Peripheral transbronchial needle aspiration-guided pinpoint cryobiopsy of lung nodule without bronchus sign: A case report

Kho SS 1 , Nyanti LE 2 , Chai CS 1 , Kho SK 3 , Ismail AM 4 , Voon PJ 3 Show all authors , Tie ST 1

Affiliations 

  • 1 Division of Respiratory Medicine, Department of Medicine, Sarawak General Hospital, Ministry of Health Malaysia, Kuching, Sarawak, Malaysia
  • 2 Medical Department, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia. Electronic address: larrynyanti@ums.edu.my
  • 3 Department of Oncology, Sarawak General Hospital, Ministry of Health Malaysia, Sarawak, Malaysia
  • 4 Department of Pathology, Sarawak General Hospital, Ministry of Health Malaysia, Sarawak, Malaysia
Respir Investig, 2023 Jul;61(4):473-477.
PMID: 37182371 DOI: 10.1016/j.resinv.2023.04.003

Abstract

Peripheral transbronchial needle aspiration (pTBNA) allows the access of pulmonary nodules without bronchus sign but is limited to cytological examination. A 39-year-old man with left parotid carcinoma presented with an incidental lung nodule. Target localisation was performed with manual airway mapping, virtual bronchoscopic navigation, and pTBNA. Direct target validation using radial endobronchial ultrasound (rEBUS) was performed through the puncture defect. Targeted pinpoint biopsy with a 1.1 mm cryoprobe through the pTBNA puncture defect confirmed metastatic adenoid cystic carcinoma. Guided pTBNA with rEBUS validation followed by cryobiopsy of lung nodules without bronchus sign is potentially feasible for histological and molecular analyses.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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