < 1.3, males < 1.0mmol/L. Questionnaires were completed for data on awareness and treatment of dyslipidaemia.
    Results: Subjects with HC and HTG were 66.9% and 40.9% respectively. Low HDL-c were found in 15.2% and 74.9% in females and males respectively. Among those with HC, 42.6%, 19.3% and 5.0% had mild, moderate and severe HC respectively. Awareness of dyslipidaemia was only found in 13.9% of the population, of whom only 8.0% were on treatment.
    Conclusion: There is a high prevalence of dyslipidaemias in Malaysia, majority of whom are unaware of having the major risk factor for atherosclerosis-related complications such as CAD. Hence, there is an urgent need for coronary risk identification, prevention and intervention to combat the global epidemic of CAD
    MeSH terms: Adult; Cross-Sectional Studies; Ethnic Groups; Female; Humans; Hyperlipidemias; Malaysia; Male; Rural Population; Urban Population; Prevalence
  3. Zucchi TD, Tan GYA, Bonda ANV, Frank S, Kshetrimayum JD, Goodfellow M
    Int J Syst Evol Microbiol, 2012 Jun;62(Pt 6):1245-1251.
    PMID: 21764982 DOI: 10.1099/ijs.0.031039-0
    The taxonomic positions of three thermophilic actinomycetes isolated from arid soil samples were established by using a polyphasic approach. The organisms had chemical and morphological features that were consistent with their classification in the genus Amycolatopsis. 16S rRNA gene sequence data supported the classification of the isolates in the genus Amycolatopsis and showed that they formed distinct branches in the Amycolatopsis methanolica subclade. DNA-DNA relatedness studies between the isolates and their phylogenetic neighbours showed that they belonged to distinct genomic species. The three isolates were readily distinguished from one another and from the type strains of species classified in the A. methanolica subclade based on a combination of phenotypic properties and by genomic fingerprinting. Consequently, it is proposed that the three isolates be classified in the genus Amycolatopsis as representatives of Amycolatopsis granulosa sp. nov. (type strain GY307(T) = NCIMB 14709(T) = NRRL B-24844(T)), Amycolatopsis ruanii sp. nov. (type strain NMG112(T) = NCIMB 14711(T) = NRRL B-24848(T)) and Amycolatopsis thermalba sp. nov. (type strain SF45(T) = NCIMB 14705(T) = NRRL B-24845(T)).
    MeSH terms: Actinomycetales/classification*; Actinomycetales/genetics; Actinomycetales/isolation & purification*; DNA, Bacterial/genetics; Molecular Sequence Data; Phylogeny; RNA, Ribosomal, 16S/genetics; Soil Microbiology*
  4. Zucchi TD, Tan GYA, Goodfellow M
    Int J Syst Evol Microbiol, 2012 Jan;62(Pt 1):168-172.
    PMID: 21378137 DOI: 10.1099/ijs.0.029256-0
    The taxonomic positions of two thermophilic actinomycetes isolated from an arid Australian soil sample were established based on an investigation using a polyphasic taxonomic approach. The organisms had chemical and morphological properties typical of members of the genus Amycolatopsis and formed distinct phyletic lines in the Amycolatopsis methanolica 16S rRNA subclade. The two organisms were distinguished from one another and from the type strains of related species of the genus Amycolatopsis using a range of phenotypic properties. Based on the combined genotypic and phenotypic data, it is proposed that the two isolates be classified in the genus Amycolatopsis as Amycolatopsis thermophila sp. nov. (type strain GY088(T)=NCIMB 14699(T)=NRRL B-24836(T)) and Amycolatopsis viridis sp. nov. (type strain GY115(T)=NCIMB 14700(T)=NRRL B-24837(T)).
    MeSH terms: Actinomycetales/classification*; Actinomycetales/genetics; Actinomycetales/isolation & purification*; Actinomycetales/physiology; Australia; DNA, Bacterial/genetics; DNA, Bacterial/chemistry; DNA, Ribosomal/genetics; DNA, Ribosomal/chemistry; Molecular Sequence Data; Phylogeny; RNA, Ribosomal, 16S/genetics; Soil Microbiology*; Bacterial Typing Techniques; Cluster Analysis; Sequence Analysis, DNA
  5. Kämpfer P, Lai WA, Arun AB, Young CC, Rekha PD, Martin K, et al.
    Int J Syst Evol Microbiol, 2012 Nov;62(Pt 11):2750-2756.
    PMID: 22286908 DOI: 10.1099/ijs.0.039057-0
