Affiliations 

  • 1 B A Zilfalil, MMed. Department of Pediatrics, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • 2 A M H Zabidi-Hussin, FRCPCH. Department of Pediatrics, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • 3 M S Watihayati, BSc. Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • 4 M Y Rozainah, BSc. Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • 5 L Naing, MMedStat. Biostatistician, School of Dental Sciences, Universiti Sains Malaysia, Malaysia
  • 6 R Sutomo, PhD. Department of Public Health, Kobe University School of Medicine, Japan
  • 7 H Nishio, PhD. Department of Public Health, Kobe University School of Medicine, Japan
  • 8 M Y Narazah, PhD. Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • 9 M Matsuo, PhD. Department of Paediatrics, Kobe University School of Medicine, Japan
Med J Malaysia, 2004 Oct;59(4):512-4.
PMID: 15779584 MyJurnal

Abstract

In Malaysia, Spinal Muscular Atrophy (SMA) is diagnosed based on clinical observation with or without muscle biopsy. Molecular analyses of the SMA-related genes have not been available so far. In this preliminary study, we searched for homozygous deletion of Survival Motor Neuron (SMN1) and Neuronal Apoptosis Inhibitory Protein (NAIP) genes in Malay patients with SMA and found homozygous deletion of SMN1 exon 7 and 8 in all the patients while homozygous deletion of NAIP exon 5 was detected in only our type 1 patients but not in the type 3 patient. To the best of our knowledge, these are the first SMA cases diagnosed at the molecular level in Malaysia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.