Affiliations 

  • 1 Office of the Deputy Director, Tumor Radiotherapy and Treatment Department, Chifeng Cancer Hospital (The Second Affiliated Hospital of Chifeng University), Chifeng City State Cancer Prevention and Treatment Center, Chifeng University, 024000, China
  • 2 Facultad de Medicina, Universidat Autonoma de Barcelona, 08203 Bellaterra, Spain
  • 3 Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d Hebron Institute de Recerca (VHIR), Vall Hebron Hospital Universitari, Vall d Hebron Barcelona Hospital Campus, Barcelona, Spain
  • 4 Ninth Clinical Medical College, Department of Medicine, Peking University, Peking 100000, China
Curr Pharm Biotechnol, 2025 Feb 18.
PMID: 39976033 DOI: 10.2174/0113892010348489241210060447

Abstract

OBJECTIVE: The objective of this study is to conduct network toxicology analysis based on smoking habits and develop a simpler and more effective toxicology product ingestion control system.

BACKGROUND: Smoking behavior can affect the pathogenesis and prognosis of neuroimmune gastrointestinal diseases.

AIMS: The purpose of developing tools to assist clinical practice is to avoid the harm of cigarettes to the human body.

METHODS: Molecular dynamics method was used to elucidate the biophysical mechanism of TP53 gene mutation caused by harmful ingredients, and the signaling pathway of midbrain edge excitation was determined by molecular dynamics of nicotine and dopamine receptor D3. The possible involvement of nicotine in neuronal damage was determined through the molecular interaction between nicotine and ACHE. Molecular pathways were analyzed based on the aforementioned biological principles, developed artificial intelligence systems and brain computer interface systems.

RESULTS: Several signaling pathways were elucidated, and effective AI algorithms were developed.

CONCLUSION: The accuracy of artificial intelligence systems is over 70%. This study provides clinical doctors with a new precision medicine strategy and tool to regulate patient behavior and reduce disease risk. Other: This project was approved by the Ethics Committee of Chifeng Cancer Hospital and reported to the WHO.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.