    A Gram-negative, coccoid-shaped bacterium, strain CC-CCM15-8(T), was isolated from a rhizosphere soil sample of the plant Crossostephium chinense (L.) Makino (Seremban) from Budai Township, Chiayi County, Taiwan. 16S rRNA gene sequence analysis clearly allocated strain CC-CCM15-8(T) to the Paracoccus cluster, showing highest similarities to the type strains of 'Paracoccus beibuensis' (98.8%), Paracoccus homiensis (97.6%), Paracoccus aestuarii (97.7%) and Paracoccus zeaxanthinifaciens (97.7%). The fatty acid profile, comprising C(18:1)ω7c as the major component and C(10:0) 3-OH as the characteristic hydroxylated fatty acid, supported the placement of strain CC-CCM15-8(T) within the genus Paracoccus. The polyamine pattern consisted of putrescine and spermidine as major components. Ubiqinone Q-10 was the major quinone type (95%); ubiquinone Q-9 was also detected (5%). The complex polar lipid profile consisted of diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine, and unidentified phospholipids, lipids and glycolipids. Levels of DNA-DNA relatedness between strain CC-CCM15-8(T) and 'P. beibuensis' LMG 25871(T), P. aestuarii DSM 19484(T), P. zeaxanthinifaciens LMG 21993(T) and P. homiensis KACC 11518(T) were 24.9% (34.8%, reciprocal analysis), 15.7% (17.5%), 17.7% (23.4%) and 16.0% (25.4%), respectively. Physiological and biochemical test results allowed the phenotypic differentiation of strain CC-CCM15-8(T) from its closest relatives in the genus Paracoccus. Based on the data presented, it is concluded that strain CC-CCM15-8(T) represents a novel species of the genus Paracoccus, for which the name Paracoccus rhizosphaerae sp. nov. is proposed. The type strain is CC-CCM15-8(T) (=LMG 26205(T)=CCM 7904(T)).
    MeSH terms: DNA, Bacterial/genetics; Fatty Acids/analysis; Molecular Sequence Data; Paracoccus/classification*; Paracoccus/genetics; Paracoccus/isolation & purification; Phylogeny*; Polyamines/analysis; Quinones/analysis; RNA, Ribosomal, 16S/genetics; Soil Microbiology; Taiwan; Bacterial Typing Techniques; Sequence Analysis, DNA; Asteraceae/microbiology*; Rhizosphere*
  6. Ghaderi Z, Mat Som AP, Henderson JC
    Tour Manag Perspect, 2012 04 26;2:79-84.
    PMID: 32289006 DOI: 10.1016/j.tmp.2012.03.006
    Crisis management and tourism is attracting increasing attention as an industry practice and subject of academic enquiry, not least in South East Asia which has been affected by a number of severe crises in recent years. However, organisations are not always well prepared and response strategies can be deficient. The paper discusses issues of tourism crisis management with specific reference to the popular Malaysian destination of Penang. Findings are based on qualitative research consisting of semi-structured interviews with industry leaders from assorted sectors. Tourism in Penang emerges as vulnerable to regional and global events which act as a trigger for tourism crises, demanding a response in which various strategies are employed. The destination is also seen to recover fairly quickly from experiences of crises, but a well designed and formulated tourism crisis management plan under the stewardship of the public sector is necessary to mitigate further damage in the future.
  7. Zong Z, Wang X, Deng Y, Zhou T
    J. Med. Microbiol., 2012 Oct;61(Pt 10):1483-1484.
    PMID: 22820689 DOI: 10.1099/jmm.0.041525-0
    A previously healthy Chinese male returned from working in the Malaysian jungle with a fever. A blood culture grew Gram-negative bacilli that were initially identified as Burkholderia cepacia by the VITEK 2 system but were subsequently found to be Burkholderia pseudomallei by partial sequencing of the 16S rRNA gene. The identification of B. pseudomallei using commercially available automated systems is problematic and clinicians in non-endemic areas should be aware of the possibility of melioidosis in patients with a relevant travel history and blood cultures growing Burkholderia spp.
    MeSH terms: Adult; Bacteriological Techniques*; DNA, Bacterial/classification; DNA, Bacterial/genetics; Humans; Male; Melioidosis/diagnosis; Melioidosis/microbiology*; RNA, Bacterial/classification; RNA, Bacterial/genetics; RNA, Ribosomal, 16S/classification; RNA, Ribosomal, 16S/genetics; Sensitivity and Specificity; Burkholderia cepacia/classification*; Burkholderia pseudomallei/classification*; Burkholderia Infections/diagnosis; Burkholderia Infections/microbiology
  8. Neela V, Thomas R, Rankouhi SZR, Karunanidhi A, Shueh CS, Hamat RA, et al.
    J. Med. Microbiol., 2012 Dec;61(Pt 12):1792-1794.
    PMID: 22956752 DOI: 10.1099/jmm.0.049403-0
    MeSH terms: Bacteriological Techniques; Deoxyribonucleases/metabolism*; Humans; Sensitivity and Specificity; Gram-Negative Bacterial Infections/microbiology; Stenotrophomonas maltophilia/enzymology*; Enzyme Assays*
  9. Muttarak M, Sriburi T
    Biomed Imaging Interv J, 2012 Jan;8(1):e7.
    PMID: 22970063 DOI: 10.2349/biij.8.1.e7
    OBJECTIVE: To document the types of congenital renal anomalies detected in adulthood, the clinical presentation and complications of these renal anomalies, and the most useful imaging modality in detecting a renal anomaly.

