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Role of Natural Cross Linkers in Resin-Dentin Bond Durability: A Systematic Review and Meta-Analysis

Anumula L 1 , Ramesh S 2 , Kolaparthi VSK 3 , Kirubakaran R 4 , Karobari MI 2 , Arora S 5 Show all authors , Saleh AA 5 , Aldowah O 6 , Messina P 7 , Scardina GA 7

Affiliations 

  • 1 Department of Conservative Dentistry and Endodontics, Narayana Dental College and Hospital, Nellore 524003, Andra Pradesh, India
  • 2 Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Chennai 600077, Tamil Nadu, India
  • 3 Department of Oral Medicine and Radiology, Narayana Dental College and Hospital, Nellore 524003, Andra Pradesh, India
  • 4 Cochrane South Asia, BV Moses Centre for Evidence Informed Health Care and Health Policy, Christian Medical College, Vellore 632004, Tamil Nadu, India
  • 5 Department of Restorative Dental Sciences, King Khalid University, P.O. Box 960, Abha 61421, Saudi Arabia
  • 6 Prosthetic Dental Science Department, Faculty of Dentistry, Najran University, Najran 11001, Saudi Arabia
  • 7 Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90133 Palermo, Italy
Materials (Basel), 2022 Aug 17;15(16).
PMID: 36013786 DOI: 10.3390/ma15165650

Abstract

BACKGROUND: The role of endogenous Matrix Metallo Proteinases in resin dentin bond deterioration over time has been well documented. The present study aimed to systematically review the literature; in vitro and ex vivo studies that assessed the outcomes of natural cross-linkers for immediate and long-term tensile bond strength were included.

METHODS: The manuscript search was carried out in six electronic databases-PubMed/MEDLINE, LILACS, SciELO, Cochrane, Web of Science and DOAJ, without publication year limits. Only manuscripts in English (including the translated articles) were selected, and the last search was performed in December 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed.

RESULTS: From the 128 potentially eligible studies, 48 full-text articles were assessed for eligibility. After eligibility assessment and exclusions, 14 studies were considered for systematic review and seven studies for meta-analysis. Amongst the selected studies for meta-analysis, three had a medium and four had a low risk of bias.

CONCLUSIONS: It was evidenced by the available data that Proanthocyanidin is the most efficient natural cross-linker to date, in preserving the bond strength even after ageing.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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