Photodynamic antibacterial activity of green-synthesized gold nanoparticles from mangosteen peel extract using blue laser irradiation

Arifianto D 1 , Astuti SD 2 , Lusiani BM 3 , Zaidan AH 3 , Winarno W 3 , Yaqubi AK 3 Show all authors , Susilo Y 4 , Qadir KW 5 , Syahrom A 6

Affiliations 

  • 1 Faculty of Science and Technology, Airlangga University, Surabaya, East Java, 60115, Indonesia
  • 2 Department of Physics, Faculty of Science and Technology, Airlangga University, Surabaya, 60115, Indonesia. suryanidyah@fst.unair.ac.id
  • 3 Department of Physics, Faculty of Science and Technology, Airlangga University, Surabaya, 60115, Indonesia
  • 4 Faculty of Engineering, Universitas Dr Soetomo Surabaya, Surabaya, 60118, Indonesia
  • 5 Departement of Physics, College of Education, Salahaddin University, Erbyl, Iraq
  • 6 Medical Devices and Technology Centre, Universiti Teknologi Malaysia, Bahru, 81310, Malaysia
Lasers Med Sci, 2025 Jun 30;40(1):305.
PMID: 40583083 DOI: 10.1007/s10103-025-04549-x

Abstract

INTRODUCTION: diseases caused by antibiotic-resistant bacteria pose a growing global health challenge. Photodynamic Therapy (PDT), which uses light-activated photosensitizers to kill bacteria, offers a promising alternative. This study evaluates the antibacterial efficacy of gold nanoparticles synthesized from mangosteen peel extract (AuNPs-GML) combined with blue diode laser irradiation against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), two common pathogens.

MATERIALS AND METHODS: Four treatments were applied: control (no treatment), AuNPs-GML alone, blue laser irradiation alone (405 nm), and a combination of AuNPs-GML with laser irradiation. Samples were incubated at 37 °C for 24 h before bacterial viability was assessed. Statistical analysis was performed using Two-Way ANOVA and Tukey's post hoc test (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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