    MATERIALS AND METHODS: This study was approved by the institutional review board and informed consent was waived. Between January 2007 and January 2011, the clinical data and imaging studies of 28 patients older than 18 years diagnosed with renal anomaly at the authors' institution were retrospectively reviewed. Renal anomalies in this study included only those with abnormality in position and in form.

    RESULTS: Of these 28 patients, 22 underwent imaging studies and their results constituted the material of this study. Of the 22 patients, 14 had horseshoe kidneys (HSK), four had crossed renal ectopia and four had malrotation. Sixteen patients were men and six were women. The patients ranged in age from 19 to 74 years (mean age 51.1 years). Clinical presentations were abdominal pain (13), fever (13), haematuria (4), palpable mass (2), asymptomatic (2), polyuria (1) dysuria (1), blurred vision (1), and headache with weakness of left extremities (1). Imaging studies included abdominal radiograph (15), intravenous pyelography (IVP) (8), retrograde pyelography (RP) (4), ultrasonography (US) (7), and computed tomography (CT) (9). Associated complications included urinary tract stones (17), urinary tract infection (16), hydronephrosis (12), and tumours (2). Abdominal radiograph suggested renal anomalies in nine out of 15 studies. IVP, RP, US and CT suggested anomalies in all patients who had these studies performed. However, CT was the best imaging modality to evaluate anatomy, function and complications of patients with renal anomalies.

    CONCLUSION: HSK was the most common renal anomaly, with abdominal pain and fever being the most common presentations. UTI and stones were the most common complications. IVP, RP, US and CT can be used to diagnose renal anomalies but CT is the best imaging modality to evaluate renal anatomy, function and its complications.

