Genetic variants associated with phenytoin-related severe cutaneous adverse reactions

Chung WH 1 , Chang WC 2 , Lee YS 3 , Wu YY 2 , Yang CH 4 , Ho HC 5 Show all authors , Chen MJ 4 , Lin JY 5 , Hui RC 4 , Ho JC 6 , Wu WM 6 , Chen TJ 7 , Wu T 8 , Wu YR 8 , Hsih MS 8 , Tu PH 9 , Chang CN 9 , Hsu CN 10 , Wu TL 11 , Choon SE 12 , Hsu CK 13 , Chen DY 14 , Liu CS 15 , Lin CY 16 , Kaniwa N 17 , Saito Y 17 , Takahashi Y 18 , Nakamura R 17 , Azukizawa H 19 , Shi Y 20 , Wang TH 21 , Chuang SS 22 , Tsai SF 23 , Chang CJ 24 , Chang YS 25 , Hung SI 2 , Taiwan Severe Cutaneous Adverse Reaction Consortium , Japan Pharmacogenomics Data Science Consortium

Affiliations 

  • 1 Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan2Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan3College of Medicine, Chang Gung University, Taoyuan, Taiwa
  • 2 Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • 3 Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan
  • 4 Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan3College of Medicine, Chang Gung University, Taoyuan, Taiwan
  • 5 Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan3College of Medicine, Chang Gung University, Taoyuan, Taiwan
  • 6 College of Medicine, Chang Gung University, Taoyuan, Taiwan6Department of Dermatology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
  • 7 Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan7Department of Dermatology, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan
  • 8 College of Medicine, Chang Gung University, Taoyuan, Taiwan8Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan
  • 9 College of Medicine, Chang Gung University, Taoyuan, Taiwan9Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou, Taiwan
  • 10 College of Medicine, Chang Gung University, Taoyuan, Taiwan10Department of Pharmacy, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
  • 11 College of Medicine, Chang Gung University, Taoyuan, Taiwan11Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan
  • 12 Department of Dermatology, Hospital Sultanah Aminah Johor Bahru, Johor, Malaysia
  • 13 Department of Dermatology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan
  • 14 Department of Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan
  • 15 Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan
  • 16 Department of Pediatrics, China Medicine University, Taichung, Taiwan
  • 17 Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
  • 18 Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
  • 19 Department of Dermatology, Course of Integrated Medicine, Osaka University Graduate School of Medicine, Suita, Japan
  • 20 Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China
  • 21 College of Medicine, Chang Gung University, Taoyuan, Taiwan21Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou, Taiwan22Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan
  • 22 College of Medicine, Chang Gung University, Taoyuan, Taiwan23Department of Plastic Surgery and Burn Center, Chang Gung Memorial Hospital, Linkou, Taiwan
  • 23 Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan
  • 24 College of Medicine, Chang Gung University, Taoyuan, Taiwan25Biostatistical Center for Clinical Research, Chang Gung Memorial Hospital, Linkou, Taiwan
  • 25 Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
JAMA, 2014 Aug 6;312(5):525-34.
PMID: 25096692 DOI: 10.1001/jama.2014.7859

Abstract

The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basis of phenytoin-related severe cutaneous adverse reactions remains unknown.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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