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Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review

Almas T 1 , Rehman S 2 , Mansour E 3 , Khedro T 3 , Alansari A 4 , Malik J 5 Show all authors , Alshareef N 3 , Nagarajan VR 3 , Al-Awaid AH 3 , Alsufyani R 3 , Alsufyani M 3 , Rifai A 3 , Alzahrani A 3 , Nagarajan DR 6 , Abdullatif T 7 , Gunasaegaram V 8 , Alzadjali E 3 , Subramanian A 3 , Rahman A 9 , Sattar Y 10 , Galo J 11 , Virk HUH 12 , Alraies MC 13

Affiliations 

  • 1 Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: talalalmas.almas@gmail.com
  • 2 Aga Khan University, Karachi, Pakistan
  • 3 Royal College of Surgeons in Ireland, Dublin, Ireland
  • 4 University Hospital, National University of Ireland Galway, Galway, Ireland
  • 5 Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan
  • 6 Sunway University School of Medicine and Health Science, Malaysia
  • 7 National University of Ireland, Galway, Ireland
  • 8 Galway University Hospital, Galway, Ireland
  • 9 Trinity Centre for Global Health, Trinity College Dublin, Ireland
  • 10 Department of Cardiology, West Virginia University, Morgantown, WV, USA
  • 11 Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA
  • 12 Adena Regional Medical Center, Chillicothe, OH, USA
  • 13 Department of Interventional Cardiology, Detroit Medical Center, DMC Heart Hospital, Detroit, MI, USA
Biomed Pharmacother, 2022 May;149:112843.
PMID: 35325848 DOI: 10.1016/j.biopha.2022.112843

Abstract

The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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