Hyaluronic acid based approaches for wound healing: A comprehensive review

Parmal S 1 , Subbappa P 2 , Nikam V 1 , Tarwate Y 1 , Barhate K 1 , Wagh S 1 Show all authors , Gholap A 3 , Dua K 4 , Singh SK 5 , Parikh D 6 , Shaikh M 7 , Khan T 8 , Rajput A 9

Affiliations 

  • 1 Department of Pharmaceutics, Bharti Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India
  • 2 Alliance Management and Supply Chain, Azurity Pharmaceuticals, Inc., 8 Cabot Road, Suite 2000, Woburn, MA 01801, USA
  • 3 Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, Maharashtra, India; Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner 422608, Maharashtra, India
  • 4 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo 2007, Australia
  • 5 Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo 2007, Australia; Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; School of Medical and Life Sciences, Sunway University, 47500 Sunway City, Malaysia
  • 6 Department of Pharmaceutics, Institute of Pharmacy, Nirma University, S.G. Highway, Ahmedabad 382481, Gujarat, India
  • 7 Vivekanand Education Society's College of Pharmacy, Chembur (East), Mumbai 400074, Maharashtra, India
  • 8 GN Khalsa College of Art Science and Commerce, Matunga (East), Mumbai 400019, Maharashtra, India
  • 9 Department of Pharmaceutics, Bharti Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India. Electronic address: amarjit.rajput@bharatividyapeeth.edu
Int J Biol Macromol, 2025 Mar 04.
PMID: 40049471 DOI: 10.1016/j.ijbiomac.2025.141625

Abstract

Wound healing is a natural, however complex, tissue repair and regeneration mechanism. Understanding the cascade of biological events associated with wound healing facilitates scientists in designing topical skin formulations with enhanced therapeutic outcomes. In recent years, several innovative approaches have been utilized to treat wounds. Hyaluronic acid (HA)-based formulations have shown promising results. The current manuscript provides a systematic review of various aspects of HA, including its structure, synthesis, mechanism involved in wound healing, and various formulations developed using HA to treat wounds. Covered are innovative treatment strategies explicitly emphasizing nanocarrier-based approaches. Various patents wherein HA has been used to treat wounds are also summarized with the help of a Google patent search. Diving deep, clinical perspectives, toxicity aspects, and application of computational chemistry in HA research are also discussed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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