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Genetic diversity and natural selection in the rhoptry-associated protein 1 (RAP-1) of recent Plasmodium knowlesi clinical isolates from Malaysia

Rawa MS 1 , Fong MY 2 , Lau YL 3

Affiliations 

  • 1 Faculty of Medicine, Department of Parasitology, University of Malaya, 50603, Kuala Lumpur, Malaysia. mirasyah@buffalo.edu
  • 2 Faculty of Medicine, Department of Parasitology, University of Malaya, 50603, Kuala Lumpur, Malaysia. fongmy@um.edu.my
  • 3 Faculty of Medicine, Department of Parasitology, University of Malaya, 50603, Kuala Lumpur, Malaysia. lauyeeling@um.edu.my
Malar J, 2016;15:62.
PMID: 26847346 DOI: 10.1186/s12936-016-1127-7

Abstract

The Plasmodium rhoptry-associated protein 1 (RAP-1) plays a role in the formation of the parasitophorous vacuole following the parasite's invasion of red blood cells. Although there is some evidence that the protein is recognized by the host's immune system, study of Plasmodium falciparum RAP-1 (PfRAP-1) suggests that it is not under immune pressure. A previous study on five old (1953-1962) P. knowlesi strains suggested that RAP-1 has limited genetic polymorphism and might be under negative selection. In the present study, 30 recent P. knowlesi isolates were studied to obtain a better insight into the polymorphism and natural selection of PkRAP-1.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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