  10. Chin CC, Beauchamp A, Sellick K
    Background: Consistent with other countries, Malaysia suffers from a shortage of nursing faculty. In several studies it has been seen that job satisfaction has been shown to contribute to retention of nurse educators. The majority of these studies are from developed countries and were conducted over ten years ago. As a result these findings may not be relevant to contemporary Malaysia. So, the purpose of this study was to investigate the levels of job satisfaction among nurse lecturers in Malaysia.
    Methods: A total of 20 nursing colleges throughout Malaysia were selected for random sampling, of which 30% agreed to participate. The Minnesota Satisfaction Questionnaire with additional demographic and organizational characteristics questions was used to collect the data. Descriptive statistics was used to examine differences in job satisfaction between demographic and organizational variables. Spearman’s rho was used to test the relationship between each of the demographic / organizational characteristics and overall job satisfaction.
    Results: A total of 73 nurse lecturers (73% response rate) returned the completed questionnaire. The findings indicated only a moderate level of job satisfaction. There were no significant correlations between demographic or organizational variables and overall job satisfaction levels with the exception of the number of students (p = 0.017).
    Conclusions: An understanding of the factors affecting job satisfaction among nursing faculty could enhance retention and recruitment in this profession. Further research using a combination of quantitative and qualitative approaches is recommended to provide an in-depth understanding of nursing lecturers’ perceptions of job satisfaction.
    Keywords: Nurse Job Satisfaction, Nurse Lecturers, Nurse Job
    MeSH terms: Adult; Cross-Sectional Studies; Faculty; Humans; Job Satisfaction; Malaysia; Nurses
  11. Hussain NHN, Hamid HA, Kadir AA, Musa KI, Ismail SB
    Introduction: Metabolic syndrome (MetS) is a condition that includes the presence of a cluster of risk factors specific for cardiovascular disease (CVD). The criteria used to aid the diagnosis of MetS includes abdominal obesity, elevated triglycerides, low high density lipoprotein (HDL) cholesterol, hypertension or use of antihypertensive medication, elevated fasting blood glucose and other risk factors. Objective: This study aimed to determine the prevalence of metabolic syndrome (MetS) among postmenopausal women and its associated factors in a tertiary center in Malaysia Methods: This is a cross-sectional study done among 411 postmenopausal women attending Gynaecology clinic and Family Medicine clinic in a tertiary center in Malaysia. Socio demographic data, reproductive profile, menopausal profile and medical history were obtained. Then waist circumference (WC), weight, height and blood pressure (BP) were also recorded. A fasting blood sample was obtained for serum glucose and lipid profile determinations. Metabolic syndrome was defined according to the criteria of International Diabetes Federation. Results: The mean age of participants was 57.2 + 6.9 years. The prevalence of metabolic syndrome was 36.7%. The risk of MetS increased with the presence of obstetrics history of hypertension (HPT) (odds ratio (OR) 2.64, 95% (CI) 1.25-5.62), previous usage of contraception (odds ratio (OR) 1.56, 95% (CI) 1.02-2.42), family history of HPT (odds ratio (OR) 1.71, 95% (CI) 1.13-2.59) and obesity (odds ratio (OR) 2.59, 95% (CI) 1.08-6.23). Conclusion: There was a high prevalence of the metabolic syndrome in postmenopausal women seeking gynaecologic and primary health care in the tertiary center Malaysia. The associated factors of MetS include previous obstetrics history of HPT, family history of HPT and obesity.
    MeSH terms: Adult; Aged; Ambulatory Care Facilities; Body Height; Body Weight; Contraception; Cross-Sectional Studies; Female; Glucose; Humans; Hypertension; Malaysia; Menopause; Obesity; Postmenopause; Metabolic Syndrome X; Waist Circumference
  12. Ngeow WC
    J Neurosci Rural Pract, 2012 May;3(2):158.
    PMID: 22865968
  13. Abdulameer SA, Sulaiman SAS, Hassali MAA, Subramaniam K, Sahib MN
    Diabetology International, 2012;3:113-130.
    DOI: 10.1007/s13340-012-0083-x
    Introduction: Diabetes mellitus (DM) is a pandemic and heterogeneous metabolic disorder with significant morbidity and mortality. In addition, osteoporosis (OP) is a silent disease that constitutes an enormous socioeconomic crisis, with a harmful impact on morbidity and mortality. Therefore, this systematic review focuses on the association between OP and type 1 diabetes mellitus (T1DM). Methods: Systematic reviews of full-length articles published in English from January 1950 to October 2010 were identified in PubMed and other available electronic databases at Universiti Sains Malaysia Library Database. The following keywords were used for the search: T1DM, insulin, OP, bone mass, and skeletal. Studies of more than 20 patients with T1DM were included. Results: Fifty studies were identified. In general, most of the studies showed unambiguous evidence for a decrease in bone mineral density in T1DM. Conclusions: Screening, identification and prevention of potential risk factors for OP in T1DM patients are crucial and important in terms of preserving a good quality of life in diabetic patients. Patient education about an adequate calcium and vitamin D intake and regular exercise are important for improving muscle strength and balance, and specific measures for preventing falls. Furthermore, adequate glycemic control and the prevention of diabetic complications are the starting point of therapy in T1DM. © 2012 The Japan Diabetes Society.
    MeSH terms: Calcium; Osteoporosis; Quality of Life; Vitamin D; Exercise; Bone Density; Muscle Strength
  14. Ooi CP, Yassin Z, Hamid TA
    PMID: 22895968 DOI: 10.1002/14651858.CD007845.pub3
    BACKGROUND: Momordica charantia (bitter gourd) is not only a nutritious vegetable but it is also used in traditional medical practices to treat type 2 diabetes mellitus. Experimental studies with animals and humans suggested that the vegetable has a possible role in glycaemic control.

