Affiliations 

  • 1 Department of Biotechnology, Dr. A.P.J. Abdul Kalam Technical University, Lucknow 226031, India
  • 2 Department of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, India
  • 3 Chemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai 400019, India
  • 4 Division of Biomedical Informatics, Indian Council of Medical Research, New Delhi 110029, India
  • 5 School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India
  • 6 Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sci-ences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
  • 7 Division of Horticulture, RCSM College of Agriculture, Kolhapur 416004, India
  • 8 Department of Pharmacy, Bhagwant University, Ajmer 305004, India
  • 9 Dr. S. S. Bhatnagar University Institute of Chemical Engineering and Technology, Panjab University, Chandigarh 160014, India
  • 10 Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, India
  • 11 Department of Rural Development and Agricultural Extension, College of Agriculture, Wolaita Sodo University, Wolaita Sodo P.O. Box 138, Ethiopia
  • 12 Department of Food Science and Nutrition, Faculty of Applied Sciences, UCSI University, Kuala Lampur 56000, Malaysia
  • 13 Division of Medicine, Indian Veterinary Research Institute, Bareilly 243122, India
  • 14 School of Agriculture and Biosciences, Karunya Institute of Technology and Sciences, Coimbatore 641114, India
  • 15 Department of Agronomy, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
  • 16 Department of Seed Science and Technology, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
  • 17 Department of Plantation Crops and Spices, Kerala Agricultural University, Vellanikkara, Thrissur 680656, India
  • 18 Department of Soil Science and Agricultural Chemistry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
  • 19 ICAR-National Research Centre for Orchids, Pakyong 737106, India
  • 20 Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Chris-tian-Albrecht's University, 24105 Kiel, Germany
Cells, 2022 Sep 07;11(18).
PMID: 36139367 DOI: 10.3390/cells11182792

Abstract

Stem cells are a well-known autologous pluripotent cell source, having excellent potential to develop into specialized cells, such as brain, skin, and bone marrow cells. The oral cavity is reported to be a rich source of multiple types of oral stem cells, including the dental pulp, mucosal soft tissues, periodontal ligament, and apical papilla. Oral stem cells were useful for both the regeneration of soft tissue components in the dental pulp and mineralized structure regeneration, such as bone or dentin, and can be a viable substitute for traditionally used bone marrow stem cells. In recent years, several studies have reported that plant extracts or compounds promoted the proliferation, differentiation, and survival of different oral stem cells. This review is carried out by following the PRISMA guidelines and focusing mainly on the effects of bioactive compounds on oral stem cell-mediated dental, bone, and neural regeneration. It is observed that in recent years studies were mainly focused on the utilization of oral stem cell-mediated regeneration of bone or dental mesenchymal cells, however, the utility of bioactive compounds on oral stem cell-mediated regeneration requires additional assessment beyond in vitro and in vivo studies, and requires more randomized clinical trials and case studies.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.