Affiliations 

  • 1 Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala LumpurMalaysia; Novel Bacteria and Drug Discovery Research Group, School of Pharmacy, Monash University Malaysia, Selangor Darul EhsanMalaysia
  • 2 Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur Malaysia
  • 3 Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor Darul Ehsan Malaysia
  • 4 Novel Bacteria and Drug Discovery Research Group, School of Pharmacy, Monash University Malaysia, Selangor Darul EhsanMalaysia; Center of Health Outcomes Research and Therapeutic Safety, School of Pharmaceutical Sciences, University of Phayao, PhayaoThailand; Pharmaceutical Outcomes Research Center, Faculty of Pharmaceutical Sciences, Naresuan University, PhitsanulokThailand
  • 5 Center of Health Outcomes Research and Therapeutic Safety, School of Pharmaceutical Sciences, University of Phayao, PhayaoThailand; Division of Physiology, School of Medical Sciences, University of Phayao, PhayaoThailand
  • 6 Novel Bacteria and Drug Discovery Research Group, School of Pharmacy, Monash University Malaysia, Selangor Darul EhsanMalaysia; Center of Health Outcomes Research and Therapeutic Safety, School of Pharmaceutical Sciences, University of Phayao, PhayaoThailand
  • 7 UKM Medical Molecular Biology Institute, UKM Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur Malaysia
Front Microbiol, 2016;7:1114.
PMID: 27486446 DOI: 10.3389/fmicb.2016.01114

Abstract

Bacterial infections from various organisms including Vibrio sp. pose a serious hazard to humans in many forms from clinical infection to affecting the yield of agriculture and aquaculture via infection of livestock. Vibrio sp. is one of the main foodborne pathogens causing human infection and is also a common cause of losses in the aquaculture industry. Prophylactic and therapeutic usage of antibiotics has become the mainstay of managing this problem, however, this in turn led to the emergence of multidrug resistant strains of bacteria in the environment; which has raised awareness of the critical need for alternative non-antibiotic based methods of preventing and treating bacterial infections. Bacteriophages - viruses that infect and result in the death of bacteria - are currently of great interest as a highly viable alternative to antibiotics. This article provides an insight into bacteriophage application in controlling Vibrio species as well underlining the advantages and drawbacks of phage therapy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.