    OBJECTIVES: To assess the effects of mormodica charantia for type 2 diabetes mellitus.

    SEARCH METHODS: Several electronic databases were searched, among these were The Cochrane Library (Issue 1, 2012), MEDLINE, EMBASE, CINAHL, SIGLE and LILACS (all up to February 2012), combined with handsearches. No language restriction was used.

    SELECTION CRITERIA: We included randomised controlled trials (RCTs) that compared momordica charantia with placebo or a control intervention, with or without pharmacological or non-pharmacological interventions.

    DATA COLLECTION AND ANALYSIS: Two authors independently extracted data. Risk of bias of the trials was evaluated using the parameters of randomisation, allocation concealment, blinding, completeness of outcome data, selective reporting and other potential sources of bias. A meta-analysis was not performed given the quality of data and the variability of preparations of momordica charantia used in the interventions (no similar preparation was tested twice).

    MAIN RESULTS: Four randomised controlled trials with up to three months duration and investigating 479 participants met the inclusion criteria. Risk of bias of these trials (only two studies were published as a full peer-reviewed publication) was generally high. Two RCTs compared the effects of preparations from different parts of the momordica charantia plant with placebo on glycaemic control in type 2 diabetes mellitus. There was no statistically significant difference in the glycaemic control with momordica charantia preparations compared to placebo. When momordica charantia was compared to metformin or glibenclamide, there was also no significant change in reliable parameters of glycaemic control. No serious adverse effects were reported in any trial. No trial investigated death from any cause, morbidity, health-related quality of life or costs.

    AUTHORS' CONCLUSIONS: There is insufficient evidence on the effects of momordica charantia for type 2 diabetes mellitus. Further studies are therefore required to address the issues of standardization and the quality control of preparations. For medical nutritional therapy, further observational trials evaluating the effects of momordica charantia are needed before RCTs are established to guide any recommendations in clinical practice.

