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Depletion of regulatory T-cells leads to moderate B-cell antigenicity in respiratory syncytial virus infection

Shao HY 1 , Huang JY 2 , Lin YW 2 , Yu SL 2 , Chitra E 3 , Chang CK 4 Show all authors , Sung WC 2 , Chong P 5 , Chow YH 6

Affiliations 

  • 1 Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Room No. R1-7033, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan; Graduate Program of Biotechnology in Medicine, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
  • 2 Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Room No. R1-7033, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan
  • 3 School of Medical Sciences, Division of Human Biology, International Medical University, Kuala Lumpur, Malaysia
  • 4 Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Room No. R1-7033, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan; Graduate School of Life Science, National Defense Medical Center, Taipei, Taiwan
  • 5 Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Room No. R1-7033, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan; Graduate Institute of Immunology, China Medical University, Taichung, Taiwan
  • 6 Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Room No. R1-7033, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan; Graduate Institute of Immunology, China Medical University, Taichung, Taiwan. Electronic address: choeyenh@nhri.org.tw
Int J Infect Dis, 2015 Dec;41:56-64.
PMID: 26555647 DOI: 10.1016/j.ijid.2015.10.026

Abstract

The regulation of the immunopathology of respiratory syncytial virus (RSV) by regulatory T-cells (CD4(+)CD25(+)Foxp3(+); Tregs) is not understood.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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