Affiliations 

  • 1 Assistant Professor, Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh Saudi Arabia, Phone: +966 1 467-7422, Fax: 966 1 467-9018 e-mail: kamranhabibawan@gmail.com
  • 2 Associate Professor, Department of Oral Pathology, Faculty of Dental Sciences MS Ramaiah University of Applied Sciences, Bengaluru Karnataka, India
  • 3 Assistant Professor, Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia
  • 4 Assistant Professor, Department of Periodontology and Oral Medicine, Medical Faculty, University of Nis, Nis, Serbia
  • 5 Professor, Department of Oral and Maxillofacial Surgical and Medical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
J Contemp Dent Pract, 2014 Nov 1;15(6):812-7.
PMID: 25825114

Abstract

Oral submucous fibrosis is a chronic, progressive scarring disease associated with both significant morbidity including pain and limited mouth opening and an increased risk for malignancy. This systematic review evaluated the different medicinal (i.e. nonsurgical) interventions available for the management of oral submucous fibrosis. An automated literature searches of online databases from January 1960 to December 2013 were performed and only studies with high level of evidence based on the guidelines of the Oxford Centre for evidence-based medicine were selected. Thirteen studies (3 randomized controlled trials and 10 clinical trials/controlled clinical trials) were included and drugs like steroids, hyaluronidase, human placenta extracts, chymotrypsin and collagenase, pentoxifylline, nylidrin hydrochloride, iron and multivitamin supplements including lycopene were used. There is a clear lack of evidence on the available drug treatment for oral submucous fibrosis and further high quality randomized controlled trials are needed to evaluate the different therapeutic agents.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.