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Epidemiology of adult patients with atopic dermatitis in AWARE 1: A second international survey

Maspero J 1 , De Paula Motta Rubini N 2 , Zhang J 3 , Sanclemente G 4 , Amador JR 5 , El Sayed MH 6 Show all authors , Chan Wai Ming A 7 , Dodiuk-Gad RP 8 , Hamadah I 9 , Thevarajah S 10 , Rincón-Perez C 11 , Fedenko E 12 , Yew YW 13 , Tang MBY 14 , Chu CY 15 , Kulthanan K 16 , Kucuk OS 17 , Al-Hammadi A 18 , Brignoli L 19 , Tsankova A 19 , El-Samad S 20 , Neves JE 21 , Eckert L 22

Affiliations 

  • 1 Fundación CIDEA (Centro de Investigación de Enfermedades Alérgicas y Respiratorias), University of Buenos Aires, Buenos Aires, Argentina
  • 2 Department of Allergy & Immunology, Federal University of Rio de Janeiro (UNIRIO), Brazil
  • 3 Department of Dermatology, Peking University People's Hospital, Beijing, China
  • 4 Group of Investigative Dermatology (GRID), Institute of Medical Research, School of Medicine - University of Antioquia Medellin, Colombia
  • 5 Hospital Militar Central and Universidad Militar Nueva Granada, Bogota, Colombia
  • 6 Department of Dermatology and Venereology, Ain Shams University, Cairo, Egypt
  • 7 Hong Kong Sanatorium and Hospital, Hong Kong, China
  • 8 Dermatology Department, Emek Medical Center, Afula, Israel
  • 9 King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
  • 10 Department of Dermatology, Hospital Kuala Lumpur, Malaysia
  • 11 Ministry of National Defense, Medical Specialties Unit, State of Mexico, Mexico
  • 12 National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, Russia
  • 13 National Skin Centre, Singapore
  • 14 Mount Alvernia Hospital, Singapore
  • 15 Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
  • 16 Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
  • 17 Department of Dermatology, School of Medicine, Bezmialem Vakif University, Istanbul, Turkey
  • 18 Department of Dermatology, Dubai Medical Center, Dubai, United Arab Emirates
  • 19 Kantar Health, Paris, France
  • 20 Sanofi, Dubai, United Arab Emirates
  • 21 Sanofi, Cambridge, MA, USA
  • 22 Sanofi, Chilly-Mazarin, France
World Allergy Organ J, 2023 Mar;16(3):100724.
PMID: 37033301 DOI: 10.1016/j.waojou.2022.100724

Abstract

BACKGROUND: There are gaps in our understanding of the epidemiology of atopic dermatitis (AD) in adults.

OBJECTIVE: To evaluate the prevalence and severity of AD in adults from countries/regions within Asia, Eurasia, Latin America, Middle East, and Russia.

METHODS: This international, web-based survey was performed in Argentina, Brazil, China, Colombia, Egypt, Hong Kong, Israel, Malaysia, Mexico, Russia, Kingdom of Saudi Arabia (KSA), Singapore, Taiwan, Thailand, Turkey, and United Arab Emirates. Questionnaires were sent to adult members of online respondent panels for determination of AD and assessment of severity. A diagnosis of AD required respondents to meet the modified United Kingdom (UK) Working Party criteria and to self-report they had a physician diagnosis of AD. Severity of AD was determined using Patient-Oriented Scoring of Atopic Dermatitis (PO-SCORAD), Patient-Oriented Eczema Measure (POEM), and Patient Global Assessment (PGA).

RESULTS: Among respondents by country/region the prevalence of AD ranged from 3.4% in Israel to 33.7% in Thailand. The prevalence was generally higher in females versus males. Severity varied by scale, although regardless of scale the proportion of respondents with mild and moderate disease was higher than severe disease. PGA consistently resulted in the lowest proportion of severe AD (range 2.4% China - 10.8% Turkey) relative to PO-SCORAD (range 13.4% China - 41.6% KSA) and POEM (range 5.1% China - 16.6% Israel).

CONCLUSIONS: This survey highlights the importance of AD in adults, with high prevalence and high morbidity among respondents and emphasizes that AD is not just a disease of childhood-there is disease persistence and chronicity in adults.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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