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Report on hematopoietic cell transplantations performed in 2018/2019 focusing on the trends of selection of stem cell sources in the Asia-Pacific region: APBMT Activity Survey

Iida M 1 , Liu K 2 , Huang XJ 2 , Huang H 3 , Kuwatsuka Y 4 , Moon JH 5 Show all authors , Lee JW 6 , Lakshmi KM 7 , Dodds A 8 , Wilcox L 9 , Ko BS 10 , Hamidieh AA 11 , Behfar M 11 , Ho KW 12 , Bunworasate U 13 , Ho A 14 , Farzana T 15 , Sim J 16 , Dung PC 17 , Akter M 18 , Ratnayake W 19 , Bravo MR 20 , Gyi AA 21 , Santosa D 22 , Poudyal BS 23 , Batshkh K 24 , Srivastava A 7 , Okamoto S 25 , Atsuta Y 26 , Registry Committee of the Asia-Pacific Blood and Marrow Transplantation Group (APBMT)

Affiliations 

  • 1 Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan
  • 2 Department of Hematology, Peking University Institute of Hematology, Beijing, China
  • 3 Department of Hematology, Zhejian University, Zhejiang, China
  • 4 Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan
  • 5 Division of Hematology-Oncology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea
  • 6 Division of Hematology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea
  • 7 Department of Hematology, Christian Medical College Hospital, Vellore, India
  • 8 St. Vincent's Hospital Sydney, Sydney
  • 9 Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Sydney, Australia
  • 10 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
  • 11 Pediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  • 12 Department of Hematology, Hospital Ampang, Ampang Selangor, Malaysia
  • 13 Division of Hematology and Center of Excellence in Translational Hematology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
  • 14 Department of Hematology, Singapore General Hospital, Singapore, Singapore
  • 15 Department of Clinical Hematology, National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, Pakistan
  • 16 Department of Medicine, Queen Mary Hospital, Hong Kong
  • 17 Stem Cell Transplantation Department, Blood Transfusion and Hematology Hospital, Ho Chi Minh, Vietnam
  • 18 Department of Hematology and BMT, Dhaka Medical College and Hospital, Dhaka, Bangladesh
  • 19 Bone Marrow Transplant Unit, Nawaloka Hospital PLC, Colombo, Sri Lanka
  • 20 St Luke's Medical Center Quezon City, IM Hematology/Blood and Marrow Transplant, Quezon, the Philippines
  • 21 Department of Clinical Hematology, North Okkalapa General Hospital, Yangon, Myanmar
  • 22 Division of Hematology Medical Oncology, Depatment of Internal Medicine, Dr. Kariadi Hospital/Diponegoro University, Semarang, Indonesia
  • 23 Civil Service Hospital, Clinical Hematology and Bone Marrow Transplant Unit, Kathmandu, Nepal
  • 24 Bone and Marrow transplantation team, Hematology Department, National First Central Hospital of Mongolia, Ulaanbaatar, Mongolia
  • 25 Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • 26 Japanese Data Center for Hematopoietic Cell Transplantation (JDCHCT), Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan
Blood Cell Ther, 2023 Nov 25;6(4):114-123.
PMID: 38149021 DOI: 10.31547/bct-2023-015

Abstract

The number of hematopoietic stem cell transplantations (HCTs) is increasing annually worldwide, and the Asia-Pacific (AP) region is no exception. We report on the absolute number of HCTs in 2018 and 2019 and the trends in graft selection and disease indication in the past few decades. In 2018, 24,292 HCTs were performed in the AP region, of which 8,754 (36.0%) were autologous and 15,538 (64.0%) were allogeneic. Among the allogeneic HCTs, 10,552 (67.9%) of the recipients were related to their donors, whereas 4,986 (32.1%) were unrelated. In 2019, 27,583 HCTs were reported, of which 17,613 (63.9%) were allogeneic and 9,970 (36.1%) were autologous. Although, in 2010, there was a nearly equal number of related and unrelated HCTs, the difference has shown an annual increase, with more than double (2.05) the number of related than unrelated HCTs in 2019. Recent trends in the AP region show that peripheral blood has overwhelmingly surpassed the bone marrow as a graft source for both related and unrelated HCTs, with the haploidentical donor type being preferred; however, their trends in each country/region were quite different among countries/regions. In 2019, the main conditions requiring HCT were acute myelogenous leukemia (n=6,629 [24.0%]), plasma cell disorders (PCD) (n=4,935 [17.9%]), malignant lymphoma (ML) (n=4,106 [14.9%]), acute lymphoblastic leukemia (AML) (n=3,777 [13.7%]), myelodysplastic syndrome or myelodysplastic/myeloproliferative neoplasm (n=1,913 [6.9%]), severe aplastic anemia (n=1,671 [6.1%]), and hemoglobinopathy (n=910 [3.3%]). PCD and ML were the main indications for autologous HCT, and the number of PCD cases has grown more prominent than the corresponding of ML. The increased number of allogeneic transplants for hemoglobinopathy remains prominent, as well as that of AML and acute lymphocytic leukemia for the past 5 years. There was a significant regional variation in the number of facilities performing HCTs, ranging from one in Mongolia and Nepal to 313 in Japan, and differing regional densities varying from 0.1 in Indonesia and Pakistan to 24.7 in Japan. The total transplant density per 10 million population in each country/region also differed (0.2 in Indonesia and 627 in New Zealand). This annual Activity Survey aims to help all participating countries/regions understand the changes in HCT, serve as an asset in promoting HCT activities in the AP region, and be used as a reference for comparison with other registries from Europe and the United States.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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