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Genetic variation of pfhrp2 in Plasmodium falciparum isolates from Yemen and the performance of HRP2-based malaria rapid diagnostic test

Atroosh WM 1 , Al-Mekhlafi HM 2 , Al-Jasari A 3 , Sady H 4 , Al-Delaimy AK 5 , Nasr NA 6 Show all authors , Dawaki S 7 , Abdulsalam AM 8 , Ithoi I 9 , Lau YL 10 , Fong MY 11 , Surin J 12

Affiliations 

  • 1 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. wahib_atrosh@yahoo.com
  • 2 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. halmekhlafi@yahoo.com
  • 3 National Malaria Control programme, Ministry of Public Health and Population, Sana'a, Yemen. badryaman@yahoo.com
  • 4 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. hanysady@yahoo.com
  • 5 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. ahmed_soofi@yahoo.com
  • 6 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. nabilnesr@yahoo.com
  • 7 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. saldawaki@gmail.com
  • 8 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. fafo_1979@yahoo.com
  • 9 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. init@um.edu.my
  • 10 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. lauyeeling@um.edu.my
  • 11 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. fongmy@um.edu.my
  • 12 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. joharisurin@um.edu.my
Parasit Vectors, 2015;8:388.
PMID: 26198252 DOI: 10.1186/s13071-015-1008-x

Abstract

The genetic variation in the Plasmodium falciparum histidine-rich protein 2 (pfhrp2) gene that may compromise the use of pfhrp2-based rapid diagnostic tests (RDTs) for the diagnosis of malaria was assessed in P. falciparum isolates from Yemen.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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