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Seroprevalence of diphtheria toxoid IgG antibodies in the Malaysian population

Yusoff AF 1 , Mohd Sharani ZZ 2 , Kee CC 3 , Md Iderus NH 2 , Md Zamri ASS 2 , Nagalingam T 4 Show all authors , Mohamad Bashaabidin MS 2 , Wan Ibadullah WAH 2 , Ghazali SM 2 , Yusof AY 5 , Ching YM 5 , Mohamed Nor N 5 , Kamarudin B 5 , Ahmad N 6 , Arip M 5

Affiliations 

  • 1 SEAMEO TROPMED Malaysia, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, 40170, Shah Alam, Selangor, Malaysia. ahmadfaudzi.y@moh.gov.my
  • 2 Biomedical Epidemiology Unit, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, 40170, Shah Alam, Selangor, Malaysia
  • 3 Sector for Biostatistics and Data Repository, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, 40170, Shah Alam, Selangor, Malaysia
  • 4 Infection Control Unit, Kuala Lumpur Hospital, Ministry of Health Malaysia, Jalan Pahang, 50588, Kuala Lumpur, Malaysia
  • 5 Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, 40170, Shah Alam, Selangor, Malaysia
  • 6 Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, 40170, Shah Alam, Selangor, Malaysia
BMC Infect Dis, 2021 Jun 16;21(1):581.
PMID: 34134646 DOI: 10.1186/s12879-021-06285-3

Abstract

BACKGROUND: Despite high childhood immunization coverage, sporadic cases of diphtheria have been reported in Malaysia in recent years. This study aims to evaluate the seroprevalence of diphtheria among the Malaysian population.

METHODS: A total of 3317 respondents age 2 years old to 60 years old were recruited in this study from August to November 2017. Enzyme-linked immunosorbent assay (ELISA) was used to measure the level of IgG antibody against the toxoid of C. diphtheriae in the blood samples of respondents. We classified respondent antibody levels based on WHO definition, as protective (≥0.1 IU/mL) and susceptible (

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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