Affiliations 

  • 1 Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan
  • 2 Department of Civil Engineering, Institute of Energy Infrastructure (IEI), College of Engineering, Universiti Tenaga Nasional (UNITEN), Putrajaya Campus, Jalan IKRAM-UNITEN, 43000, Kajang, Selangor, Malaysia
  • 3 Department of Mathematics, University of Swabi, Swabi, 23561, KPK, Pakistan
  • 4 Department of Mathematical Sciences, University of Lakki Marwat, Lakki Marwat, 28420, KPK, Pakistan. Zahir@ulm.edu.pk
  • 5 Faculty of Engineering, Department of Industrial Machines and Equipments, "Lucian Blaga" University of Sibiu, 10 Victoriei Boulevard, Sibiu, Romania. vrinceanu.narcisai@ulbsibiu.ro
  • 6 Medicine Faculty, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str, 550169, Sibiu, Romania
Sci Rep, 2023 Sep 01;13(1):14398.
PMID: 37658134 DOI: 10.1038/s41598-023-41440-7

Abstract

The burden of vector-borne infections is significant, particularly in low- and middle-income countries where vector populations are high and healthcare infrastructure may be inadequate. Further, studies are required to investigate the key factors of vector-borne infections to provide effective control measure. This study focuses on formulating a mathematical framework to characterize the spread of chikungunya infection in the presence of vaccines and treatments. The research is primarily dedicated to descriptive study and comprehension of dynamic behaviour of chikungunya dynamics. We use Banach's and Schaefer's fixed point theorems to investigate the existence and uniqueness of the suggested chikungunya framework resolution. Additionally, we confirm the Ulam-Hyers stability of the chikungunya system. To assess the impact of various parameters on the dynamics of chikungunya, we examine solution pathways using the Laplace-Adomian method of disintegration. Specifically, to visualise the impacts of fractional order, vaccination, bite rate and treatment computer algorithms are employed on the infection level of chikungunya. Our research identified the framework's essential input settings for managing chikungunya infection. Notably, the intensity of chikungunya infection can be reduced by lowering mosquito bite rates in the affected area. On the other hand, vaccination, memory index or fractional order, and treatment could be used as efficient controlling variables.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.