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Ferritin level: A predictor of severity and mortality in hospitalized COVID-19 patients

Alroomi M 1 , Rajan R 2 , Omar AA 3 , Alsaber A 4 , Pan J 4 , Fatemi M 5 Show all authors , Zhanna KD 6 , Aboelhassan W 7 , Almutairi F 8 , Alotaibi N 9 , Saleh MA 8 , AlNasrallah N 9 , Al-Bader B 8 , Malhas H 10 , Ramadhan M 11 , Abdullah M 1 , Abdelnaby H 12

Affiliations 

  • 1 Department of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait City, Kuwait
  • 2 Department of Cardiology, Sabah Al Ahmad Cardiac Centre, Al Amiri Hospital, Kuwait City, Sharq, Kuwait
  • 3 Department of Medicine, Jaber Al Ahmed Hospital, South Surra, Kuwait
  • 4 Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom
  • 5 Public Health and Commissioning Manager, Nottinghamshire County Council, Nottingham, United Kingdom
  • 6 Department of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics Named after V.S. Moiseev, Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 7 Division of Gastroenterology, Department of Medicine, Jaber Al Ahmed Hospital, South Surra, Kuwait
  • 8 Department of Medicine, Farwaniya Hospital, Farwaniya, Kuwait
  • 9 Department of Medicine, Al Adan Hospital, Hadiya, Kuwait
  • 10 Department of Emergency Medicine, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait
  • 11 Department of Obstetrics and Gynaecology, Maternity Hospital, Shuwaikh Medical Area, Kuwait City, Kuwait
  • 12 Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Immun Inflamm Dis, 2021 Dec;9(4):1648-1655.
PMID: 34438471 DOI: 10.1002/iid3.517

Abstract

INTRODUCTION: This study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels.

METHODS: Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000).

RESULTS: Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21-0.62; p  1000.

CONCLUSION: In this study, higher levels of serum ferritin were found to be an independent predictor of in-hоsрitаl mоrtаlity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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