Affiliations 

  • 1 Department of Biology, College of Science, The United Arab Emirates University, Al Ain 15551, United Arab Emirates
  • 2 Cell Biology and Proteomics Lab, Animal Biotechnology Center, ICAR-NDRI, Karnal 132001, India
  • 3 King AbdulAziz City of Science and Technology (KACST), Riyadh 12354, Saudi Arabia
  • 4 Department of Pharmacy, University of Malakand, Chakdara 18800, Pakistan
  • 5 Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar
  • 6 Health and Basic Science Research Centre, Majmaah University, Majmaah 11952, Saudi Arabia
  • 7 Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, India
  • 8 Department of Psychiatry, Icahn School of Medicine, Mount Sinai, NY 10029, USA
  • 9 Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
  • 10 Department of Biotechnology, Asia University, Taichung 404, Taiwan
  • 11 Proteomics Lab, National Centre for Cell Science, Pune 411007, India
  • 12 Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia
  • 13 Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
  • 14 Zayed Center for Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates
Cancers (Basel), 2022 Dec 30;15(1).
PMID: 36612248 DOI: 10.3390/cancers15010249

Abstract

Phytochemicals possess various intriguing pharmacological properties against diverse pathological conditions. Extensive studies are on-going to understand the structural/functional properties of phytochemicals as well as the molecular mechanisms of their therapeutic function against various disease conditions. Phytochemicals such as curcumin (Cur), genistein (Gen), and tanshinone-IIA (Tan IIA) have multifaceted therapeutic potentials and various efforts are in progress to understand the molecular dynamics of their function with different tools and technologies. Cur is an active lipophilic polyphenol with pleiotropic function, and it has been shown to possess various intriguing properties including antioxidant, anti-inflammatory, anti-microbial, anticancer, and anti-genotoxic properties besides others beneficial properties. Similarly, Gen (an isoflavone) exhibits a wide range of vital functions including antioxidant, anti-inflammatory, pro-apoptotic, anti-proliferative, anti-angiogenic activities etc. In addition, Tan IIA, a lipophilic compound, possesses antioxidant, anti-angiogenic, anti-inflammatory, anticancer activities, and so on. Over the last few decades, the field of proteomics has garnered great momentum mainly attributed to the recent advancement in mass spectrometry (MS) techniques. It is envisaged that the proteomics technology has considerably contributed to the biomedical research endeavors lately. Interestingly, they have also been explored as a reliable approach to understand the molecular intricacies related to phytochemical-based therapeutic interventions. The present review provides an overview of the proteomics studies performed to unravel the underlying molecular intricacies of various phytochemicals such as Cur, Gen, and Tan IIA. This in-depth study will help the researchers in better understanding of the pharmacological potential of the phytochemicals at the proteomics level. Certainly, this review will be highly instrumental in catalyzing the translational shift from phytochemical-based biomedical research to clinical practice in the near future.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.