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Differential p16/INK4A cyclin-dependent kinase inhibitor expression correlates with chemotherapy efficacy in a cohort of 88 malignant pleural mesothelioma patients

Jennings CJ 1 , Murer B 2 , O'Grady A 3 , Hearn LM 1 , Harvey BJ 1 , Kay EW 3 Show all authors , Thomas W 4

Affiliations 

  • 1 Molecular Medicine Laboratories, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
  • 2 Department of Anatomy and Histopathology, Dell' Angelo Hospital, Via Paccagnella 11, Mestre, 30174 VE, Italy
  • 3 Department of Histopathology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
  • 4 1] Molecular Medicine Laboratories, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland [2] Perdana University - Royal College of Surgeons in Ireland School of Medicine, Jalan MAEPS Perdana, 43400 Serdang, Selangor, Malaysia
Br. J. Cancer, 2015 Jun 30;113(1):69-75.
PMID: 26057448 DOI: 10.1038/bjc.2015.187

Abstract

Malignant pleural mesothelioma (MPM) is a rare and essentially incurable malignancy most often linked with occupational exposure to asbestos fibres. In common with other malignancies, the development and progression of MPM is associated with extensive dysregulation of cell cycle checkpoint proteins that modulate cell proliferation, apoptosis, DNA repair and senescence.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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