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Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro

Abu N 1 , Akhtar MN 2 , Yeap SK 3 , Lim KL 4 , Ho WY 5 , Abdullah MP 6 Show all authors , Ho CL 7 , Omar AR 8 , Ismail J 9 , Alitheen NB 10

Affiliations 

  • 1 Bright Sparks Unit, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. nadyaboo@gmail.com
  • 2 Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Kuantan, Pahang, Malaysia. nadeemupm@gmail.com
  • 3 Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Darul Ehsan, Malaysia. sky2005@gmail.com
  • 4 Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Lot PT 21144, Jalan Sungai Long, Bandar Sungai Long, Cheras, 43000, Selangor, Malaysia. promelkl@gmail.com
  • 5 School of Biomedical Sciences, University of Nottingham Malaysia Campus, Jalan Broga, Semenyih 43500, Selangor, Malaysia. wanyong.ho@nottingham.edu.my
  • 6 Faculty of Biotechnology and Bimolecular Sciences, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Darul Ehsan, Malaysia. puad@upm.edu.my
  • 7 Faculty of Biotechnology and Bimolecular Sciences, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Darul Ehsan, Malaysia. clho@upm.edu.my
  • 8 Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Darul Ehsan, Malaysia. aro@upm.edu.my
  • 9 Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Kuantan, Pahang, Malaysia. jamilismail@ump.edu.my
  • 10 Faculty of Biotechnology and Bimolecular Sciences, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Darul Ehsan, Malaysia. noorjahan@upm.edu.my
BMC Complement Altern Med, 2016;16:86.
PMID: 26922065 DOI: 10.1186/s12906-016-1046-8

Abstract

The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mechanism of the anti-cancer activity of a synthetic Flavokawain B (FKB) on two breast cancer cell lines, MCF-7 and MDA-MB231 was investigated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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