Affiliations 

  • 1 Biotechnology and Applied Microbiology Team, Department of Biology, Faculty of Sciences, Abdelmalek Essaadi University, 93000, Tetouan, Morocco
  • 2 Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health, and Quality of Life, Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, Fez, 30050, Morocco
  • 3 Health Research Center, Jazan University, P.O. Box: 114, Jazan, 45142, Saudi Arabia
  • 4 Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia
  • 5 College of Public Health and Tropical Medicine, Jazan University, Jazan, 45142, Saudi Arabia
  • 6 Geo-Bio-Environment Engineering and Innovation Laboratory, Molecular Engineering, Biotechnology and Innovation Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir, 80000, Morocco
  • 7 Department of Biology, Science Faculty, Selcuk University, 42130, Konya, Turkey E-mail: g
  • 8 Sunway Biofunctional Molecules Discovery Centre, School of Medical and Life Sciences, Sunway University, Malaysia, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia
  • 9 Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University, in Rabat, 8007, Rabat, Morocco
Chem Biodivers, 2024 Oct 14.
PMID: 39402872 DOI: 10.1002/cbdv.202401463

Abstract

Bioactive phytochemicals act as important factors with preventive and therapeutic potential in the pathogenesis of several disorders, often related to oxidative stress. Many dietary plant secondary metabolites could lower these conditions. Sorbifolin is one of these metabolites. This work is the first review of sorbifolin, a flavone detected in various plant matrices as a major compound. The present study discussed the natural sources, extraction, purification, quantification, and assessment of the biological activities of sorbifolin. Several databases including Google Scholar, Web of Sciences, and Science-Direct were consulted for relevant English articles related to sorbifolin, the phytochemical profiles of several medicinal plants containing this compound, and its biological activities, such as antioxidant, anticancer, antimicrobial, anti-inflammatory, and antidiabetic. The positive in vitro and in silico outcomes reported in the literature should be followed by additional in vivo and clinical investigations to further research the mechanisms of action, pharmacokinetic/pharmacodynamic activities, toxicological effects, pharmacological properties, and therapeutic potential of sorbifolin.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.