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Efficacy of bisphosphonate as an adjunct to nonsurgical periodontal therapy in the management of periodontal disease: a systematic review

Akram Z 1 , Abduljabbar T 2 , Kellesarian SV 3 , Abu Hassan MI 4 , Javed F 3 , Vohra F 2

Affiliations 

  • 1 Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, 75600, Pakistan
  • 2 Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia
  • 3 Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, New York, 14620, USA
  • 4 Dean, Faculty of Dentistry, University Technology MARA, Shah Alam, Malaysia
Br J Clin Pharmacol, 2017 03;83(3):444-454.
PMID: 27718252 DOI: 10.1111/bcp.13147

Abstract

AIMS: The aim of this systematic review was to assess the efficacy of bisphosphonate therapy as an adjunct to scaling and root planing (SRP) in the management of periodontitis.

METHODS: Databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases) were searched up to and including July 2016. The primary outcome was probing depth (PD), and the secondary outcomes were changes in clinical attachment level (CAL) and bone defect (BD) fill. The mean differences (MD) of outcomes and 95% confidence intervals (CI) for each variable were calculated using random effect model.

RESULTS: Eight clinical studies were included. Seven studies used alendronate as an adjunct to SRP; of these, four studies used topical application and three used oral alendronate. Considering the effects of adjunctive bisphosphonates as compared to SRP alone, a high degree of heterogeneity for PD (Q value = 39.6, P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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