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Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

Khan FB 1 , Uddin S 2 , Elderdery AY 3 , Goh KW 4 , Ming LC 5 , Ardianto C 6 Show all authors , Palakot AR 1 , Anwar I 1 , Khan M 7 , Owais M 8 , Huang CY 9 , Daddam JR 10 , Khan MA 11 , Shoaib S 12 , Khursheed M 13 , Reshadat S 14 , Khayat Kashani HR 15 , Mirza S 16 , Khaleel AA 16 , Ayoub MA 1

Affiliations 

  • 1 Department of Biology, College of Science, The United Arab Emirates University, Al Ain 15551, United Arab Emirates
  • 2 Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar
  • 3 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia
  • 4 Faculty of Data Sciences and Information Technology, INTI International University, Nilai 78100, Malaysia
  • 5 PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Gadong BE1410, Brunei
  • 6 Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia
  • 7 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
  • 8 Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, UP, India
  • 9 Department of Biotechnology, Asia University, Taichung 404, Taiwan
  • 10 Department of Ruminant Science, Institute of Animal Sciences, Agriculture Research Organization, Volcani Center, Rishon Lezion 7505101, Israel
  • 11 Program in Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children & DigiBiomics Inc, Toronto, ON M51X8, Canada
  • 12 Department Biochemistry, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002, UP, India
  • 13 College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai 505055, United Arab Emirates
  • 14 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan 3513119111, Iran
  • 15 Imam Hossein Hospital, Madani Street, Tehran 1617763141, Iran
  • 16 Department of Chemistry, United Arab Emirates University, Al Ain 15551, United Arab Emirates
Cells, 2022 Nov 18;11(22).
PMID: 36429092 DOI: 10.3390/cells11223664

Abstract

Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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