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Pituitary thyroid resistance syndrome

Norlela S 1 , Nor Azmi K 2 , Khalid BAK 3

Affiliations 

  • 1 S Norlela, MMed. Endocrine Unit, Department of Medicine, Faculty of Medicine Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur
  • 2 K Nor Azmi, MMed. Endocrine Unit, Department of Medicine, Faculty of Medicine Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur
  • 3 B A K Khalid, FRACP. Endocrine Unit, Department of Medicine, Faculty of Medicine Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur
Med J Malaysia, 2005 Dec;60(5):642-3.
PMID: 16515117

Abstract

Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by goiter and biochemically by elevated circulating free thyroid hormone levels in the presence of measurable serum thyroid-stimulating hormone (TSH) concentrations. About 85% of patients with RTH harbor mutations in thyroid hormone receptor [beta] (TR[beta]). Even rarer is pituitary thyroid resistance syndrome. We report a case of a 35-year-old man who presented with hypermetabolic symptoms with elevated levels of thyroid hormones, associated with nonsuppressed thyrotropin (TSH). When treated with anti-thyroid drugs, his thyroid hormone levels normalized and TSH increased, suggesting thyroid resistance at the pituitary level.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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