• 1 Department of Diagnostic Imaging, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
Biomed Imaging Interv J, 2010 Jan-Mar;6(1):e6.
PMID: 21611066 MyJurnal DOI: 10.2349/biij.6.1.e6


Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern in a child with neurological problems should prompt the clinician to investigate for Leigh syndrome. We present here two cases of Leigh syndrome due to different biochemical/genetic defects, and discuss the subtle differences in their MR neuroimaging features.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.