Global Prevalence of Excessive Daytime Sleepiness in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Salari N 1 , Gholami A 2 , Jalili F 3 , Zereshki E 4 , Heidarian P 5 , Shohaimi S 6 Show all authors , Mohammadi M 7

Affiliations 

  • 1 Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 2 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 3 School of Health Administration, Dalhousie University, Halifax, NS Canada
  • 4 Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 5 Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 6 Department of Biology, Faculty of Science, University Putra Malaysia, Serdang, Selangor Malaysia
  • 7 Research Center for NonCommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran
Indian J Otolaryngol Head Neck Surg, 2025 Jan;77(1):216-223.
PMID: 40066425 DOI: 10.1007/s12070-024-05146-0

Abstract

The prevalence of obstructive sleep apnea (OSA) has increased worldwide in recent years, becoming a significant public health concern. One of the most important complications experienced by individuals with OSA is excessive daytime sleepiness (EDS). This study aims to investigate the prevalence of EDS in patients with OSA through a systematic review and meta-analysis. Electronic databases including PubMed, Scopus, Web of Science, Embase, ScienceDirect, and the Google Scholar search engine were systematically searched for studies investigating the prevalence of EDS in people with OSA up to December 2023. Data analysis was conducted using Comprehensive Meta-Analysis software (Version 2), employing a random effects model. The heterogeneity of the studies was assessed using the I² index. In review of 15 studies with a combined sample size of 42,924 individuals found that the global prevalence of EDS in patients with OSA was 39.9% (95% CI: 34.4-45.7). The regression results indicated that as the sample size increased, the prevalence of EDS in patients with OSA decreased (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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