Reduced bone mineral density in Southeast Asian children with Crohn's disease: Prevalence and predictors

Ser GTZ 1 , Chew KS 2 , Choong CL 3 , Lee WS 4

Affiliations 

  • 1 Department of Paediatrics, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia
  • 2 Department of Paediatrics, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. Electronic address: kschew@ummc.edu.my
  • 3 Department of Paediatrics, Hospital Pulau Pinang, Penang, Malaysia
  • 4 Department of Paediatrics, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia; Department of Population Medicine, M. Kandiah Faculty of Medicine and Health Sciences, University Tunku Abdul Rahman, Kajang, Malaysia
Pediatr Neonatol, 2026 Oct 24.
PMID: 42982651 DOI: 10.1016/j.pedneo.2026.06.015

Abstract

BACKGROUND: Reduced bone mineral density (BMD) is an important but under-recognized complication of pediatric Crohn's disease (CD). Prevalence data from Southeast Asia is limited. We studied the prevalence of reduced BMD and identified its associated risk factors in a multiethnic Southeast Asian children cohort with CD.

METHODS: A retrospective cross-sectional study was conducted involving all children (<18 years) with CD across 10 years in two tertiary centers. Data on demography, clinical characteristics, laboratory parameters, dual-energy X-ray absorptiometry (DXA) reports, and treatment were analyzed. Suboptimal and low BMD were defined as lumbar BMD Z-scores of 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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