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Advances in hematopoietic stem cell transplantation in the Asia-Pacific region: the second report from APBMT 2005-2015

Iida M 1 , Kodera Y 2 , Dodds A 3 , Ho AYL 4 , Nivison-Smith I 5 , Akter MR 6 Show all authors , Wu T 7 , Lie AKW 8 , Ghavamzadeh A 9 , Kang HJ 10 , Ong TC 11 , Gyi AA 12 , Farzana T 13 , Baylon H 14 , Gooneratne L 15 , Tang JL 16 , Bunworasate U 17 , Huynh VM 18 , Srivastava A 19 , Okamoto S 20 , Atsuta Y 21 , Registry Committee of the Asia-Pacific Blood and Marrow Transplantation Group (APBMT)

Affiliations 

  • 1 Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan. miida@aichi-med-u.ac.jp
  • 2 Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan
  • 3 St. Vincent's Pathology, St. Vincent's Health Network Sydney, Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Sydney, Australia
  • 4 Department of Haematology, Singapore General Hospital, Singapore, Singapore
  • 5 Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Sydney, Australia
  • 6 Department of Hematology & BMT, Dhaka Medical College & Hospital, Dhaka, Bangladesh
  • 7 Department of Bone Marrow Transplantation, Ludaopei, Hematology & Oncology Center, Yanda International Hospital, Hebei, China
  • 8 Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong Kong
  • 9 Hematology, Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • 10 Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, South Korea
  • 11 Department of Haematology, Ampang Hospital, Selangor Darul Ehsan, Malaysia
  • 12 Department of Clinical Haematology, North Okkalapa General Hospital, Yangon, Myanmar
  • 13 Department of Clinical Haematology, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan
  • 14 Blood and Marrow Transplant Center, St. Luke's Medical Center, Quezon City, Philippines
  • 15 Faculty of Medicine, Sri Lanka and Central Hospital, University of Colombo, Colombo, Sri Lanka
  • 16 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
  • 17 Research Collaborations in Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Division of Hematology, Chulalongkorn University, Bangkok, Thailand
  • 18 Stem cell transplantation department, Blood Transfusion and Hematology Hospital, Ho Chi Minh, Vietnam
  • 19 Department of Haematology, Christian Medical College Hospital, Vellore, India
  • 20 Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • 21 Japanese Data Center for Hematopoietic Cell Transplantation (JDCHCT), Nagoya, Japan
Bone Marrow Transplant, 2019 Dec;54(12):1973-1986.
PMID: 31089289 DOI: 10.1038/s41409-019-0554-9

Abstract

Between 2005 and 2015, 138,165 hematopoietic stem cell transplantation (HSCT) were reported in 18 countries/regions in the Asia-Pacific region. In this report, we describe current trends in HSCT throughout the Asia-Pacific region and differences among nations in this region and various global registries. Since 2008, more than 10,000 HSCTs have been recorded each year by the Asia-Pacific Blood and Marrow Transplantation Group Data Center. Between 2005 and 2015, the greatest increase in the number of HSCTs was observed in Vietnam. Allogeneic HSCT was performed more frequently than autologous HSCT, and a majority of cases involved related donors. Regarding allogeneic HSCT, the use of cord blood has remained steady, especially in Japan, and the number of cases involving related HLA non-identical donors has increased rapidly, particularly in China. The incidence of hemoglobinopathy, a main indication for allogeneic HSCT in India, China, Iran, and Pakistan, increased nearly six-fold over the last decade. Among the 18 participating countries/regions, the transplant rate per population varied widely according to the absolute number of HSCTs and the national/regional population size. We believe that this report will not only benefit the AP region but will also provide information about HSCT to other regions worldwide.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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