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Nasal epithelial cells can act as a physiological surrogate for paediatric asthma studies

Thavagnanam S 1 , Parker JC 2 , McBrien ME 3 , Skibinski G 2 , Shields MD 4 , Heaney LG 2

Affiliations 

  • 1 Paediatric Department, University Malaya Medical Centre, Kuala Lumpar, Malaysia
  • 2 Centre for Infection and Immunity, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
  • 3 Department of Anaesthetics, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom
  • 4 Centre for Infection and Immunity, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom ; Department of Paediatrics, Royal Belfast Hospital for Sick Children, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom
PLoS One, 2014;9(1):e85802.
PMID: 24475053 DOI: 10.1371/journal.pone.0085802

Abstract

Differentiated paediatric epithelial cells can be used to study the role of epithelial cells in asthma. Nasal epithelial cells are easier to obtain and may act as a surrogate for bronchial epithelium in asthma studies. We assessed the suitability of nasal epithelium from asthmatic children to be a surrogate for bronchial epithelium using air-liquid interface cultures.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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