Prevalence and risk factors of antibodies towards HLA Class I and Class II in Malaysian renal transplant candidates

Khairul-Fahmy N 1 , Ismail J 2 , Koay BT 2 , Md-Zakariah MZ 2 , Mansor S 2 , Zulkifli N 2 Show all authors , Mat-Ali SF 2 , Mohamed R 2 , Mustafa N 2 , Arip M 3

Affiliations 

  • 1 Transplantation Immunology Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia. norfarhana.kf@moh.gov.my
  • 2 Transplantation Immunology Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia
  • 3 Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia
BMC Nephrol, 2023 Feb 24;24(1):42.
PMID: 36829106 DOI: 10.1186/s12882-023-03085-6

Abstract

Antibody-mediated rejection (AMR) still persists as the major hurdle towards successful renal allograft survival. This paper aims to report on the HLA antibody landscape of renal transplant candidates in Malaysia. A total of 2,219 adult samples from 2016 to 2019 were analysed for anti-HLA antibodies using solid-phase assay. Our findings highlight the prevalence and risk factors for antibodies against HLA antigens in renal transplant settings, which could be beneficial for selecting compatible recipients from deceased organ donors. To the best of our knowledge, this study is the first to demonstrate that ethnic Malay and Chinese showed significantly higher prevalence of anti-HLA antibodies. Based on our multivariate analysis: (i) female gender was associated with higher risk for panel reactive antibodies (PRAs) against Class I, Class II, and Class I and II (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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