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The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis

Salari N 1 , Heydari M 2 , Hassanabadi M 3 , Kazeminia M 4 , Farshchian N 5 , Niaparast M 6 Show all authors , Solaymaninasab Y 7 , Mohammadi M 8 , Shohaimi S 9 , Daneshkhah A 10

Affiliations 

  • 1 Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 2 Department of General Surgery, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 3 Lecturer in International Business & Strategy, Faculty of Business & Law, University of Northampton, Northampton, UK
  • 4 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 5 Department of Otolaryngology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 6 Department of Statistics, Razi University, Kermanshah, Iran
  • 7 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. yousef.1375@gmail.com
  • 8 Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran. Masoud.mohammadi1989@yahoo.com
  • 9 Department of Biology, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia
  • 10 School of Computing, Electronics and Maths, Coventry University, London, UK
J Orthop Surg Res, 2020 Oct 28;15(1):495.
PMID: 33115483 DOI: 10.1186/s13018-020-01999-7

Abstract

BACKGROUND: The Dupuytren disease is a benign fibroproliferative disorder that leads to the formation of the collagen knots and fibres in the palmar fascia. The previous studies reveal different levels of Dupuytren's prevalence worldwide; hence, this study uses meta-analysis to approximate the prevalence of Dupuytren globally.

METHODS: In this study, systematic review and meta-analysis have been conducted on the previous studies focused on the prevalence of the Dupuytren disease. The search keywords were Prevalence, Prevalent, Epidemiology, Dupuytren Contracture, Dupuytren and Incidence. Subsequently, SID, MagIran, ScienceDirect, Embase, Scopus, PubMed and Web of Science databases and Google Scholar search engine were searched without a lower time limit and until June 2020. In order to analyse reliable studies, the stochastic effects model was used and the I2 index was applied to test the heterogeneity of the selected studies. Data analysis was performed within the Comprehensive Meta-Analysis Software version 2.0.

RESULTS: By evaluating 85 studies (10 in Asia, 56 in Europe, 2 in Africa and 17 studies in America) with a total sample size of 6628506 individuals, the prevalence of Dupuytren disease in the world is found as 8.2% (95% CI 5.7-11.7%). The highest prevalence rate is reported in Africa with 17.2% (95% CI 13-22.3%). According to the subgroup analysis, in terms of underlying diseases, the highest prevalence was obtained in patients with type 1 diabetes with 34.1% (95% CI 25-44.6%). The results of meta-regression revealed a decreasing trend in the prevalence of Dupuytren disease by increasing the sample size and the research year (P < 0.05).

CONCLUSION: The results of this study show that the prevalence of Dupuytren disease is particularly higher in alcoholic patients with diabetes. Therefore, the officials of the World Health Organization should design measures for the prevention and treatment of this disease.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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