    MeSH terms: Diabetes Mellitus, Type 2/drug therapy*; Glyburide/therapeutic use; Humans; Hypoglycemic Agents/therapeutic use*; Phytotherapy/methods*; Metformin/therapeutic use; Plant Extracts/therapeutic use*; Randomized Controlled Trials as Topic; Momordica charantia/chemistry*
  15. Aziz Z, Flemming K
    Cochrane Database Syst Rev, 2012 Dec 12;12:CD002930.
    PMID: 23235593 DOI: 10.1002/14651858.CD002930.pub5
    BACKGROUND: Pressure ulcers are defined as areas "of localized damage to the skin and underlying tissue caused by pressure, shear, friction and/or the combination of these". Electromagnetic therapy (EMT), in which electrodes produce an electromagnetic field across the wound, may improve healing of chronic wounds such as pressure ulcers.

    OBJECTIVES: To assess the effects of EMT on the healing of pressure ulcers.

    SEARCH METHODS: For this update we searched the Cochrane Wounds Group Specialised Register (searched 12 July 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 7); Ovid MEDLINE (2010 to July Week 1 2012); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, July 11, 2012); Ovid EMBASE (2010 to 2012 Week 27); and EBSCO CINAHL (2010 to 6 July 2012).

    SELECTION CRITERIA: Randomised controlled trials comparing EMT with sham EMT or other (standard) treatment.

    DATA COLLECTION AND ANALYSIS: For this update two review authors independently scrutinised the results of the search to identify relevant RCTs and obtained full reports of potentially eligible studies. In previous versions of the review we made attempts to obtain missing data by contacting study authors. A second review author checked data extraction and disagreements were resolved after discussion between review authors.

    MAIN RESULTS: We identified no new trials for this update.Two randomised controlled trials (RCTs), involving 60 participants, at unclear risk of bias were included in the original review. Both trials compared the use of EMT with sham EMT, although one of the trials included a third arm in which only standard therapy was applied. Neither study found a statistically significant difference in complete healing in people treated with EMT compared with those in the control group. In one trial that assessed percentage reduction in wound surface area, the difference between the two groups was reported to be statistically significant in favour of EMT. However, this result should be interpreted with caution as this is a small study and this finding may be due to chance. Additionally, the outcome, percentage reduction in wound area, is less clinically meaningful than complete healing.

    AUTHORS' CONCLUSIONS: The results provide no strong evidence of benefit in using EMT to treat pressure ulcers. However, the possibility of a beneficial or harmful effect cannot be ruled out because there were only two included trials, both with methodological limitations and small numbers of participants. Further research is recommended.

    MeSH terms: Pressure Ulcer/therapy*; Female; Humans; Male; Wound Healing; Randomized Controlled Trials as Topic; Magnetic Field Therapy/methods*
  16. Citation: The fourth report of the National Eye Database 2010. Goh PP, Salowi MA, editors. Kuala Lumpur: Clinical Research Centre; 2012
    MeSH terms: Eye Diseases; Humans; Malaysia; Registries
  17. Citation: Clinical Practice Guidelines: Management of otitis media with effusion in children. Putrajaya: Ministry of Health, Malaysia; 2012

    Keywords: CPG
    MeSH terms: Child; Humans; Malaysia; Otitis Media with Effusion*; Guidelines as Topic
  18. ISBN: 978-967-0339-27-0
    MeSH terms: Hearing Aids; Malaysia; Guideline; Persons With Hearing Impairments; Hearing Loss
  19. MeSH terms: Counseling; Pharmaceutical Preparations; Malaysia; Guideline
  20. Citation: Clinical Practice Guideline. Management of Atrial Fibrillation. Putrajaya: Ministry of Health, Malaysia; 2012

    Keywords: CPG
    MeSH terms: Arrhythmias, Cardiac; Atrial Fibrillation; Cardiology; Humans; Malaysia; Guidelines as Topic
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