Fostering healthy cognitive ageing in people living with HIV

Cysique LA 1 , Levin J 2 , Howard C 3 , Taylor J 4 , Rule J 5 , Costello J 6 Show all authors , Bruning J 7 , Njeri P 6 , Mullens AB 8 , Wright E 9 , Gouse H 10 , Daken K 8 , Trunfio M 11 , Aung HL 12 , Robbins RN 13 , Ferraris CM 13 , Muñoz-Moreno JA 14 , Woods SP 15 , Moore DJ 16 , Power C 17 , Wong PL 18 , Hasmukharay K 19 , Nyamayaro P 20 , Vera J 21 , Rajasuriar R 18 , Heaton RK 16 , Goodkin K 22 , Letendre S 16 , Ellis RJ 16 , Brew BJ 23 , Rourke SB 24 , NeuroHIV and Aging Advocacy Group

Affiliations 

  • 1 MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Peter Duncan Neuroscience Research Unit, St Vincent's Centre for Applied Medical Research, Darlinghurst, NSW, Australia; School of Psychology, University of New South Wales, Sydney, NSW, Australia; The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address: lcysique@unsw.edu.au
  • 2 National AIDS Treatment Advocacy Project, New York, NY, USA
  • 3 Queensland Positive People, Brisbane, QLD, Australia
  • 4 HIV+Aging Research Project-Palm Springs, Palm Springs, CA, USA
  • 5 National Association of People with HIV Australia, Newtown, NSW, Australia
  • 6 Positive Life New South Wales, Surry Hills, NSW, Australia
  • 7 Positive Women, Auckland, Aotearoa New Zealand
  • 8 School of Psychology & Wellbeing, Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Brisbane, QLD, Australia
  • 9 Department of Infectious Disease, Alfred Health, Melbourne, VIC, Australia; Burnet Institute, Melbourne, VIC, Australia; Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia; The Peter Doherty Institute of Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia
  • 10 Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
  • 11 Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Department of Medical Sciences, University of Turin, Turin, Italy
  • 12 The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
  • 13 HIV Center for Clinical and Behavioral Studies, Columbia University and the New York State Psychiatric Institute, New York, NY, USA
  • 14 Fight Infections Foundation, Infectious Diseases Department, Germans Trias Hospital, Barcelona, Spain; Faculty of Psychology and Education Sciences, Open University of Catalonia, Barcelona, Spain
  • 15 Department of Psychology, University of Houston, Houston, TX, USA
  • 16 Department of Psychiatry, University of California San Diego, San Diego, CA, USA
  • 17 Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada
  • 18 Department of Medicine and Centre of Excellence for Research in AIDS, University Malaya, Kuala Lumpur, Malaysia
  • 19 Geriatric Unit, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
  • 20 Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe
  • 21 Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, UK
  • 22 Department of Psychiatry, University of Texas Rio Grande Valley, Harlingen, TX, USA
  • 23 Peter Duncan Neuroscience Research Unit, St Vincent's Centre for Applied Medical Research, Darlinghurst, NSW, Australia; Department of Neurology and Department of Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
  • 24 MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Lancet HIV, 2024 Nov 27.
PMID: 39615509 DOI: 10.1016/S2352-3018(24)00248-0

Abstract

Prevalence and incidence of HIV among people aged 50 years and older continue to rise worldwide, generating increasing awareness among care providers, scientists, and the HIV community about the importance of brain health in older adults with HIV. Many age-related factors that adversely affect brain health can occur earlier and more often among people with HIV, including epigenetic ageing, chronic medical conditions (eg, cardiovascular disease), and age-related syndromes (eg, frailty). Extensive dialogue between HIV community leaders, health-care providers, and scientists has led to the development of a multidimensional response strategy to protect and enhance brain health in people ageing with HIV that spans across public health, clinical spaces, and research spaces. This response strategy was informed by integrated ageing care frameworks and is centred on prevention, early detection, and management of brain health issues associated with HIV (eg, neurocognitive disorders), with specific considerations for low-resource or middle-resource countries. A collaborative, international, and data-informed update of the diagnostic criteria for HIV-associated neurocognitive disorders is a cornerstone of the proposed response strategy. The proposed response strategy includes a dynamic, international, online knowledge hub that will provide a crucial community resource for emerging evidence on the brain health of people ageing with HIV.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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