The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells

Phan CW 1 , Sabaratnam V 2 , Yong WK 3 , Abd Malek SN 2

Affiliations 

  • 1 a Faculty of Medicine, Department of Anatomy , University of Malaya , Kuala Lumpur , Malaysia
  • 2 b Faculty of Science, Mushroom Research Centre, Institute of Biological Sciences , University of Malaya , Kuala Lumpur , Malaysia
  • 3 c Faculty of Science , Institute of Biological Sciences, University of Malaya , Kuala Lumpur , Malaysia
Nat Prod Res, 2018 May;32(10):1229-1233.
PMID: 28539058 DOI: 10.1080/14786419.2017.1331226

Abstract

Chalcones are a group of compounds widely distributed in plant kingdom. The aim of this study was to assess the neurite outgrowth stimulatory activity of selected chalcones, namely helichrysetin, xanthohumol and flavokawin-C. Using adherent rat pheochromocytoma (PC12 Adh) cells, the chalcones were subjected to neurite outgrowth assay and the extracellular nerve growth factor (NGF) levels were determined. Xanthohumol (10 μg/mL) displayed the highest (p 

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