Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells

Phan CW 1 , Sabaratnam V 1 , Bovicelli P 2 , Righi G 2 , Saso L 3

Affiliations 

  • 1 Mushroom Research Centre, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia
  • 2 C.N.R. IBPM, Department of Chemistry, Sapienza University of Rome, Rome, Italy
  • 3 Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy
Biofactors, 2016 Nov 12;42(6):591-599.
PMID: 27193378 DOI: 10.1002/biof.1296

Abstract

Negletein has been shown to have therapeutic potential for inflammation-associated diseases, but its effect on neurite outgrowth is still unknown. The present study showed that negletein alone did not trigger PC12 cells to differentiate and extend neurites. When compared with the cells in the untreated control, a significant (P 

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