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Pathway to global elimination of hepatitis B: HBV cure is just the first step

Howell J 1 , Seaman C 1 , Wallace J 1 , Xiao Y 1 , Scott N 1 , Davies J 2 Show all authors , de Santis T 2 , Adda D 3 , El-Sayed M 4 , Feld JJ 5 , Gane E 6 , Lacombe K 7 , Lesi O 8 , Mohamed R 9 , Silva M 10 , Tu T 11 , Revill P 12 , Hellard ME 1

Affiliations 

  • 1 Disease Elimination, Burnet Institute, Melbourne, Victoria, Australia
  • 2 Department Global Health and Infectious diseases, Menzies School of Public Health, Darwin, Northern Territory, Australia
  • 3 World Hepatitis Alliance, Geneva, Switzerland
  • 4 Department Paediatrics, Ain Shams University, Cairo, Egypt
  • 5 Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Ontario, Canada
  • 6 Department Medicine, University of Auckland, Auckland, New Zealand
  • 7 Sorbonne Université, IPLESP, Saint-Antoine Hospital, AP-HP, Paris, France
  • 8 Global HIV, Hepatitis, and STI Programme, World Health Organisation, Geneva, Switzerland
  • 9 Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 10 Department Hepatology and Liver Transplantation, Austral University Hospital, Buenos Aires, Argentina
  • 11 Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Sydney, New South Wales, Australia
  • 12 Victorian Infectious Diseases Reference Laboratory (VIDRL), Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia
Hepatology, 2023 Sep 01;78(3):976-990.
PMID: 37125643 DOI: 10.1097/HEP.0000000000000430

Abstract

Hepatitis B (HBV) is a major cause of global morbidity and mortality, and the leading cause of liver cancer worldwide. Significant advances have recently been made toward the development of a finite HBV treatment that achieves permanent loss of HBsAg and HBV DNA (so-called "HBV cure"), which could provide the means to eliminate HBV as a public health threat. However, the HBV cure is just one step toward achieving WHO HBV elimination targets by 2030, and much work must be done now to prepare for the successful implementation of the HBV cure. In this review, we describe the required steps to rapidly scale-up future HBV cure equitably. We present key actions required for successful HBV cure implementation, integrated within the World Health Organization (WHO) Global Health Sector Strategy (GHSS) 2022-2030 framework. Finally, we highlight what can be done now to progress toward the 2030 HBV elimination targets using available tools to ensure that we are preparing, but not waiting, for the cure.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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